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Zfp746 zinc finger protein 746 [ Mus musculus (house mouse) ]

Gene ID: 69228, updated on 17-Aug-2024

Summary

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Official Symbol
Zfp746provided by MGI
Official Full Name
zinc finger protein 746provided by MGI
Primary source
MGI:MGI:1916478
See related
Ensembl:ENSMUSG00000057691 AllianceGenome:MGI:1916478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf746; 2810407L07Rik
Summary
Enables ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron death. Predicted to be located in cytosol and nucleoplasm. Is expressed in bladder; left lung epithelium; right lung epithelium; testis; and ureter. Orthologous to human ZNF746 (zinc finger protein 746). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 14.4), thymus adult (RPKM 13.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.04 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48039325..48064275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48062391..48086986, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15786 Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene STARR-seq mESC enhancer starr_15788 Neighboring gene zinc finger protein 777 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 10 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. Kim H, et al. Biochem Biophys Res Commun, 2021 Jul 23. PMID 34062393
  2. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Jo A, et al. Sci Transl Med, 2021 Jul 28. PMID 34321320, Free PMC Article
  3. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brahmachari S, et al. Brain, 2019 Aug 1. PMID 31237944, Free PMC Article
  4. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Stevens DA, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324925, Free PMC Article
  5. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. Panicker N, et al. Neuron, 2022 Aug 3. PMID 35654037, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
    Title: Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
  2. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
    Title: PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
  3. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
    Title: ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
  4. PARIS overexpression leads to reduced mitochondrial number and structural abnormalities
    Title: Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
  5. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine neurons in a PARIS-dependent manner.
    Title: PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 746

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163475.1 → NP_001156947.1  zinc finger protein 746 isoform 1

    See identical proteins and their annotated locations for NP_001156947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS51762.1
    UniProtKB/Swiss-Prot
    E9QPR1, Q3U133
    Related
    ENSMUSP00000072868.7, ENSMUST00000073124.9
    Conserved Domains (6) summary
    cd07765
    Location:108 → 135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:518 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:573 → 595
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:531 → 555
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001347142.1 → NP_001334071.1  zinc finger protein 746 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS85036.1
    UniProtKB/TrEMBL
    A0A0N4SWG2
    Related
    ENSMUSP00000145506.2, ENSMUST00000203609.3

  3. NM_001362062.1 → NP_001348991.1  zinc finger protein 746 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC166290
    Conserved Domains (4) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:490 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491 → 511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:545 → 567
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48039325..48064275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152290.1 → XP_036008183.1  zinc finger protein 746 isoform X12

    Conserved Domains (6) summary
    COG5048
    Location:479 → 557
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:534 → 556
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:521 → 545
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:107 → 157
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. XM_036152289.1 → XP_036008182.1  zinc finger protein 746 isoform X11

    Conserved Domains (6) summary
    COG5048
    Location:480 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:481 → 501
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:535 → 557
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:522 → 546
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:107 → 157
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_036152291.1 → XP_036008184.1  zinc finger protein 746 isoform X14

    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:475 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:476 → 496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:530 → 552
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:517 → 541
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030255585.2 → XP_030111445.1  zinc finger protein 746 isoform X13

    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:476 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:477 → 497
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:531 → 553
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:518 → 542
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006506559.5 → XP_006506622.1  zinc finger protein 746 isoform X6

    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:524 → 602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525 → 545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579 → 601
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:566 → 590
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011241457.4 → XP_011239759.1  zinc finger protein 746 isoform X9

    Conserved Domains (6) summary
    COG5048
    Location:495 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:550 → 572
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:110 → 151
    KRAB; KRAB box
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:537 → 561
    zf-H2C2_2; Zinc-finger double domain

  7. XM_017321730.3 → XP_017177219.1  zinc finger protein 746 isoform X10

    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:491 → 569
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:492 → 512
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:546 → 568
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:533 → 557
    zf-H2C2_2; Zinc-finger double domain

  8. XM_030255584.2 → XP_030111444.1  zinc finger protein 746 isoform X4

    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:532 → 610
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:533 → 553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:587 → 609
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:574 → 598
    zf-H2C2_2; Zinc-finger double domain

  9. XM_006506557.5 → XP_006506620.1  zinc finger protein 746 isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:533 → 611
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:534 → 554
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:588 → 610
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:575 → 599
    zf-H2C2_2; Zinc-finger double domain

  10. XM_011241456.4 → XP_011239758.1  zinc finger protein 746 isoform X8

    Conserved Domains (5) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:551 → 573
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:538 → 562
    zf-H2C2_2; Zinc-finger double domain

  11. XM_011241455.4 → XP_011239757.1  zinc finger protein 746 isoform X7

    Conserved Domains (5) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:552 → 574
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:539 → 563
    zf-H2C2_2; Zinc-finger double domain

  12. XM_011241454.4 → XP_011239756.1  zinc finger protein 746 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:538 → 616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:539 → 559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593 → 615
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:580 → 604
    zf-H2C2_2; Zinc-finger double domain

  13. XM_006506556.5 → XP_006506619.1  zinc finger protein 746 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:111 → 171
    KRAB; krueppel associated box
    COG5048
    Location:539 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:594 → 616
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:581 → 605
    zf-H2C2_2; Zinc-finger double domain

  14. XM_036152288.1 → XP_036008181.1  zinc finger protein 746 isoform X5

    Conserved Domains (6) summary
    smart00349
    Location:98 → 158
    KRAB; krueppel associated box
    COG5048
    Location:526 → 604
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527 → 547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581 → 603
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:12 → 68
    DUF3669; Zinc finger protein
    pfam13465
    Location:568 → 592
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U133.3 GenPept UniProtKB/Swiss-Prot:Q3U133

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