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CRK CRK proto-oncogene, adaptor protein [ Homo sapiens (human) ]

Gene ID: 1398, updated on 11-Jun-2021

Summary

Official Symbol
CRKprovided by HGNC
Official Full Name
CRK proto-oncogene, adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:2362
See related
Ensembl:ENSG00000167193 MIM:164762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p38; CRKII
Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues See more
Orthologs
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Genomic context

See CRK in Genome Data Viewer
Location:
17p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1420693..1456232, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1323987..1359526, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene myosin IC Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphorylated amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of MAPKK activity TAS
Traceable Author Statement
more info
 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to endothelin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in helper T cell diapedesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reelin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of T cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in response to cholecystokinin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hepatocyte growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to yeast IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
adapter molecule crk
Names
proto-oncogene c-Crk
v-crk avian sarcoma virus CT10 oncogene homolog
v-crk sarcoma virus CT10 oncogene-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029008.1 RefSeqGene

    Range
    5019..40558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005206.5NP_005197.3  adapter molecule crk isoform b

    See identical proteins and their annotated locations for NP_005197.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (I) represents the shorter transcript and encodes the shorter isoform (b). Isoform b increases transformation activity due to the loss of a SH3 domain.
    Source sequence(s)
    AC032044, AK291060
    Consensus CDS
    CCDS45561.1
    UniProtKB/Swiss-Prot
    P46108
    UniProtKB/TrEMBL
    A0A0S2Z3K9
    Related
    ENSP00000381942.5, ENST00000398970.5
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. NM_016823.4NP_058431.2  adapter molecule crk isoform a

    See identical proteins and their annotated locations for NP_058431.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (II) includes an alternate segment, compared to variant I, resulting in a longer protein (isoform a) that has a distinct C-terminus and an additional SH3 domain, compared to isoform b. Isoform a is a negative modulator of transformation activity.
    Source sequence(s)
    AC032044, AU125411, BC008506
    Consensus CDS
    CCDS11002.1
    UniProtKB/Swiss-Prot
    P46108
    UniProtKB/TrEMBL
    A0A0S2Z3Q4, L7RT18
    Related
    ENSP00000300574.2, ENST00000300574.3
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    1420693..1456232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187613.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    362719..379185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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