Format

Send to:

Choose Destination

CXADR CXADR Ig-like cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 1525, updated on 8-Jul-2021

Summary

Official Symbol
CXADRprovided by HGNC
Official Full Name
CXADR Ig-like cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:2559
See related
Ensembl:ENSG00000154639 MIM:602621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAR; HCAR; CAR4/6
Summary
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CXADR in Genome Data Viewer
Location:
21q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (17513016..17636213)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18885361..18965928)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 40 Neighboring gene RNA, 7SL, cytoplasmic 163, pseudogene Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene BTG anti-proliferation factor 3 Neighboring gene BTG3 antisense RNA 1 Neighboring gene uncharacterized LOC105372741 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene chromosome 21 open reading frame 91

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesive protein binding involved in AV node cell-bundle of His cell communication IC
Inferred by Curator
more info
PubMed 
enables connexin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in AV node cell to bundle of His cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in AV node cell-bundle of His cell adhesion involved in cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell junction organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-delta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in germ cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of AV node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transepithelial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coxsackievirus and adenovirus receptor
Names
46 kD coxsackievirus and adenovirus receptor (CAR) protein
CVB3-binding protein
HCVADR
coxsackie virus and adenovirus receptor
coxsackievirus B-adenovirus receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029458.1 RefSeqGene

    Range
    5001..85674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207063.2NP_001193992.1  coxsackievirus and adenovirus receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, alternatively referred to as beta or CAR4/7) lacks two consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AP000967, AY072912, CV570985
    Consensus CDS
    CCDS56205.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383030.1, ENST00000400166.5
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  2. NM_001207064.2NP_001193993.1  coxsackievirus and adenovirus receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001193993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, alternatively referred to as gamma or CAR3/7) lacks three consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AP000967, AY072911, CV570985
    Consensus CDS
    CCDS56206.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383029.1, ENST00000400165.5
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  3. NM_001207065.2NP_001193994.1  coxsackievirus and adenovirus receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001193994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, alternatively referred to as delta or CAR2/7) lacks four consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AP000967, AY072910, CV570985
    Consensus CDS
    CCDS56207.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000348620.6, ENST00000356275.10
  4. NM_001207066.2NP_001193995.1  coxsackievirus and adenovirus receptor isoform 5 precursor

    See identical proteins and their annotated locations for NP_001193995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, alternatively referred to as CAREx8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000967, CV570985
    Consensus CDS
    CCDS56204.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383033.1, ENST00000400169.1
    Conserved Domains (3) summary
    smart00410
    Location:155229
    IG_like; Immunoglobulin like
    cd00096
    Location:149153
    Ig; Ig strand A' [structural motif]
    cd20960
    Location:20136
    IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins
  5. NM_001338.5NP_001329.1  coxsackievirus and adenovirus receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, alternatively referred to as alpha or CAREx7) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK313526, AP000967
    Consensus CDS
    CCDS33519.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000284878.7, ENST00000284878.12
    Conserved Domains (2) summary
    smart00409
    Location:155229
    IG; Immunoglobulin
    cd20960
    Location:20136
    IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    17513016..17636213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529478.2XP_011527780.1  coxsackievirus and adenovirus receptor isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  2. XM_011529476.2XP_011527778.1  coxsackievirus and adenovirus receptor isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:155229
    IG_like; Immunoglobulin like
    cd00096
    Location:149153
    Ig; Ig strand A' [structural motif]
    cd20960
    Location:20136
    IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins
  3. XM_011529479.1XP_011527781.1  coxsackievirus and adenovirus receptor isoform X4

    See identical proteins and their annotated locations for XP_011527781.1

    UniProtKB/Swiss-Prot
    P78310
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  4. XM_011529477.2XP_011527779.1  coxsackievirus and adenovirus receptor isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain

RNA

  1. XR_001754814.1 RNA Sequence

Support Center