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ZNF583 zinc finger protein 583 [ Homo sapiens (human) ]

Gene ID: 147949, updated on 18-Aug-2020

Summary

Official Symbol
ZNF583provided by HGNC
Official Full Name
zinc finger protein 583provided by HGNC
Primary source
HGNC:HGNC:26427
See related
Ensembl:ENSG00000198440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 1.9), brain (RPKM 1.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF583 in Genome Data Viewer
Location:
19q13.43
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56404014..56427364)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56915383..56936400)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SLC25A36 pseudogene 1 Neighboring gene zinc finger protein 582 Neighboring gene ZNF582 divergent transcript Neighboring gene zinc finger protein 667 Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ31030, MGC133237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 583
Names
zinc finger protein L3-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159860.2NP_001153332.1  zinc finger protein 583

    See identical proteins and their annotated locations for NP_001153332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA407197
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    Q96ND8
    Related
    ENSP00000291598.7, ENST00000291598.11
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001159861.2NP_001153333.1  zinc finger protein 583

    See identical proteins and their annotated locations for NP_001153333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA942855
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_152478.3NP_689691.2  zinc finger protein 583

    See identical proteins and their annotated locations for NP_689691.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006116, AK055592, BC111772, DA785623
    Consensus CDS
    CCDS12943.1
    UniProtKB/Swiss-Prot
    Q96ND8
    Related
    ENSP00000388502.2, ENST00000333201.13
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    56404014..56427364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026350.1XP_016881839.1  zinc finger protein 583 isoform X3

    UniProtKB/Swiss-Prot
    Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017026349.1XP_016881838.1  zinc finger protein 583 isoform X1

  3. XM_017026351.2XP_016881840.1  zinc finger protein 583 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:166499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:211236
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017026352.2XP_016881841.1  zinc finger protein 583 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:166499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:211236
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026346.2XP_016881835.1  zinc finger protein 583 isoform X1

  6. XM_017026347.2XP_016881836.1  zinc finger protein 583 isoform X1

  7. XM_024451383.1XP_024307151.1  zinc finger protein 583 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_017026353.1XP_016881842.1  zinc finger protein 583 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:166499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:211236
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011526517.2XP_011524819.1  zinc finger protein 583 isoform X3

    See identical proteins and their annotated locations for XP_011524819.1

    UniProtKB/Swiss-Prot
    Q96ND8
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:209542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_017026348.1XP_016881837.1  zinc finger protein 583 isoform X1

  11. XM_005258558.1XP_005258615.1  zinc finger protein 583 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:210543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:215235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:255280
    zf-H2C2_2; Zinc-finger double domain
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