Format

Send to:

Choose Destination

CRK CRK proto-oncogene, adaptor protein [ Homo sapiens (human) ]

Gene ID: 1398, updated on 18-Aug-2020

Summary

Official Symbol
CRKprovided by HGNC
Official Full Name
CRK proto-oncogene, adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:2362
See related
Ensembl:ENSG00000167193 MIM:164762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p38; CRKII
Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues See more
Orthologs

Genomic context

See CRK in Genome Data Viewer
Location:
17p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1420693..1456232, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1324647..1359561, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene myosin IC Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphorylated amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity TAS
Traceable Author Statement
more info
 
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cellular response to endothelin IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
cerebellar neuron development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
helper T cell diapedesis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
reelin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
response to cholecystokinin IEA
Inferred from Electronic Annotation
more info
 
response to hepatocyte growth factor IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to yeast IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IC
Inferred by Curator
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
adapter molecule crk
Names
proto-oncogene c-Crk
v-crk avian sarcoma virus CT10 oncogene homolog
v-crk sarcoma virus CT10 oncogene-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029008.1 RefSeqGene

    Range
    5019..40558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005206.5NP_005197.3  adapter molecule crk isoform b

    See identical proteins and their annotated locations for NP_005197.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (I) represents the shorter transcript and encodes the shorter isoform (b). Isoform b increases transformation activity due to the loss of a SH3 domain.
    Source sequence(s)
    AC032044, AK291060
    Consensus CDS
    CCDS45561.1
    UniProtKB/Swiss-Prot
    P46108
    UniProtKB/TrEMBL
    A0A0S2Z3K9
    Related
    ENSP00000381942.5, ENST00000398970.5
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. NM_016823.4NP_058431.2  adapter molecule crk isoform a

    See identical proteins and their annotated locations for NP_058431.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (II) includes an alternate segment, compared to variant I, resulting in a longer protein (isoform a) that has a distinct C-terminus and an additional SH3 domain, compared to isoform b. Isoform a is a negative modulator of transformation activity.
    Source sequence(s)
    AC032044, AU125411, BC008506
    Consensus CDS
    CCDS11002.1
    UniProtKB/Swiss-Prot
    P46108
    UniProtKB/TrEMBL
    A0A0S2Z3Q4, L7RT18
    Related
    ENSP00000300574.2, ENST00000300574.3
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    1420693..1456232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187613.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    362719..379185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center