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ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]

Gene ID: 155061, updated on 4-Nov-2022

Summary

Official Symbol
ZNF746provided by HGNC
Official Full Name
zinc finger protein 746provided by HGNC
Primary source
HGNC:HGNC:21948
See related
Ensembl:ENSG00000181220 MIM:613914; AllianceGenome:HGNC:21948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARIS
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF746 in Genome Data Viewer
Location:
7q36.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149472696..149497809, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150654556..150679673, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149169787..149194900, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene zinc finger protein 777 Neighboring gene tRNA-Cys (anticodon GCA) 16-1 Neighboring gene tRNA-Cys (anticodon GCA) 22-1 Neighboring gene zinc finger family member 767, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31413

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 746
Names
parkin-interacting substrate
parkin-interacting sustrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163474.2NP_001156946.1  zinc finger protein 746 isoform 1

    See identical proteins and their annotated locations for NP_001156946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004932, AI991498, AK291814, BC068505
    Consensus CDS
    CCDS55180.1
    UniProtKB/Swiss-Prot
    Q6NUN9
    Related
    ENSP00000508891.1, ENST00000685153.1
    Conserved Domains (6) summary
    cd07765
    Location:106135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106156
    KRAB; krueppel associated box
    COG5048
    Location:512589
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:513533
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:567589
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:525549
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001363517.2NP_001350446.1  zinc finger protein 746 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004932, AC073314
    Consensus CDS
    CCDS87562.1
    UniProtKB/TrEMBL
    A0A2R8YDQ5
    Related
    ENSP00000493970.1, ENST00000644635.1
    Conserved Domains (4) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:526603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001394198.1NP_001381127.1  zinc finger protein 746 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004932, AC073314
    Consensus CDS
    CCDS94227.1
    UniProtKB/TrEMBL
    A0A8J9FQ52
    Related
    ENSP00000395007.3, ENST00000458143.7
    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    sd00017
    Location:528548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:582604
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
    pfam16622
    Location:522548
    zf-C2H2_11; zinc-finger C2H2-type
  4. NM_152557.5NP_689770.3  zinc finger protein 746 isoform 2

    See identical proteins and their annotated locations for NP_689770.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one residue near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004932, AC073314, AI991498, BC068505, BM512385
    Consensus CDS
    CCDS5897.1
    UniProtKB/Swiss-Prot
    Q6NUN9, Q6ZRF9
    Related
    ENSP00000345140.3, ENST00000340622.8
    Conserved Domains (6) summary
    cd07765
    Location:106135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106156
    KRAB; krueppel associated box
    COG5048
    Location:511588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:512532
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:566588
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524548
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149472696..149497809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419925.1XP_047275881.1  zinc finger protein 746 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150654556..150679673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)