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WIPF2 WAS/WASL interacting protein family member 2 [ Homo sapiens (human) ]

Gene ID: 147179, updated on 5-Mar-2024

Summary

Official Symbol
WIPF2provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 2provided by HGNC
Primary source
HGNC:HGNC:30923
See related
Ensembl:ENSG00000171475 MIM:609692; AllianceGenome:HGNC:30923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WICH; WIRE
Summary
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.6), colon (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See WIPF2 in Genome Data Viewer
Location:
17q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40219304..40284136)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41083198..41147631)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38375556..38440388)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CASC3 exon junction complex subunit Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38324317-38324876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38332602-38333102 Neighboring gene microRNA 6866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38333103-38333603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38333995-38334850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38334851-38335705 Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38350695-38351195 Neighboring gene microRNA 6867 Neighboring gene Sharpr-MPRA regulatory region 10842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:38375397-38376175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38380779-38381350 Neighboring gene RNY4 pseudogene 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38437298-38438234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38438235-38439169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38443891-38444698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38447656-38448242 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:38452145-38452660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38464859-38465744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38465745-38466628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38468218-38468718 Neighboring gene cell division cycle 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38473742-38473951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38477303-38477887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12143 Neighboring gene retinoic acid receptor alpha Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38497666-38498244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498280-38498830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498831-38499380 Neighboring gene RARA antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag WIRE protein interacts weakly with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
WAS/WASL-interacting protein family member 2
Names
WASP-binding protein
WASP-interacting protein-related protein
WIP- and CR16-homologous protein
WIP-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133264.5NP_573571.1  WAS/WASL-interacting protein family member 2

    See identical proteins and their annotated locations for NP_573571.1

    Status: VALIDATED

    Source sequence(s)
    AC068669, AC080112, AU138315, BC019706, BC043408, BC065551, CB240594, CN404607
    Consensus CDS
    CCDS11364.1
    UniProtKB/Swiss-Prot
    A8K0L3, Q658J8, Q71RE1, Q8TE44, Q8TF74
    Related
    ENSP00000320924.4, ENST00000323571.9
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40219304..40284136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257083.3XP_005257140.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257140.1

    UniProtKB/Swiss-Prot
    A8K0L3, Q658J8, Q71RE1, Q8TE44, Q8TF74
    Related
    ENSP00000462826.1, ENST00000585043.5
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  2. XM_047435499.1XP_047291455.1  WAS/WASL-interacting protein family member 2 isoform X2

  3. XM_047435500.1XP_047291456.1  WAS/WASL-interacting protein family member 2 isoform X3

  4. XM_011524412.1XP_011522714.1  WAS/WASL-interacting protein family member 2 isoform X2

    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  5. XM_005257084.3XP_005257141.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257141.1

    UniProtKB/Swiss-Prot
    A8K0L3, Q658J8, Q71RE1, Q8TE44, Q8TF74
    Related
    ENSP00000462350.1, ENST00000583130.5
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  6. XM_047435498.1XP_047291454.1  WAS/WASL-interacting protein family member 2 isoform X2

  7. XM_047435497.1XP_047291453.1  WAS/WASL-interacting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K0L3, Q658J8, Q71RE1, Q8TE44, Q8TF74
  8. XM_047435496.1XP_047291452.1  WAS/WASL-interacting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K0L3, Q658J8, Q71RE1, Q8TE44, Q8TF74

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41083198..41147631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)