Format

Send to:

Choose Destination

WIPF2 WAS/WASL interacting protein family member 2 [ Homo sapiens (human) ]

Gene ID: 147179, updated on 8-Jul-2021

Summary

Official Symbol
WIPF2provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 2provided by HGNC
Primary source
HGNC:HGNC:30923
See related
Ensembl:ENSG00000171475 MIM:609692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WICH; WIRE
Summary
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.6), colon (RPKM 7.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WIPF2 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40219304..40284136)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38375556..38440388)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CASC3 exon junction complex subunit Neighboring gene microRNA 6866 Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene microRNA 6867 Neighboring gene RNY4 pseudogene 8 Neighboring gene cell division cycle 6 Neighboring gene uncharacterized LOC105371934 Neighboring gene retinoic acid receptor alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag WIRE protein interacts weakly with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
WAS/WASL-interacting protein family member 2
Names
WASP-binding protein
WASP-interacting protein-related protein
WIP- and CR16-homologous protein
WIP-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133264.5NP_573571.1  WAS/WASL-interacting protein family member 2

    See identical proteins and their annotated locations for NP_573571.1

    Status: VALIDATED

    Source sequence(s)
    AC068669, AC080112, AU138315, BC019706, BC043408, BC065551, CB240594, CN404607
    Consensus CDS
    CCDS11364.1
    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000320924.4, ENST00000323571.9
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40219304..40284136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524412.1XP_011522714.1  WAS/WASL-interacting protein family member 2 isoform X2

    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  2. XM_011524413.1XP_011522715.1  WAS/WASL-interacting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011522715.1

    UniProtKB/Swiss-Prot
    Q8TF74
  3. XM_005257083.2XP_005257140.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257140.1

    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000462826.1, ENST00000585043.5
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  4. XM_005257084.2XP_005257141.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257141.1

    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000462350.1, ENST00000583130.5
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
Support Center