U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wipf2 WAS/WASL interacting protein family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 68524, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Wipf2provided by MGI
Official Full Name
WAS/WASL interacting protein family, member 2provided by MGI
Primary source
MGI:MGI:1924462
See related
Ensembl:ENSMUSG00000038013 AllianceGenome:MGI:1924462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wich; Wire; Gm1176; 1110014J05Rik; 5730509C05Rik
Summary
Predicted to enable actin binding activity. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human WIPF2 (WAS/WASL interacting protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), cortex adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Wipf2 in Genome Data Viewer
Location:
11 D; 11 62.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98754424..98796404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98863598..98905578)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5276 Neighboring gene predicted gene 12359 Neighboring gene exon junction complex subunit Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9145 Neighboring gene VISTA enhancer mm1323 Neighboring gene STARR-positive B cell enhancer ABC_E203 Neighboring gene cell division cycle 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98803426-98803613 Neighboring gene retinoic acid receptor, alpha Neighboring gene predicted gene, 46294

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Garber JJ, et al. Infect Immun, 2012 Dec. PMID 22966049, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WAS/WASL-interacting protein family member 2
Names
WASP-binding protein
WASP-interacting protein-related protein
WIP-related protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197940.2 → NP_922922.1  WAS/WASL-interacting protein family member 2

    See identical proteins and their annotated locations for NP_922922.1

    Status: VALIDATED

    Source sequence(s)
    AL591067
    Consensus CDS
    CCDS25366.1
    UniProtKB/Swiss-Prot
    Q6PEV3
    Related
    ENSMUSP00000046991.9, ENSMUST00000037480.9
    Conserved Domains (3) summary
    PRK12323
    Location:60 → 220
    PRK12323; DNA polymerase III subunit gamma/tau
    cd21762
    Location:50 → 53
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:33 → 62
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98754424..98796404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEV3.1 GenPept UniProtKB/Swiss-Prot:Q6PEV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools