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ZNF610 zinc finger protein 610 [ Homo sapiens (human) ]

Gene ID: 162963, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF610provided by HGNC
Official Full Name
zinc finger protein 610provided by HGNC
Primary source
HGNC:HGNC:26687
See related
Ensembl:ENSG00000167554 AllianceGenome:HGNC:26687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 6.2), ovary (RPKM 3.3) and 20 other tissues See more
Orthologs
all
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Genomic context

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See ZNF610 in Genome Data Viewer
Location:
19q13.41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52330221..52367778)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55416488..55455012)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52839496..52871031)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 766 Neighboring gene microRNA 643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15045 Neighboring gene zinc finger protein 480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52841280-52841780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15048 Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52900414-52901613 Neighboring gene zinc finger protein 528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma. Shi Y, et al. Cell Biochem Funct, 2024 Jun. PMID 38898665
  2. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article
  3. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma.
    Title: Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36040, MGC102679, DKFZp547A1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 610
Names
zink finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161425.2 → NP_001154897.1  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_001154897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, AK290888, BC039903, DA133752, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
    Related
    ENSP00000383922.2, ENST00000403906.8
    Conserved Domains (6) summary
    smart00349
    Location:24 → 82
    KRAB; krueppel associated box
    COG5048
    Location:257 → 446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:274 → 297
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001161426.2 → NP_001154898.1  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_001154898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, BC105967, DA133752, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
    Related
    ENSP00000324441.8, ENST00000321287.12
    Conserved Domains (6) summary
    smart00349
    Location:24 → 82
    KRAB; krueppel associated box
    COG5048
    Location:257 → 446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:274 → 297
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001161427.2 → NP_001154899.1  zinc finger protein 610 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. Isoform b is shorter than isoform a.
    Source sequence(s)
    AC010320, AK093359, BC039903, BC105967, DA133752, DB577508
    Consensus CDS
    CCDS54309.1
    UniProtKB/Swiss-Prot
    Q8N9Z0
    Related
    ENSP00000471021.1, ENST00000601151.5
    Conserved Domains (6) summary
    smart00349
    Location:24 → 64
    KRAB; krueppel associated box
    COG5048
    Location:214 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217 → 239
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:231 → 254
    zf-H2C2_2; Zinc-finger double domain

  4. NM_173530.3 → NP_775801.2  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_775801.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, AK093359, BC105967, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
    Related
    ENSP00000327597.7, ENST00000327920.12
    Conserved Domains (6) summary
    smart00349
    Location:24 → 82
    KRAB; krueppel associated box
    COG5048
    Location:257 → 446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260 → 282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:274 → 297
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52330221..52367778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438286.1 → XP_047294242.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

  2. XM_047438287.1 → XP_047294243.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
    Related
    ENSP00000485001.1, ENST00000616431.2

  3. XM_047438285.1 → XP_047294241.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

  4. XM_047438284.1 → XP_047294240.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55416488..55455012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320025.1 → XP_054176000.1  zinc finger protein 610 isoform X1

  2. XM_054320026.1 → XP_054176001.1  zinc finger protein 610 isoform X1

  3. XM_054320024.1 → XP_054175999.1  zinc finger protein 610 isoform X1

  4. XM_054320023.1 → XP_054175998.1  zinc finger protein 610 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9Z0.2 GenPept UniProtKB/Swiss-Prot:Q8N9Z0

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