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ZNF610 zinc finger protein 610 [ Homo sapiens (human) ]

Gene ID: 162963, updated on 5-Aug-2022

Summary

Official Symbol
ZNF610provided by HGNC
Official Full Name
zinc finger protein 610provided by HGNC
Primary source
HGNC:HGNC:26687
See related
Ensembl:ENSG00000167554 AllianceGenome:HGNC:26687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.2), ovary (RPKM 3.3) and 20 other tissues See more
Orthologs
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Genomic context

See ZNF610 in Genome Data Viewer
Location:
19q13.41
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52330221..52367778)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55423471..55455012)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52839496..52871031)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 766 Neighboring gene microRNA 643 Neighboring gene zinc finger protein 480 Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene zinc finger protein 528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36040, MGC102679, DKFZp547A1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 610
Names
zink finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161425.2NP_001154897.1  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_001154897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, AK290888, BC039903, DA133752, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    Q8N9Z0, Q8NDS9
    Related
    ENSP00000383922.2, ENST00000403906.8
    Conserved Domains (6) summary
    smart00349
    Location:2482
    KRAB; krueppel associated box
    COG5048
    Location:257446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:274297
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001161426.2NP_001154898.1  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_001154898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, BC105967, DA133752, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    Q8N9Z0, Q8NDS9
    Related
    ENSP00000324441.8, ENST00000321287.12
    Conserved Domains (6) summary
    smart00349
    Location:2482
    KRAB; krueppel associated box
    COG5048
    Location:257446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:274297
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001161427.2NP_001154899.1  zinc finger protein 610 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. Isoform b is shorter than isoform a.
    Source sequence(s)
    AC010320, AK093359, BC039903, BC105967, DA133752, DB577508
    Consensus CDS
    CCDS54309.1
    UniProtKB/Swiss-Prot
    Q8N9Z0
    Related
    ENSP00000471021.1, ENST00000601151.5
    Conserved Domains (6) summary
    smart00349
    Location:2464
    KRAB; krueppel associated box
    COG5048
    Location:214403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217239
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:231254
    zf-H2C2_2; Zinc-finger double domain
  4. NM_173530.3NP_775801.2  zinc finger protein 610 isoform a

    See identical proteins and their annotated locations for NP_775801.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC010320, AK093359, BC105967, DB577508
    Consensus CDS
    CCDS12851.1
    UniProtKB/Swiss-Prot
    Q8N9Z0, Q8NDS9
    Related
    ENSP00000327597.7, ENST00000327920.12
    Conserved Domains (6) summary
    smart00349
    Location:2482
    KRAB; krueppel associated box
    COG5048
    Location:257446
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260282
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:274297
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52330221..52367778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438286.1XP_047294242.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    Q8NDS9
  2. XM_047438287.1XP_047294243.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    Q8NDS9
    Related
    ENSP00000485001.1, ENST00000616431.2
  3. XM_047438285.1XP_047294241.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    Q8NDS9
  4. XM_047438284.1XP_047294240.1  zinc finger protein 610 isoform X1

    UniProtKB/Swiss-Prot
    Q8NDS9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55423471..55455012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)