Format

Send to:

Choose Destination

CXADR CXADR, Ig-like cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 1525, updated on 9-Dec-2018

Summary

Official Symbol
CXADRprovided by HGNC
Official Full Name
CXADR, Ig-like cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:2559
See related
Ensembl:ENSG00000154639 MIM:602621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAR; HCAR; CAR4/6
Summary
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in skin (RPKM 12.7), duodenum (RPKM 7.3) and 23 other tissues See more
Orthologs

Genomic context

See CXADR in Genome Data Viewer
Location:
21q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (17512906..17636213)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18885224..18965897)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 40 Neighboring gene RNA, 7SL, cytoplasmic 163, pseudogene Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene BTG anti-proliferation factor 3 Neighboring gene BTG3 antisense RNA 1 Neighboring gene uncharacterized LOC105372741 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene chromosome 21 open reading frame 91

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell adhesive protein binding involved in AV node cell-bundle of His cell communication IC
Inferred by Curator
more info
PubMed 
connexin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
AV node cell to bundle of His cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
AV node cell-bundle of His cell adhesion involved in cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
cardiac muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction organization ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-delta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
germ cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of AV node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
transepithelial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
intercalated disc IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coxsackievirus and adenovirus receptor
Names
46 kD coxsackievirus and adenovirus receptor (CAR) protein
CVB3-binding protein
HCVADR
coxsackie virus and adenovirus receptor
coxsackievirus B-adenovirus receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029458.1 RefSeqGene

    Range
    5001..85674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207063.1NP_001193992.1  coxsackievirus and adenovirus receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, alternatively referred to as beta or CAR4/7) lacks two consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AI498294, AP000967, AY072912, CV570985
    Consensus CDS
    CCDS56205.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383030.1, ENST00000400166.5
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  2. NM_001207064.1NP_001193993.1  coxsackievirus and adenovirus receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001193993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, alternatively referred to as gamma or CAR3/7) lacks three consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AI498294, AP000967, AY072911, CV570985
    Consensus CDS
    CCDS56206.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383029.1, ENST00000400165.5
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  3. NM_001207065.1NP_001193994.1  coxsackievirus and adenovirus receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001193994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, alternatively referred to as delta or CAR2/7) lacks four consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AI498294, AP000967, AY072910, CV570985
    Consensus CDS
    CCDS56207.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000348620.6, ENST00000356275.10
  4. NM_001207066.1NP_001193995.1  coxsackievirus and adenovirus receptor isoform 5 precursor

    See identical proteins and their annotated locations for NP_001193995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, alternatively referred to as CAREx8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000967, CV570985
    Consensus CDS
    CCDS56204.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000383033.1, ENST00000400169.1
    Conserved Domains (2) summary
    smart00410
    Location:155229
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  5. NM_001338.5NP_001329.1  coxsackievirus and adenovirus receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, alternatively referred to as alpha or CAREx7) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK313526, AP000967
    Consensus CDS
    CCDS33519.1
    UniProtKB/Swiss-Prot
    P78310
    Related
    ENSP00000284878.7, ENST00000284878.11
    Conserved Domains (2) summary
    smart00410
    Location:155229
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    17512906..17636213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529478.2XP_011527780.1  coxsackievirus and adenovirus receptor isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  2. XM_011529476.2XP_011527778.1  coxsackievirus and adenovirus receptor isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:150216
    Ig_3; Immunoglobulin domain
  3. XM_011529479.1XP_011527781.1  coxsackievirus and adenovirus receptor isoform X4

    See identical proteins and their annotated locations for XP_011527781.1

    UniProtKB/Swiss-Prot
    P78310
    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain
  4. XM_011529477.2XP_011527779.1  coxsackievirus and adenovirus receptor isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:29137
    IG_like; Immunoglobulin like
    pfam07686
    Location:23138
    V-set; Immunoglobulin V-set domain

RNA

  1. XR_001754814.1 RNA Sequence

Support Center