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Zfp746 zinc finger protein 746 [ Mus musculus (house mouse) ]

Gene ID: 69228, updated on 7-Feb-2023

Summary

Official Symbol
Zfp746provided by MGI
Official Full Name
zinc finger protein 746provided by MGI
Primary source
MGI:MGI:1916478
See related
Ensembl:ENSMUSG00000057691 AllianceGenome:MGI:1916478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf746; 2810407L07Rik
Summary
Enables ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron death. Predicted to be located in cytosol and nucleoplasm. Is expressed in bladder; left lung epithelium; right lung epithelium; testis; and ureter. Orthologous to human ZNF746 (zinc finger protein 746). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 14.4), thymus adult (RPKM 13.9) and 28 other tissues See more
Orthologs
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Genomic context

See Zfp746 in Genome Data Viewer
Location:
6; 6 B2.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48039325..48064275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48062391..48086986, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene zinc finger protein 777 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 10 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163475.1NP_001156947.1  zinc finger protein 746 isoform 1

    See identical proteins and their annotated locations for NP_001156947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS51762.1
    UniProtKB/Swiss-Prot
    E9QPR1, Q3U133
    Related
    ENSMUSP00000072868.7, ENSMUST00000073124.9
    Conserved Domains (6) summary
    cd07765
    Location:108135
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:107156
    KRAB; krueppel associated box
    COG5048
    Location:518596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:573595
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:531555
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001347142.1NP_001334071.1  zinc finger protein 746 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC166290
    Consensus CDS
    CCDS85036.1
    UniProtKB/TrEMBL
    A0A0N4SWG2
    Related
    ENSMUSP00000145506.2, ENSMUST00000203609.3
  3. NM_001362062.1NP_001348991.1  zinc finger protein 746 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC166290
    Conserved Domains (4) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:490568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:545567
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48039325..48064275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152290.1XP_036008183.1  zinc finger protein 746 isoform X12

    Conserved Domains (6) summary
    COG5048
    Location:479557
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:480500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:534556
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:521545
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:107157
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. XM_036152289.1XP_036008182.1  zinc finger protein 746 isoform X11

    Conserved Domains (6) summary
    COG5048
    Location:480558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:481501
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:535557
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:522546
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:107157
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. XM_036152291.1XP_036008184.1  zinc finger protein 746 isoform X14

    Conserved Domains (6) summary
    smart00349
    Location:107156
    KRAB; krueppel associated box
    COG5048
    Location:475553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:476496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:530552
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:517541
    zf-H2C2_2; Zinc-finger double domain
  4. XM_030255585.2XP_030111445.1  zinc finger protein 746 isoform X13

    Conserved Domains (6) summary
    smart00349
    Location:107156
    KRAB; krueppel associated box
    COG5048
    Location:476554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:477497
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:531553
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:518542
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006506559.5XP_006506622.1  zinc finger protein 746 isoform X6

    Conserved Domains (6) summary
    smart00349
    Location:107156
    KRAB; krueppel associated box
    COG5048
    Location:524602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579601
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:566590
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011241457.4XP_011239759.1  zinc finger protein 746 isoform X9

    Conserved Domains (6) summary
    COG5048
    Location:495573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:550572
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:110151
    KRAB; KRAB box
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:537561
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017321730.3XP_017177219.1  zinc finger protein 746 isoform X10

    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:491569
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:492512
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:546568
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:533557
    zf-H2C2_2; Zinc-finger double domain
  8. XM_030255584.2XP_030111444.1  zinc finger protein 746 isoform X4

    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:532610
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:533553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:587609
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:574598
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006506557.5XP_006506620.1  zinc finger protein 746 isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:533611
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:534554
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:588610
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:575599
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011241456.4XP_011239758.1  zinc finger protein 746 isoform X8

    Conserved Domains (5) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    sd00017
    Location:497517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:551573
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:538562
    zf-H2C2_2; Zinc-finger double domain
  11. XM_011241455.4XP_011239757.1  zinc finger protein 746 isoform X7

    Conserved Domains (5) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    sd00017
    Location:498518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:552574
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:539563
    zf-H2C2_2; Zinc-finger double domain
  12. XM_011241454.4XP_011239756.1  zinc finger protein 746 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:538616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:539559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:580604
    zf-H2C2_2; Zinc-finger double domain
  13. XM_006506556.5XP_006506619.1  zinc finger protein 746 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:111171
    KRAB; krueppel associated box
    COG5048
    Location:539617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:540560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:594616
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:2581
    DUF3669; Zinc finger protein
    pfam13465
    Location:581605
    zf-H2C2_2; Zinc-finger double domain
  14. XM_036152288.1XP_036008181.1  zinc finger protein 746 isoform X5

    Conserved Domains (6) summary
    smart00349
    Location:98158
    KRAB; krueppel associated box
    COG5048
    Location:526604
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527547
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581603
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:1268
    DUF3669; Zinc finger protein
    pfam13465
    Location:568592
    zf-H2C2_2; Zinc-finger double domain