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ZNF480 zinc finger protein 480 [ Homo sapiens (human) ]

Gene ID: 147657, updated on 5-Jan-2022

Summary

Official Symbol
ZNF480provided by HGNC
Official Full Name
zinc finger protein 480provided by HGNC
Primary source
HGNC:HGNC:23305
See related
Ensembl:ENSG00000198464 MIM:613910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 3.1), lymph node (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF480 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52297169..52325927)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52800422..52829175)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2064 Neighboring gene zinc finger protein 766 Neighboring gene microRNA 643 Neighboring gene zinc finger protein 610 Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene zinc finger protein 528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 480 (ZNF480) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC32104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297624.2NP_001284553.1  zinc finger protein 480 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC010320, AK303271, AL832560, DA501214
    Consensus CDS
    CCDS77346.1
    UniProtKB/Swiss-Prot
    Q8WV37
    UniProtKB/TrEMBL
    B7Z8E1, F8WEZ9
    Related
    ENSP00000334164.6, ENST00000334564.11
    Conserved Domains (6) summary
    smart00349
    Location:2767
    KRAB; krueppel associated box
    COG5048
    Location:115458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:302322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:356378
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:454479
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001297625.2NP_001284554.1  zinc finger protein 480 isoform 3

    See identical proteins and their annotated locations for NP_001284554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010320, AK096442, AL832560, DA501214
    Consensus CDS
    CCDS74437.1
    UniProtKB/Swiss-Prot
    Q8WV37
    Related
    ENSP00000335670.6, ENST00000335090.6
    Conserved Domains (4) summary
    COG5048
    Location:81424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:322344
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  3. NM_144684.4NP_653285.2  zinc finger protein 480 isoform 1

    See identical proteins and their annotated locations for NP_653285.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein.
    Source sequence(s)
    AC010320, AK096442, AK303271, AL832560, AY512662, DA501214
    Consensus CDS
    CCDS12850.2
    UniProtKB/Swiss-Prot
    Q8WV37
    UniProtKB/TrEMBL
    B7Z8E1
    Related
    ENSP00000471754.1, ENST00000595962.6
    Conserved Domains (6) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:158501
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399421
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:497522
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52297169..52325927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526465.2XP_011524767.1  zinc finger protein 480 isoform X1

    See identical proteins and their annotated locations for XP_011524767.1

    UniProtKB/Swiss-Prot
    Q8WV37
    Conserved Domains (6) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:158501
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:345365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399421
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:497522
    zf-H2C2_2; Zinc-finger double domain
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