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Csnk1e casein kinase 1, epsilon [ Mus musculus (house mouse) ]

Gene ID: 27373, updated on 12-Jun-2022

Summary

Official Symbol
Csnk1eprovided by MGI
Official Full Name
casein kinase 1, epsilonprovided by MGI
Primary source
MGI:MGI:1351660
See related
Ensembl:ENSMUSG00000022433 AllianceGenome:MGI:1351660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tau; CKIe; AI426939; AI551861; AW457082; CK1epsilon; KC1epsilon
Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more
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Genomic context

See Csnk1e in Genome Data Viewer
Location:
15; 15 E1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79302052..79339779, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79417852..79455579, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79248282..79272487, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene predicted gene 16059 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
casein kinase I isoform epsilon; casein kinase I
Names
CKI-epsilon
KC1 epsilon
NP_001276827.1
NP_001276828.1
NP_001346791.1
NP_001346792.1
NP_038795.3
XP_006521106.1
XP_011243951.1
XP_011243952.1
XP_011243953.1
XP_011243954.1
XP_011243955.1
XP_011243956.1
XP_017172146.1
XP_017172149.1
XP_030104453.1
XP_030104454.1
XP_030104455.1
XP_030104456.1
XP_030104457.1
XP_030104458.1
XP_030104459.1
XP_030104460.1
XP_036015339.1
XP_036015340.1
XP_036015341.1
XP_036015342.1
XP_036015343.1
XP_036015344.1
XP_036015345.1
XP_036015346.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289898.2NP_001276827.1  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_001276827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q9JMK2
    Related
    ENSMUSP00000113341.2, ENSMUST00000117786.9
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. NM_001289899.1NP_001276828.1  casein kinase I isoform epsilon isoform b

    See identical proteins and their annotated locations for NP_001276828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK158709
    Consensus CDS
    CCDS70646.1
    UniProtKB/TrEMBL
    Q3TYE1
    Related
    ENSMUSP00000113096.2, ENSMUST00000122044.8
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. NM_001359862.1NP_001346791.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. NM_001359863.1NP_001346792.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. NM_013767.7NP_038795.3  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_038795.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q9JMK2
    Related
    ENSMUSP00000113975.2, ENSMUST00000120859.9
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79302052..79339779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245651.2XP_011243953.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243953.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. XM_036159448.1XP_036015341.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. XM_011245652.3XP_011243954.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243954.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. XM_011245649.3XP_011243951.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243951.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. XM_030248598.2XP_030104458.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  6. XM_011245653.4XP_011243955.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243955.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  7. XM_017316657.2XP_017172146.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q9JMK2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  8. XM_006521043.4XP_006521106.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006521106.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  9. XM_030248596.1XP_030104456.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  10. XM_036159446.1XP_036015339.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  11. XM_036159451.1XP_036015344.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  12. XM_011245650.4XP_011243952.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243952.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  13. XM_030248593.1XP_030104453.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  14. XM_030248595.2XP_030104455.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  15. XM_036159453.1XP_036015346.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  16. XM_036159447.1XP_036015340.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  17. XM_011245654.4XP_011243956.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243956.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  18. XM_036159450.1XP_036015343.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  19. XM_030248594.1XP_030104454.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  20. XM_036159452.1XP_036015345.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  21. XM_036159449.1XP_036015342.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  22. XM_030248597.2XP_030104457.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  23. XM_030248599.2XP_030104459.1  casein kinase I isoform X3

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  24. XM_030248600.2XP_030104460.1  casein kinase I isoform X3

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  25. XM_017316660.2XP_017172149.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    Q3TYE1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon