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ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]

Gene ID: 155061, updated on 24-Nov-2020

Summary

Official Symbol
ZNF746provided by HGNC
Official Full Name
zinc finger protein 746provided by HGNC
Primary source
HGNC:HGNC:21948
See related
Ensembl:ENSG00000181220 MIM:613914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARIS
Expression
Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF746 in Genome Data Viewer
Location:
7q36.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (149472696..149497832, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149169884..149194928, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene zinc finger protein 777 Neighboring gene tRNA-Cys (anticodon GCA) 16-1 Neighboring gene tRNA-Cys (anticodon GCA) 22-1 Neighboring gene zinc finger family member 767, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31413

Gene Ontology Provided by GOA

Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 746
Names
parkin-interacting substrate
parkin-interacting sustrate

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163474.2NP_001156946.1  zinc finger protein 746 isoform 1

    See identical proteins and their annotated locations for NP_001156946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004932, AI991498, AK291814, BC068505
    Consensus CDS
    CCDS55180.1
    UniProtKB/Swiss-Prot
    Q6NUN9
    Related
    ENSP00000395007.2, ENST00000458143.6
    Conserved Domains (6) summary
    cd07765
    Location:106135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106156
    KRAB; krueppel associated box
    COG5048
    Location:512589
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:513533
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:567589
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:525549
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001363517.2NP_001350446.1  zinc finger protein 746 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004932, AC073314
    Consensus CDS
    CCDS87562.1
    Related
    ENSP00000493970.1, ENST00000644635.1
    Conserved Domains (4) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:526603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_152557.5NP_689770.3  zinc finger protein 746 isoform 2

    See identical proteins and their annotated locations for NP_689770.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one residue near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004932, AC073314, AI991498, BC068505, BM512385
    Consensus CDS
    CCDS5897.1
    UniProtKB/Swiss-Prot
    Q6NUN9
    Related
    ENSP00000345140.3, ENST00000340622.8
    Conserved Domains (6) summary
    cd07765
    Location:106135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:106156
    KRAB; krueppel associated box
    COG5048
    Location:511588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:512532
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:566588
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524548
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    149472696..149497832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249955.2XP_005250012.1  zinc finger protein 746 isoform X1

    See identical proteins and their annotated locations for XP_005250012.1

    Conserved Domains (6) summary
    cd07765
    Location:111150
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:527604
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:528548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:582604
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:540564
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011515838.1XP_011514140.1  zinc finger protein 746 isoform X4

    Conserved Domains (6) summary
    cd07765
    Location:93122
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:93143
    KRAB; krueppel associated box
    COG5048
    Location:499576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:554576
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:512536
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005249957.1XP_005250014.1  zinc finger protein 746 isoform X3

    Conserved Domains (6) summary
    cd07765
    Location:98137
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:98158
    KRAB; krueppel associated box
    COG5048
    Location:514591
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:569591
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:527551
    zf-H2C2_2; Zinc-finger double domain
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