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WIPF2 WAS/WASL interacting protein family member 2 [ Homo sapiens (human) ]

Gene ID: 147179, updated on 8-Jul-2018
Official Symbol
WIPF2provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 2provided by HGNC
Primary source
HGNC:HGNC:30923
See related
Ensembl:ENSG00000171475 MIM:609692; Vega:OTTHUMG00000133331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WICH; WIRE
Summary
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.6), colon (RPKM 7.8) and 25 other tissues See more
Orthologs
See WIPF2 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (40219304..40284136)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38375556..38438944)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CASC3, exon junction complex subunit Neighboring gene microRNA 6866 Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene microRNA 6867 Neighboring gene RNA, Ro-associated Y4 pseudogene 8 Neighboring gene cell division cycle 6 Neighboring gene uncharacterized LOC105371934 Neighboring gene retinoic acid receptor alpha

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
capsid gag WIRE protein interacts weakly with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
WAS/WASL-interacting protein family member 2
Names
WASP-binding protein
WASP-interacting protein-related protein
WIP- and CR16-homologous protein
WIP-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133264.4NP_573571.1  WAS/WASL-interacting protein family member 2

    See identical proteins and their annotated locations for NP_573571.1

    Status: VALIDATED

    Source sequence(s)
    AU138315, BC019706, BC043408, BC065551, CB240594, CN404607
    Consensus CDS
    CCDS11364.1
    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000320924.4, OTTHUMP00000164467, ENST00000323571.8, OTTHUMT00000257157
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    40219304..40284136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524412.1XP_011522714.1  WAS/WASL-interacting protein family member 2 isoform X2

    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  2. XM_011524413.1XP_011522715.1  WAS/WASL-interacting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011522715.1

    UniProtKB/Swiss-Prot
    Q8TF74
  3. XM_005257083.2XP_005257140.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257140.1

    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000462826.1, OTTHUMP00000262019, ENST00000585043.5, OTTHUMT00000447432
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
  4. XM_005257084.2XP_005257141.1  WAS/WASL-interacting protein family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005257141.1

    UniProtKB/Swiss-Prot
    Q8TF74
    Related
    ENSP00000462350.1, OTTHUMP00000262020, ENST00000583130.5, OTTHUMT00000447433
    Conserved Domains (1) summary
    pfam02205
    Location:3660
    WH2; WH2 motif
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