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PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 5747, updated on 17-May-2020

Summary

Official Symbol
PTK2provided by HGNC
Official Full Name
protein tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:9611
See related
Ensembl:ENSG00000169398 MIM:600758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See PTK2 in Genome Data Viewer
Location:
8q24.3
Exon count:
44
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (140657900..141002079, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141668481..142011412, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene MAGE-like protein 2 Neighboring gene microRNA 151a Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene uncharacterized LOC105375783 Neighboring gene Sharpr-MPRA regulatory region 11335 Neighboring gene uncharacterized LOC105375784

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
PubMed 
cell motility TAS
Traceable Author Statement
more info
PubMed 
central nervous system neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
heart morphogenesis TAS
Traceable Author Statement
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
netrin-activated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
nuclear migration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
placenta development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of GTPase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
PubMed 
signal complex assembly IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
focal adhesion kinase 1
Names
FADK 1
FAK-related non-kinase polypeptide
PTK2 protein tyrosine kinase 2
focal adhesion kinase isoform FAK-Del33
focal adhesion kinase-related nonkinase
protein phosphatase 1 regulatory subunit 71
NP_001186578.1
NP_001303271.1
NP_001339623.1
NP_001339624.1
NP_001339625.1
NP_001339626.1
NP_001339627.1
NP_001339628.1
NP_001339629.1
NP_001339630.1
NP_001339631.1
NP_001339632.1
NP_001339633.1
NP_001339634.1
NP_001339635.1
NP_001339636.1
NP_001339637.1
NP_001339638.1
NP_001339639.1
NP_001339640.1
NP_001339641.1
NP_001339642.1
NP_001339643.1
NP_001339644.1
NP_001339645.1
NP_001339646.1
NP_001339647.1
NP_001339648.1
NP_001339649.1
NP_001339650.1
NP_001339651.1
NP_001339652.1
NP_001339653.1
NP_001339654.1
NP_001339655.1
NP_001339656.1
NP_001339657.1
NP_001339658.1
NP_001339659.1
NP_001339660.1
NP_001339661.1
NP_001339662.1
NP_001339663.1
NP_001339664.1
NP_001339665.1
NP_001339666.1
NP_001339667.1
NP_001339668.1
NP_001339669.1
NP_001339670.1
NP_001339671.1
NP_001339672.1
NP_001339673.1
NP_001339674.1
NP_001339675.1
NP_001339676.1
NP_001339677.1
NP_001339678.1
NP_001339679.1
NP_001339680.1
NP_001339681.1
NP_005598.3
NP_722560.1
XP_016869142.1
XP_016869143.1
XP_016869145.1
XP_016869146.1
XP_016869153.1
XP_016869155.1
XP_016869158.1
XP_016869173.1
XP_016869177.1
XP_024302967.1
XP_024302968.1
XP_024302969.1
XP_024302970.1
XP_024302971.1
XP_024302972.1
XP_024302973.1
XP_024302974.1
XP_024302975.1
XP_024302976.1
XP_024302977.1
XP_024302978.1
XP_024302979.1
XP_024302980.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029467.2 RefSeqGene

    Range
    5032..348414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199649.2NP_001186578.1  focal adhesion kinase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
    Source sequence(s)
    AB209083, AC067931, AK304356, AL832961, BF434494, DA236314, DA994616
    Consensus CDS
    CCDS56557.1
    UniProtKB/Swiss-Prot
    Q05397
    UniProtKB/TrEMBL
    Q59GM6, Q658W2
    Related
    ENSP00000341189.3, ENST00000340930.7
    Conserved Domains (6) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9291058
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:422676
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001316342.2NP_001303271.1  focal adhesion kinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and contains two other alternate in-frame exons compared to variant 2. The resulting isoform (d) differs in the 5' UTR, has a shorter and distinct N-terminus, and contains two alternative segments compared to isoform b. Variants 4 and 7 both encode the same isoform (d).
    Source sequence(s)
    AB209071, AC067931, BF434494, BY800117
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:819948
    Focal_AT; Focal adhesion targeting region
  3. NM_001352694.2NP_001339623.1  focal adhesion kinase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    Related
    ENSP00000429474.1, ENST00000521059.5
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9161045
    Focal_AT; Focal adhesion targeting region
  4. NM_001352695.2NP_001339624.1  focal adhesion kinase 1 isoform vv

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:449718
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9291058
    Focal_AT; Focal adhesion targeting region
  5. NM_001352696.2NP_001339625.1  focal adhesion kinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:315584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:819948
    Focal_AT; Focal adhesion targeting region
  6. NM_001352697.2NP_001339626.1  focal adhesion kinase 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:500769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80302
    B41; Band 4.1 homologues
    cd13190
    Location:298408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9801109
    Focal_AT; Focal adhesion targeting region
  7. NM_001352698.2NP_001339627.1  focal adhesion kinase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:469738
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49271
    B41; Band 4.1 homologues
    cd13190
    Location:267377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9731102
    Focal_AT; Focal adhesion targeting region
  8. NM_001352699.2NP_001339628.1  focal adhesion kinase 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 11-14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
  9. NM_001352700.2NP_001339629.1  focal adhesion kinase 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12-14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
  10. NM_001352701.2NP_001339630.1  focal adhesion kinase 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 10, 11, 13, and 14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
  11. NM_001352702.2NP_001339631.1  focal adhesion kinase 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 10-12 and 14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
  12. NM_001352703.2NP_001339632.1  focal adhesion kinase 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 10-13, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9601089
    Focal_AT; Focal adhesion targeting region
  13. NM_001352704.2NP_001339633.1  focal adhesion kinase 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:449718
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9531082
    Focal_AT; Focal adhesion targeting region
  14. NM_001352705.2NP_001339634.1  focal adhesion kinase 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:441710
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49271
    B41; Band 4.1 homologues
    cd13190
    Location:267377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9451074
    Focal_AT; Focal adhesion targeting region
  15. NM_001352706.2NP_001339635.1  focal adhesion kinase 1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 18-21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  16. NM_001352707.2NP_001339636.1  focal adhesion kinase 1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 17 and 19-21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  17. NM_001352708.2NP_001339637.1  focal adhesion kinase 1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 17,18, 20, and 21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  18. NM_001352709.2NP_001339638.1  focal adhesion kinase 1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 17-19 and 21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  19. NM_001352710.2NP_001339639.1  focal adhesion kinase 1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 17-20, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321061
    Focal_AT; Focal adhesion targeting region
  20. NM_001352711.2NP_001339640.1  focal adhesion kinase 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:427696
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9311060
    Focal_AT; Focal adhesion targeting region
  21. NM_001352712.2NP_001339641.1  focal adhesion kinase 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:456725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9571086
    Focal_AT; Focal adhesion targeting region
  22. NM_001352713.2NP_001339642.1  focal adhesion kinase 1 isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:422691
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9261055
    Focal_AT; Focal adhesion targeting region
  23. NM_001352714.2NP_001339643.1  focal adhesion kinase 1 isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:422691
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9261055
    Focal_AT; Focal adhesion targeting region
  24. NM_001352715.2NP_001339644.1  focal adhesion kinase 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:421690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9251054
    Focal_AT; Focal adhesion targeting region
  25. NM_001352716.2NP_001339645.1  focal adhesion kinase 1 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:420689
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9241053
    Focal_AT; Focal adhesion targeting region
  26. NM_001352717.2NP_001339646.1  focal adhesion kinase 1 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:421690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9221051
    Focal_AT; Focal adhesion targeting region
  27. NM_001352718.2NP_001339647.1  focal adhesion kinase 1 isoform q

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9191048
    Focal_AT; Focal adhesion targeting region
  28. NM_001352719.2NP_001339648.1  focal adhesion kinase 1 isoform q

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9191048
    Focal_AT; Focal adhesion targeting region
  29. NM_001352720.2NP_001339649.1  focal adhesion kinase 1 isoform q

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9191048
    Focal_AT; Focal adhesion targeting region
  30. NM_001352721.2NP_001339650.1  focal adhesion kinase 1 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9111040
    Focal_AT; Focal adhesion targeting region
  31. NM_001352722.2NP_001339651.1  focal adhesion kinase 1 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9111040
    Focal_AT; Focal adhesion targeting region
  32. NM_001352723.2NP_001339652.1  focal adhesion kinase 1 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9111040
    Focal_AT; Focal adhesion targeting region
  33. NM_001352724.2NP_001339653.1  focal adhesion kinase 1 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9321034
    Focal_AT; Focal adhesion targeting region
  34. NM_001352725.2NP_001339654.1  focal adhesion kinase 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8981027
    Focal_AT; Focal adhesion targeting region
  35. NM_001352726.2NP_001339655.1  focal adhesion kinase 1 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:392661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8961025
    Focal_AT; Focal adhesion targeting region
  36. NM_001352727.2NP_001339656.1  focal adhesion kinase 1 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:428697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9111013
    Focal_AT; Focal adhesion targeting region
  37. NM_001352728.2NP_001339657.1  focal adhesion kinase 1 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:379648
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8801009
    Focal_AT; Focal adhesion targeting region
  38. NM_001352729.2NP_001339658.1  focal adhesion kinase 1 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:392661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8751004
    Focal_AT; Focal adhesion targeting region
  39. NM_001352730.2NP_001339659.1  focal adhesion kinase 1 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:343612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:847976
    Focal_AT; Focal adhesion targeting region
  40. NM_001352731.2NP_001339660.1  focal adhesion kinase 1 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:343612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:845974
    Focal_AT; Focal adhesion targeting region
  41. NM_001352732.2NP_001339661.1  focal adhesion kinase 1 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:343612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:844973
    Focal_AT; Focal adhesion targeting region
  42. NM_001352733.2NP_001339662.1  focal adhesion kinase 1 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:336605
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:840969
    Focal_AT; Focal adhesion targeting region
  43. NM_001352734.2NP_001339663.1  focal adhesion kinase 1 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:343612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:826955
    Focal_AT; Focal adhesion targeting region
  44. NM_001352735.2NP_001339664.1  focal adhesion kinase 1 isoform tt

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:322591
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9124
    B41; Band 4.1 homologues
    cd13190
    Location:120230
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:826955
    Focal_AT; Focal adhesion targeting region
  45. NM_001352736.2NP_001339665.1  focal adhesion kinase 1 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:320589
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:16157
    B41; Band 4.1 homologues
    cd13190
    Location:153263
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:824953
    Focal_AT; Focal adhesion targeting region
  46. NM_001352737.2NP_001339666.1  focal adhesion kinase 1 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:336605
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:837966
    Focal_AT; Focal adhesion targeting region
  47. NM_001352738.2NP_001339667.1  focal adhesion kinase 1 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:315584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:817946
    Focal_AT; Focal adhesion targeting region
  48. NM_001352739.2NP_001339668.1  focal adhesion kinase 1 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:309578
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:813942
    Focal_AT; Focal adhesion targeting region
  49. NM_001352740.2NP_001339669.1  focal adhesion kinase 1 isoform hh

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:308577
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:812941
    Focal_AT; Focal adhesion targeting region
  50. NM_001352741.2NP_001339670.1  focal adhesion kinase 1 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:302571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:806935
    Focal_AT; Focal adhesion targeting region
  51. NM_001352742.2NP_001339671.1  focal adhesion kinase 1 isoform jj

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:294563
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9124
    B41; Band 4.1 homologues
    cd13190
    Location:120230
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:798927
    Focal_AT; Focal adhesion targeting region
  52. NM_001352743.2NP_001339672.1  focal adhesion kinase 1 isoform uu

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:315584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:798927
    Focal_AT; Focal adhesion targeting region
  53. NM_001352744.2NP_001339673.1  focal adhesion kinase 1 isoform kk

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:279548
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:783912
    Focal_AT; Focal adhesion targeting region
  54. NM_001352745.2NP_001339674.1  focal adhesion kinase 1 isoform ll

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Conserved Domains (4) summary
    cd05056
    Location:273542
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:777906
    Focal_AT; Focal adhesion targeting region
  55. NM_001352746.2NP_001339675.1  focal adhesion kinase 1 isoform mm

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Related
    ENSP00000428492.1, ENST00000523539.5
    Conserved Domains (4) summary
    cd05056
    Location:258527
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9124
    B41; Band 4.1 homologues
    cd13190
    Location:120194
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:762891
    Focal_AT; Focal adhesion targeting region
  56. NM_001352747.2NP_001339676.1  focal adhesion kinase 1 isoform nn

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Related
    ENSP00000429170.1, ENST00000519465.5
    Conserved Domains (2) summary
    pfam03623
    Location:445574
    Focal_AT; Focal adhesion targeting region
    cl21453
    Location:1210
    PKc_like; Protein Kinases, catalytic domain
  57. NM_001352748.2NP_001339677.1  focal adhesion kinase 1 isoform oo

    Status: REVIEWED

    Source sequence(s)
    AC100860, AC105009, AC105235
    Conserved Domains (3) summary
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cl21453
    Location:428496
    PKc_like; Protein Kinases, catalytic domain
  58. NM_001352749.2NP_001339678.1  focal adhesion kinase 1 isoform pp

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:229358
    Focal_AT; Focal adhesion targeting region
  59. NM_001352750.2NP_001339679.1  focal adhesion kinase 1 isoform qq

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Consensus CDS
    CCDS87628.1
    Related
    ENSP00000403416.2, ENST00000430260.6
    Conserved Domains (1) summary
    pfam03623
    Location:226355
    Focal_AT; Focal adhesion targeting region
  60. NM_001352751.2NP_001339680.1  focal adhesion kinase 1 isoform rr

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:208337
    Focal_AT; Focal adhesion targeting region
  61. NM_001352752.2NP_001339681.1  focal adhesion kinase 1 isoform ss

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:205334
    Focal_AT; Focal adhesion targeting region
  62. NM_005607.5NP_005598.3  focal adhesion kinase 1 isoform b

    See identical proteins and their annotated locations for NP_005598.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform b.
    Source sequence(s)
    AB209083, AC067931, AC100860, AL832961, BF434494, DA236314
    UniProtKB/TrEMBL
    Q59GM6, Q658W2
    Conserved Domains (6) summary
    cd05056
    Location:437706
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:58280
    B41; Band 4.1 homologues
    cd13190
    Location:276386
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:165270
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:9381067
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:444698
    Pkinase_Tyr; Protein tyrosine kinase
  63. NM_153831.4NP_722560.1  focal adhesion kinase 1 isoform a

    See identical proteins and their annotated locations for NP_722560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1 and 5 both encode the same isoform (a).
    Source sequence(s)
    AB209083, AC067931, AL832961, BF434494, DA236314, L13616
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    Q05397
    UniProtKB/TrEMBL
    Q59GM6, Q658W2
    Related
    ENSP00000429911.1, ENST00000522684.5
    Conserved Domains (4) summary
    cd05056
    Location:415684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9161045
    Focal_AT; Focal adhesion targeting region

RNA

  1. NR_148036.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
  2. NR_148037.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
  3. NR_148038.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Related
    ENST00000519993.5
  4. NR_148039.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    140657900..141002079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447210.1XP_024302978.1  focal adhesion kinase 1 isoform X16

    Conserved Domains (4) summary
    cd05056
    Location:443712
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305379
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9261055
    Focal_AT; Focal adhesion targeting region
  2. XM_024447207.1XP_024302975.1  focal adhesion kinase 1 isoform X13

    Conserved Domains (4) summary
    cd05056
    Location:466735
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9491078
    Focal_AT; Focal adhesion targeting region
  3. XM_024447206.1XP_024302974.1  focal adhesion kinase 1 isoform X12

    Conserved Domains (4) summary
    cd05056
    Location:479748
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9621091
    Focal_AT; Focal adhesion targeting region
  4. XM_024447205.1XP_024302973.1  focal adhesion kinase 1 isoform X9

    Conserved Domains (4) summary
    cd05056
    Location:466735
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9671096
    Focal_AT; Focal adhesion targeting region
  5. XM_024447203.1XP_024302971.1  focal adhesion kinase 1 isoform X6

    Conserved Domains (4) summary
    cd05056
    Location:472741
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9731102
    Focal_AT; Focal adhesion targeting region
  6. XM_017013666.1XP_016869155.1  focal adhesion kinase 1 isoform X18

  7. XM_017013669.2XP_016869158.1  focal adhesion kinase 1 isoform X19

  8. XM_024447202.1XP_024302970.1  focal adhesion kinase 1 isoform X5

    Conserved Domains (4) summary
    cd05056
    Location:473742
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9741103
    Focal_AT; Focal adhesion targeting region
  9. XM_017013656.2XP_016869145.1  focal adhesion kinase 1 isoform X10

    Related
    ENSP00000429082.1, ENST00000517887.5
  10. XM_017013688.2XP_016869177.1  focal adhesion kinase 1 isoform X23

    Conserved Domains (4) summary
    cd05056
    Location:279548
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:783912
    Focal_AT; Focal adhesion targeting region
  11. XM_017013684.2XP_016869173.1  focal adhesion kinase 1 isoform X21

    Conserved Domains (4) summary
    cd05056
    Location:309578
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:813942
    Focal_AT; Focal adhesion targeting region
  12. XM_024447211.1XP_024302979.1  focal adhesion kinase 1 isoform X20

    Conserved Domains (4) summary
    cd05056
    Location:392661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8961025
    Focal_AT; Focal adhesion targeting region
  13. XM_024447209.1XP_024302977.1  focal adhesion kinase 1 isoform X15

    Conserved Domains (4) summary
    cd05056
    Location:437706
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305379
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9411070
    Focal_AT; Focal adhesion targeting region
  14. XM_024447208.1XP_024302976.1  focal adhesion kinase 1 isoform X14

    Conserved Domains (4) summary
    cd05056
    Location:443712
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305379
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9471076
    Focal_AT; Focal adhesion targeting region
  15. XM_024447200.1XP_024302968.1  focal adhesion kinase 1 isoform X2

    Conserved Domains (4) summary
    cd05056
    Location:473742
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9771106
    Focal_AT; Focal adhesion targeting region
  16. XM_024447199.1XP_024302967.1  focal adhesion kinase 1 isoform X1

    Conserved Domains (4) summary
    cd05056
    Location:479748
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9831112
    Focal_AT; Focal adhesion targeting region
  17. XM_017013654.2XP_016869143.1  focal adhesion kinase 1 isoform X8

  18. XM_017013653.2XP_016869142.1  focal adhesion kinase 1 isoform X4

  19. XM_024447212.1XP_024302980.1  focal adhesion kinase 1 isoform X22

    Conserved Domains (4) summary
    cd05056
    Location:302571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9145
    B41; Band 4.1 homologues
    cd13190
    Location:141251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:806935
    Focal_AT; Focal adhesion targeting region
  20. XM_017013664.2XP_016869153.1  focal adhesion kinase 1 isoform X17

    Conserved Domains (4) summary
    cd05056
    Location:421690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36258
    B41; Band 4.1 homologues
    cd13190
    Location:254364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9251054
    Focal_AT; Focal adhesion targeting region
  21. XM_024447204.1XP_024302972.1  focal adhesion kinase 1 isoform X7

    Conserved Domains (4) summary
    cd05056
    Location:466735
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9701099
    Focal_AT; Focal adhesion targeting region
  22. XM_024447201.1XP_024302969.1  focal adhesion kinase 1 isoform X3

    Conserved Domains (4) summary
    cd05056
    Location:472741
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87309
    B41; Band 4.1 homologues
    cd13190
    Location:305415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:9761105
    Focal_AT; Focal adhesion targeting region
  23. XM_017013657.2XP_016869146.1  focal adhesion kinase 1 isoform X11

    Related
    ENSP00000429129.1, ENST00000519419.5
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