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CSNK1E casein kinase 1 epsilon [ Homo sapiens (human) ]

Gene ID: 1454, updated on 14-Jun-2020

Summary

Official Symbol
CSNK1Eprovided by HGNC
Official Full Name
casein kinase 1 epsilonprovided by HGNC
Primary source
HGNC:HGNC:2453
See related
Ensembl:ENSG00000213923 MIM:600863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKIe; HCKIE; CKIepsilon
Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in brain (RPKM 32.2), endometrium (RPKM 32.2) and 25 other tissues See more
Orthologs

Genomic context

See CSNK1E in Genome Data Viewer
Location:
22q13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38290691..38318084, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38686697..38714089, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184B Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene TPTEP2-CSNK1E readthrough Neighboring gene TPTE pseudogene 2 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TPTEP2-CSNK1E

Readthrough gene: TPTEP2-CSNK1E, Included gene: TPTEP2

Homology

Clone Names

  • MGC10398

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of non-canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
casein kinase I isoform epsilon
NP_001885.1
NP_689407.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016707.1 RefSeqGene

    Range
    5001..32393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001894.4NP_001885.1  casein kinase I isoform epsilon

    See identical proteins and their annotated locations for NP_001885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB024597, BC013088, BU517079
    Consensus CDS
    CCDS13970.1
    UniProtKB/Swiss-Prot
    P49674
    UniProtKB/TrEMBL
    Q5U045
    Related
    ENSP00000352929.3, ENST00000359867.7
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. NM_152221.3NP_689407.1  casein kinase I isoform epsilon

    See identical proteins and their annotated locations for NP_689407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer and predominant transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL020993, BC006490, BC013088, BQ642398, BU517079, CF594072
    Consensus CDS
    CCDS13970.1
    UniProtKB/Swiss-Prot
    P49674
    UniProtKB/TrEMBL
    Q5U045
    Related
    ENSP00000380044.1, ENST00000396832.6
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38290691..38318084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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