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Ptk2 PTK2 protein tyrosine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 14083, updated on 7-Oct-2018

Summary

Official Symbol
Ptk2provided by MGI
Official Full Name
PTK2 protein tyrosine kinase 2provided by MGI
Primary source
MGI:MGI:95481
See related
Ensembl:ENSMUSG00000022607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAK; FRNK; Fadk; FADK 1; p125FAK
Expression
Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues See more
Orthologs

Genomic context

See Ptk2 in Genome Data Viewer
Location:
15 D3; 15 33.94 cM
Exon count:
41
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (73205102..73423275, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (73035535..73253621, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene chromatin accessibility complex 1 Neighboring gene predicted gene, 31725 Neighboring gene argonaute RISC catalytic subunit 2 Neighboring gene microRNA 151 Neighboring gene predicted gene, 41344 Neighboring gene protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4203

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
signal complex assembly IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
intercalated disc ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
focal adhesion kinase 1
Names
focal adhesion kinase-related nonkinase
focal ashension kinase 1
pp125FAK
protein-tyrosine kinase 2
NP_032008.2
XP_006520478.1
XP_006520479.1
XP_006520481.1
XP_006520483.1
XP_006520484.1
XP_006520485.1
XP_006520486.1
XP_006520487.1
XP_006520488.1
XP_006520489.1
XP_006520490.1
XP_006520491.1
XP_006520492.1
XP_006520493.1
XP_006520494.1
XP_006520495.1
XP_006520496.1
XP_006520497.1
XP_006520498.1
XP_011243754.1
XP_011243755.1
XP_017171917.1
XP_017171918.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358045.1NP_001344974.1  focal adhesion kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate exons in the 5' UTR and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC121319, AC132863, AC161581
  2. NM_001358046.1NP_001344975.1  focal adhesion kinase 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
    Source sequence(s)
    AC121319, AC132863, AC161581
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  3. NM_007982.2NP_032008.2  focal adhesion kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_032008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK220543, BB816209
    Consensus CDS
    CCDS37099.1
    UniProtKB/Swiss-Prot
    P34152
    Related
    ENSMUSP00000105663.2, ENSMUST00000110036.10
    Conserved Domains (6) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9161045
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:422676
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    73205102..73423275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520426.2XP_006520489.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520489.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006520430.2XP_006520493.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520493.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_006520431.2XP_006520494.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520494.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_006520435.3XP_006520498.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520498.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_006520424.2XP_006520487.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520487.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_006520416.2XP_006520479.1  focal adhesion kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006520479.1

    Conserved Domains (6) summary
    cd05056
    Location:500769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:10041133
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:507761
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_006520425.2XP_006520488.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520488.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_006520415.2XP_006520478.1  focal adhesion kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006520478.1

    Conserved Domains (6) summary
    cd05056
    Location:500769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:10041133
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:507761
    Pkinase_Tyr; Protein tyrosine kinase
  9. XM_006520429.2XP_006520492.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520492.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  10. XM_006520428.2XP_006520491.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520491.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  11. XM_006520427.3XP_006520490.1  focal adhesion kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006520490.1

    Conserved Domains (6) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:463717
    Pkinase_Tyr; Protein tyrosine kinase
  12. XM_006520434.2XP_006520497.1  focal adhesion kinase 1 isoform X13

    Conserved Domains (6) summary
    cd05056
    Location:355624
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:16157
    B41; Band 4.1 homologues
    cd13190
    Location:153263
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:42147
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:859988
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:362616
    Pkinase_Tyr; Protein tyrosine kinase
  13. XM_017316429.1XP_017171918.1  focal adhesion kinase 1 isoform X11

    UniProtKB/TrEMBL
    K7Q751
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  14. XM_006520433.2XP_006520496.1  focal adhesion kinase 1 isoform X12

    UniProtKB/Swiss-Prot
    P34152
    Related
    ENSMUSP00000154242.1, ENSMUST00000226988.2
    Conserved Domains (6) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9191048
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:422676
    Pkinase_Tyr; Protein tyrosine kinase
  15. XM_006520423.1XP_006520486.1  focal adhesion kinase 1 isoform X8

    Conserved Domains (4) summary
    cd05056
    Location:459728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9631092
    Focal_AT; Focal adhesion targeting region
  16. XM_006520422.1XP_006520485.1  focal adhesion kinase 1 isoform X8

    See identical proteins and their annotated locations for XP_006520485.1

    Conserved Domains (4) summary
    cd05056
    Location:459728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9631092
    Focal_AT; Focal adhesion targeting region
  17. XM_006520421.1XP_006520484.1  focal adhesion kinase 1 isoform X6

    Conserved Domains (6) summary
    cd05056
    Location:466735
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9701099
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:473727
    Pkinase_Tyr; Protein tyrosine kinase
  18. XM_006520420.1XP_006520483.1  focal adhesion kinase 1 isoform X5

    Conserved Domains (6) summary
    cd05056
    Location:472741
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9761105
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:479733
    Pkinase_Tyr; Protein tyrosine kinase
  19. XM_006520418.1XP_006520481.1  focal adhesion kinase 1 isoform X3

    Conserved Domains (6) summary
    cd05056
    Location:493762
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9971126
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:500754
    Pkinase_Tyr; Protein tyrosine kinase
  20. XM_011245453.1XP_011243755.1  focal adhesion kinase 1 isoform X4

    Conserved Domains (6) summary
    cd05056
    Location:500769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9831112
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:507761
    Pkinase_Tyr; Protein tyrosine kinase
  21. XM_006520432.2XP_006520495.1  focal adhesion kinase 1 isoform X10

    Conserved Domains (6) summary
    cd05056
    Location:459728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:466720
    Pkinase_Tyr; Protein tyrosine kinase
  22. XM_017316428.1XP_017171917.1  focal adhesion kinase 1 isoform X7

  23. XM_011245452.2XP_011243754.1  focal adhesion kinase 1 isoform X2

    Conserved Domains (6) summary
    cd05056
    Location:500769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:187292
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:10011130
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:507761
    Pkinase_Tyr; Protein tyrosine kinase

RNA

  1. XR_383981.2 RNA Sequence

  2. XR_001781493.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130409.1: Suppressed sequence

    Description
    NM_001130409.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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