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Conserved domains on  [gi|1370452054|ref|XP_024309143|]
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circadian-associated transcriptional repressor isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ciart super family cl24293
Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor ...
4-281 1.52e-176

Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress.


The actual alignment was detected with superfamily member pfam15673:

Pssm-ID: 434847  Cd Length: 278  Bit Score: 488.30  E-value: 1.52e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054   4 SGAKRSRDGELETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 83
Cdd:pfam15673   1 SGVKRSRDGEEETSLNIQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054  84 QMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHLALKPKQPWHLT 163
Cdd:pfam15673  81 EMGERYLGTLLQVEGMLKTWFPHIAAQKSLPGDGRHQLSKRLPSHHTDPTGPSPDLPREKMNQIQLGHLVLKPEQPWHLT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054 164 QWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGE 243
Cdd:pfam15673 161 EWPAMNLTWIHTTPICNPPLSSLGSASFSHGPLGTGTSIGVILFLQHGVQPFTHSAPTTPVPPTTVSPVVCGDPKKLSEE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1370452054 244 GPRCYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQ 281
Cdd:pfam15673 241 GPRCYSLPVTLPSDWSCTLSPPCLPTVAREMTTGHDEK 278
 
Name Accession Description Interval E-value
Ciart pfam15673
Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor ...
4-281 1.52e-176

Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress.


Pssm-ID: 434847  Cd Length: 278  Bit Score: 488.30  E-value: 1.52e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054   4 SGAKRSRDGELETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 83
Cdd:pfam15673   1 SGVKRSRDGEEETSLNIQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054  84 QMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHLALKPKQPWHLT 163
Cdd:pfam15673  81 EMGERYLGTLLQVEGMLKTWFPHIAAQKSLPGDGRHQLSKRLPSHHTDPTGPSPDLPREKMNQIQLGHLVLKPEQPWHLT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054 164 QWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGE 243
Cdd:pfam15673 161 EWPAMNLTWIHTTPICNPPLSSLGSASFSHGPLGTGTSIGVILFLQHGVQPFTHSAPTTPVPPTTVSPVVCGDPKKLSEE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1370452054 244 GPRCYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQ 281
Cdd:pfam15673 241 GPRCYSLPVTLPSDWSCTLSPPCLPTVAREMTTGHDEK 278
 
Name Accession Description Interval E-value
Ciart pfam15673
Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor ...
4-281 1.52e-176

Circadian-associated transcriptional repressor; Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress.


Pssm-ID: 434847  Cd Length: 278  Bit Score: 488.30  E-value: 1.52e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054   4 SGAKRSRDGELETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 83
Cdd:pfam15673   1 SGVKRSRDGEEETSLNIQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054  84 QMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHLALKPKQPWHLT 163
Cdd:pfam15673  81 EMGERYLGTLLQVEGMLKTWFPHIAAQKSLPGDGRHQLSKRLPSHHTDPTGPSPDLPREKMNQIQLGHLVLKPEQPWHLT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452054 164 QWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGE 243
Cdd:pfam15673 161 EWPAMNLTWIHTTPICNPPLSSLGSASFSHGPLGTGTSIGVILFLQHGVQPFTHSAPTTPVPPTTVSPVVCGDPKKLSEE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1370452054 244 GPRCYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQ 281
Cdd:pfam15673 241 GPRCYSLPVTLPSDWSCTLSPPCLPTVAREMTTGHDEK 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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