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Hic1 hypermethylated in cancer 1 [ Mus musculus (house mouse) ]

Gene ID: 15248, updated on 18-Sep-2024

Summary

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Official Symbol
Hic1provided by MGI
Official Full Name
hypermethylated in cancer 1provided by MGI
Primary source
MGI:MGI:1338010
See related
Ensembl:ENSMUSG00000043099 AllianceGenome:MGI:1338010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIC-1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 27.9), limb E14.5 (RPKM 25.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Hic1 in Genome Data Viewer
Location:
11 B5; 11 45.76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75052203..75059970, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75161377..75170255, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene ribosomal protein S12, pseudogene 19 Neighboring gene predicted gene, 51907 Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene STARR-positive B cell enhancer ABC_E10686 Neighboring gene microRNA 212 Neighboring gene microRNA 132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis. Burrows K, et al. PLoS Pathog, 2018 Feb. PMID 29470558, Free PMC Article
  2. The transcriptional repressor HIC1 regulates intestinal immune homeostasis. Burrows K, et al. Mucosal Immunol, 2017 Nov. PMID 28327618
  3. Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Pospichalova V, et al. Genesis, 2011 Mar. PMID 21309068
  4. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Chen WY, et al. Nat Genet, 2003 Feb. PMID 12539045
  5. Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Carter MG, et al. Hum Mol Genet, 2000 Feb 12. PMID 10655551

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103[+] intestine-resident memory CD8[+] T cells.
    Title: T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells.
  2. Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.
    Title: Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.
  3. HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
    Title: HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
  4. Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
    Title: Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
  5. Loss of HIC1 in KrasG12D/+(Lox-Stop-Lox)/sgHIC1 mice could promote tumorigenesis.
    Title: Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression.
  6. Loss of Hic1 expression in the early stages of tumor formation may contribute to malignant transformation through the acquisition of chromosomal instability.
    Title: The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
  7. Intestinal innate lymphoid cells express HIC1 in a vitamin A-dependent manner.
    Title: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
  8. this study identified a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions
    Title: The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
  9. HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
    Title: HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
  10. identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins.
    Title: Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hypermethylated in cancer 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098203.1 → NP_001091673.1  hypermethylated in cancer 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001091673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL603905, BU757195, CJ126522
    UniProtKB/Swiss-Prot
    B1ARH0, Q9R1Y5, Q9R1Y6, Q9R2B0
    Related
    ENSMUSP00001091661.1, ENSMUST00000131720.3
    Conserved Domains (6) summary
    smart00225
    Location:48 → 152
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:561 → 609
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:537 → 557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:535 → 557
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:37 → 150
    BTB; BTB/POZ domain
    pfam13465
    Location:578 → 602
    zf-H2C2_2; Zinc-finger double domain

  2. NM_010430.3 → NP_034560.3  hypermethylated in cancer 1 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL603905
    Consensus CDS
    CCDS36226.1
    UniProtKB/TrEMBL
    Z4YJP0
    Related
    ENSMUSP00000053483.6, ENSMUST00000055619.6
    Conserved Domains (5) summary
    COG5048
    Location:482 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18333
    Location:7 → 136
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75052203..75059970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532275.3 → XP_006532338.1  hypermethylated in cancer 1 protein isoform X1

    UniProtKB/TrEMBL
    Z4YJP0
    Conserved Domains (5) summary
    COG5048
    Location:482 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18333
    Location:7 → 136
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1Y5.4 GenPept UniProtKB/Swiss-Prot:Q9R1Y5

Gene LinkOut

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