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ZNF583 zinc finger protein 583 [ Homo sapiens (human) ]

Gene ID: 147949, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF583provided by HGNC
Official Full Name
zinc finger protein 583provided by HGNC
Primary source
HGNC:HGNC:26427
See related
Ensembl:ENSG00000198440 AllianceGenome:HGNC:26427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 1.9), brain (RPKM 1.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZNF583 in Genome Data Viewer
Location:
19q13.43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56404014..56427364)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59498414..59521793)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56915383..56938733)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SLC25A36 pseudogene 1 Neighboring gene zinc finger protein 582 Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 667 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:56968363-56969562 Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  3. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article
  4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31030, MGC133237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 583
Names
zinc finger protein L3-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159860.2 → NP_001153332.1  zinc finger protein 583

    See identical proteins and their annotated locations for NP_001153332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA407197
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Related
    ENSP00000291598.7, ENST00000291598.11
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001159861.2 → NP_001153333.1  zinc finger protein 583

    See identical proteins and their annotated locations for NP_001153333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA942855
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_152478.3 → NP_689691.2  zinc finger protein 583

    See identical proteins and their annotated locations for NP_689691.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA785623
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Related
    ENSP00000388502.2, ENST00000333201.13
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56404014..56427364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438234.1 → XP_047294190.1  zinc finger protein 583 isoform X1

  2. XM_017026350.2 → XP_016881839.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017026349.2 → XP_016881838.1  zinc finger protein 583 isoform X1

  4. XM_011526517.3 → XP_011524819.1  zinc finger protein 583 isoform X3

    See identical proteins and their annotated locations for XP_011524819.1

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047438235.1 → XP_047294191.1  zinc finger protein 583 isoform X1

  6. XM_024451383.2 → XP_024307151.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:209 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_017026346.3 → XP_016881835.1  zinc finger protein 583 isoform X1

  8. XM_017026347.3 → XP_016881836.1  zinc finger protein 583 isoform X1

  9. XM_017026348.2 → XP_016881837.1  zinc finger protein 583 isoform X1

  10. XM_005258558.2 → XP_005258615.1  zinc finger protein 583 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:7 → 67
    KRAB; krueppel associated box
    COG5048
    Location:210 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:215 → 235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:255 → 280
    zf-H2C2_2; Zinc-finger double domain

  11. XM_047438236.1 → XP_047294192.1  zinc finger protein 583 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59498414..59521793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319929.1 → XP_054175904.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8

  2. XM_054319923.1 → XP_054175898.1  zinc finger protein 583 isoform X1

  3. XM_054319930.1 → XP_054175905.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8

  4. XM_054319927.1 → XP_054175902.1  zinc finger protein 583 isoform X1

  5. XM_054319928.1 → XP_054175903.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    O14850, Q2NKK3, Q96ND8

  6. XM_054319922.1 → XP_054175897.1  zinc finger protein 583 isoform X1

  7. XM_054319924.1 → XP_054175899.1  zinc finger protein 583 isoform X1

  8. XM_054319926.1 → XP_054175901.1  zinc finger protein 583 isoform X1

  9. XM_054319925.1 → XP_054175900.1  zinc finger protein 583 isoform X2

  10. XM_054319931.1 → XP_054175906.1  zinc finger protein 583 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96ND8.2 GenPept UniProtKB/Swiss-Prot:Q96ND8

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