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Csnk1e casein kinase 1, epsilon [ Mus musculus (house mouse) ]

Gene ID: 27373, updated on 8-Sep-2018

Summary

Official Symbol
Csnk1eprovided by MGI
Official Full Name
casein kinase 1, epsilonprovided by MGI
Primary source
MGI:MGI:1351660
See related
Ensembl:ENSMUSG00000022433 Vega:OTTMUSG00000029589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tau; CKIe; AI426939; AI551861; AW457082; CK1epsilon; KC1epsilon
Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more

Genomic context

See Csnk1e in Genome Data Viewer
Location:
15; 15 E1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79417852..79455579, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79248282..79272487, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
circadian behavior ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
casein kinase I isoform epsilon; casein kinase I
Names
CKI-epsilon
KC1 epsilon
NP_001276827.1
NP_001276828.1
NP_038795.3
XP_006521106.1
XP_011243951.1
XP_011243952.1
XP_011243953.1
XP_011243954.1
XP_011243955.1
XP_011243956.1
XP_017172146.1
XP_017172147.1
XP_017172148.1
XP_017172149.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289898.1NP_001276827.1  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_001276827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AL591913
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q9JMK2
    Related
    ENSMUSP00000113341.1, OTTMUSP00000037966, ENSMUST00000117786.7, OTTMUST00000073380
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. NM_001289899.1NP_001276828.1  casein kinase I isoform epsilon isoform b

    See identical proteins and their annotated locations for NP_001276828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK158709
    Consensus CDS
    CCDS70646.1
    UniProtKB/TrEMBL
    Q3TYE1
    Related
    ENSMUSP00000113096.1, OTTMUSP00000037967, ENSMUST00000122044.7, OTTMUST00000073381
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. NM_001359862.1NP_001346791.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AL591913
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. NM_001359863.1NP_001346792.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AL591913
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. NM_013767.6NP_038795.3  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_038795.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AL591913
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q9JMK2
    Related
    ENSMUSP00000113975.1, OTTMUSP00000037968, ENSMUST00000120859.7, OTTMUST00000073382
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    79417852..79455579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245651.1XP_011243953.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243953.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. XM_011245652.2XP_011243954.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243954.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. XM_017316658.1XP_017172147.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q9JMK2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. XM_011245649.1XP_011243951.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243951.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. XM_011245653.2XP_011243955.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243955.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  6. XM_017316659.1XP_017172148.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q9JMK2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  7. XM_011245654.2XP_011243956.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243956.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  8. XM_011245650.2XP_011243952.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243952.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  9. XM_006521043.3XP_006521106.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006521106.1

    Conserved Domains (2) summary
    COG0515
    Location:8285
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  10. XM_017316657.1XP_017172146.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q9JMK2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  11. XM_017316660.1XP_017172149.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    Q3TYE1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
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