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CIART circadian associated repressor of transcription [ Homo sapiens (human) ]

Gene ID: 148523, updated on 17-Nov-2018

Summary

Official Symbol
CIARTprovided by HGNC
Official Full Name
circadian associated repressor of transcriptionprovided by HGNC
Primary source
HGNC:HGNC:25200
See related
Ensembl:ENSG00000159208 MIM:615782; Vega:OTTHUMG00000012548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM129; CHRONO; C1orf51
Expression
Broad expression in heart (RPKM 6.9), thyroid (RPKM 5.6) and 24 other tissues See more
Orthologs

Genomic context

See CIART in Genome Data Viewer
Location:
1q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (150282533..150287093)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150254930..150259505)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 14 Neighboring gene small nucleolar RNA, C/D box 13C Neighboring gene aph-1 homolog A, gamma-secretase subunit Neighboring gene chromosome 1 open reading frame 54 Neighboring gene uncharacterized LOC105371434 Neighboring gene mitochondrial ribosomal protein S21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
circadian-associated transcriptional repressor
Names
chIP-derived repressor of network oscillator
computationally highlighted repressor of the network oscillator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300838.1NP_001287767.1  circadian-associated transcriptional repressor isoform a

    See identical proteins and their annotated locations for NP_001287767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC027999, CK904668, EB388133
    Consensus CDS
    CCDS949.1
    UniProtKB/Swiss-Prot
    Q8N365
    Related
    ENSP00000358091.1, OTTHUMP00000014536, ENST00000369095.5, OTTHUMT00000035059
    Conserved Domains (1) summary
    pfam15673
    Location:92368
    Ciart; Circadian-associated transcriptional repressor
  2. NM_001300839.1NP_001287768.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    BC017397, CK904668, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/TrEMBL
    Q5TB12, Q8WVX4
    Related
    ENSP00000358090.1, OTTHUMP00000014537, ENST00000369094.5, OTTHUMT00000035060
    Conserved Domains (1) summary
    pfam15673
    Location:4280
    Ciart; Circadian-associated transcriptional repressor
  3. NM_001300840.1NP_001287769.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    AK056960, CK904668, CN359562, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/Swiss-Prot
    Q8N365
    UniProtKB/TrEMBL
    Q5TB12
    Conserved Domains (1) summary
    pfam15673
    Location:4280
    Ciart; Circadian-associated transcriptional repressor
  4. NM_001300841.1NP_001287770.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    AK056960, BE784098, CK904668, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/Swiss-Prot
    Q8N365
    UniProtKB/TrEMBL
    Q5TB12
    Related
    ENSP00000398291.1, OTTHUMP00000014538, ENST00000417398.5, OTTHUMT00000035061
    Conserved Domains (1) summary
    pfam15673
    Location:4280
    Ciart; Circadian-associated transcriptional repressor
  5. NM_144697.3NP_653298.1  circadian-associated transcriptional repressor isoform a

    See identical proteins and their annotated locations for NP_653298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC242988, BC047238, CK904668, EB388133
    Consensus CDS
    CCDS949.1
    UniProtKB/Swiss-Prot
    Q8N365
    Related
    ENSP00000290363.5, OTTHUMP00000014535, ENST00000290363.5, OTTHUMT00000035058
    Conserved Domains (1) summary
    pfam15673
    Location:92368
    Ciart; Circadian-associated transcriptional repressor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    150282533..150287093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000378.1XP_016855867.1  circadian-associated transcriptional repressor isoform X2

    Conserved Domains (1) summary
    pfam15673
    Location:1211
    DUF4664; Domain of unknown function (DUF4664)
  2. XM_024453375.1XP_024309143.1  circadian-associated transcriptional repressor isoform X1

    Conserved Domains (1) summary
    pfam15673
    Location:4280
    Ciart; Circadian-associated transcriptional repressor
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