Cxadr coxsackie virus and adenovirus receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxadrprovided by MGI
Official Full Name: coxsackie virus and adenovirus receptorprovided by MGI
Primary source: MGI:MGI:1201679
See related: Ensembl:ENSMUSG00000022865 AllianceGenome:MGI:1201679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAR; MCAR; MCVADR; 2610206D03Rik
Summary: This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression: Broad expression in CNS E18 (RPKM 24.6), whole brain E14.5 (RPKM 17.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16; 16 C3.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (78098114..78156673)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (78301226..78359785)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis.
Title: CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis.
Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
Title: Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
the Cxadr-Adam10 complex might moderate TJ integrity/stability and play pivotal roles during early embryonic development.
Title: The Cxadr-Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice.
In this study, a CEACAM-1 overexpression vector was constructed, and the effects of CC1 overexpression post CVB3 infection were analyzed. The results suggested that CC1 may promote CAR expression in cardiomyocytes after CVB3 infection, and CAR may be a potential target for CC1 to regulate the CVB3-induced process of myocardial injury. CC1 might regulate CAR expression by activating the CC1-SYK- TNF-[alpha] signaling axis.
Title: CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor.
In blastocysts, CAR was expressed at the cell contacts within the inner cell mass as well as in the trophectoderm (TE) where CAR was found together with ZO1 at the apical contacts, suggesting that CAR builds up apical TJs in TE and mediates cell adhesion in TE and inner cell mass. CAR was expressed in TE of implanting embryos as well as endometrial epithelium.
Title: Coxsackievirus and Adenovirus Receptor, a Tight Junction Protein, in Peri-Implantation Mouse Embryos.
Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction.
Title: Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.
Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response
Title: Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.
the intracellular domain of CAR differentially regulates AdV entry and trafficking. Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family.
Title: The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry.
Conclude that CXADR possesses no direct role in testicular physiology in vivo.
Title: Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier.
with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction.
Title: Down-regulation of coxsakie and adenovirus receptor during embryo implantation.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cxadr (e-PCR), detects polymorphism
- UniSTS:259598

Y11929 (e-PCR)
- UniSTS:160584

AW553441 (e-PCR)
- UniSTS:180935

NoName (e-PCR)
- UniSTS:237533

NoName (e-PCR)
- UniSTS:237534

Z72000 (e-PCR)
- UniSTS:125939

Cxadr (e-PCR), detects polymorphism
- UniSTS:259064

Homology

Homologs of the Cxadr gene: The Cxadr gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Cxadr
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesive protein binding involved in AV node cell-bundle of His cell communication	IC Inferred by Curator more info	PubMed
enables connexin binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AV node cell to bundle of His cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in AV node cell-bundle of His cell adhesion involved in cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in gamma-delta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in germ cell migration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in wound healing	IC Inferred by Curator more info	PubMed
involved_in regulation of AV node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coxsackievirus and adenovirus receptor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025192.3 → NP_001020363.1 coxsackievirus and adenovirus receptor homolog isoform a precursor

See identical proteins and their annotated locations for NP_001020363.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC130844, AK141274, AK145569

Consensus CDS

CCDS28276.1

UniProtKB/Swiss-Prot

P97792, Q9DBJ8

UniProtKB/TrEMBL

A0A8C6GYL3

Related

ENSMUSP00000023572.8, ENSMUST00000023572.15

Conserved Domains (3) summary

cd12087
Location:238 → 271

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:154 → 222

ig; Immunoglobulin domain

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain
NM_001276263.1 → NP_001263192.1 coxsackievirus and adenovirus receptor homolog isoform c precursor

See identical proteins and their annotated locations for NP_001263192.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a.

Source sequence(s)

AC130844

Consensus CDS

CCDS88952.1

UniProtKB/Swiss-Prot

P97792

Related

ENSMUSP00000156281.2, ENSMUST00000231356.2

Conserved Domains (2) summary

smart00410
Location:27 → 137

IG_like; Immunoglobulin like

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain
NM_009988.4 → NP_034118.1 coxsackievirus and adenovirus receptor homolog isoform b precursor

See identical proteins and their annotated locations for NP_034118.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.

Source sequence(s)

AC130844, Y11929

Consensus CDS

CCDS37379.1

UniProtKB/Swiss-Prot

P97792

UniProtKB/TrEMBL

A0A8C6H177

Related

ENSMUSP00000109867.3, ENSMUST00000114229.4

Conserved Domains (3) summary

cd12087
Location:238 → 271

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:154 → 222

ig; Immunoglobulin domain

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

78098114..78156673

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248956.1 → XP_030104816.1 coxsackievirus and adenovirus receptor homolog isoform X1

UniProtKB/Swiss-Prot

Q9DBJ8

UniProtKB/TrEMBL

A0A8C6GYL3

Conserved Domains (3) summary

cd12087
Location:238 → 271

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:154 → 222

ig; Immunoglobulin domain

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain
XM_006522884.5 → XP_006522947.1 coxsackievirus and adenovirus receptor homolog isoform X2

See identical proteins and their annotated locations for XP_006522947.1

UniProtKB/Swiss-Prot

P97792

UniProtKB/TrEMBL

A0A8C6H177

Conserved Domains (3) summary

cd12087
Location:238 → 271

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:154 → 222

ig; Immunoglobulin domain

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain
XM_006522883.5 → XP_006522946.1 coxsackievirus and adenovirus receptor homolog isoform X1

See identical proteins and their annotated locations for XP_006522946.1

UniProtKB/Swiss-Prot

P97792, Q9DBJ8

UniProtKB/TrEMBL

A0A8C6GYL3

Conserved Domains (3) summary

cd12087
Location:238 → 271

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:154 → 222

ig; Immunoglobulin domain

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain
XM_017316864.2 → XP_017172353.1 coxsackievirus and adenovirus receptor homolog isoform X3

Conserved Domains (2) summary

cd12087
Location:109 → 142

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00047
Location:25 → 93

ig; Immunoglobulin domain