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Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 12928, updated on 27-Nov-2024

Summary

Official Symbol
Crkprovided by MGI
Official Full Name
v-crk avian sarcoma virus CT10 oncogene homologprovided by MGI
Primary source
MGI:MGI:88508
See related
Ensembl:ENSMUSG00000017776 AllianceGenome:MGI:88508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III
Summary
This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.5), bladder adult (RPKM 18.1) and 28 other tissues See more
Orthologs
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Genomic context

See Crk in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75570020..75599254)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75679194..75708428)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3974 Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene STARR-positive B cell enhancer ABC_E3975 Neighboring gene myosin IC Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene double C2, beta Neighboring gene predicted gene 12339

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphorylated amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphorylated amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to endothelin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to endothelin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in enzyme-linked receptor protein signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in enzyme-linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in enzyme-linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in enzyme-linked receptor protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within helper T cell diapedesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell motility IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic specialization assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic specialization assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reelin-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of cell adhesion mediated by integrin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholecystokinin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cholecystokinin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hepatocyte growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hepatocyte growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to yeast IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adapter molecule crk
Names
CT-10 related kinase 3
avian sarcoma virus CT10 (v-crk) oncogene homolog
proto-oncogene c-crk
v-crk sarcoma virus CT10 oncogene-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277219.1NP_001264148.1  adapter molecule crk isoform 1

    See identical proteins and their annotated locations for NP_001264148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform 1 (also known as CrkI). Isoform 1 (CrkI) contains the SH2 domain and the N-terminal SH3 domain, both of which are proposed to be crucial for development.
    Source sequence(s)
    AK139089, AL591440
    Consensus CDS
    CCDS70241.1
    UniProtKB/TrEMBL
    Q8JZR2
    Related
    ENSMUSP00000104063.2, ENSMUST00000108425.8
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. NM_001277221.1NP_001264150.1  adapter molecule crk isoform 3

    See identical proteins and their annotated locations for NP_001264150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1 (CrkI). Isoform 3 does not have a complete SH2 domain and lacks an SH3 domain, both of which are found in isoform 1.
    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS70242.1
    UniProtKB/TrEMBL
    Q3TQV3
    Related
    ENSMUSP00000104064.2, ENSMUST00000108426.8
    Conserved Domains (1) summary
    cl15255
    Location:563
    SH2; Src homology 2 (SH2) domain
  3. NM_133656.5NP_598417.2  adapter molecule crk isoform 2

    See identical proteins and their annotated locations for NP_598417.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1, resulting in a longer protein (isoform 2, also known as CrkII) that has a distinct C-terminus and an additional SH3 domain, compared to isoform 1 (CrkI). Isoform 2 (CrkII) is proposed to have a negative regulatory role.
    Source sequence(s)
    AK028488, AL591440
    Consensus CDS
    CCDS25055.1
    UniProtKB/Swiss-Prot
    Q64010
    UniProtKB/TrEMBL
    Q5ND51, Q91VM1
    Related
    ENSMUSP00000017920.8, ENSMUST00000017920.14
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75570020..75599254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532125.3XP_006532188.1  adapter molecule crk isoform X2

    See identical proteins and their annotated locations for XP_006532188.1

    UniProtKB/TrEMBL
    Q3TTI0, Q5ND50
    Related
    ENSMUSP00000090803.4, ENSMUST00000093115.4
    Conserved Domains (2) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
  2. XM_006532124.4XP_006532187.1  adapter molecule crk isoform X1

    See identical proteins and their annotated locations for XP_006532187.1

    UniProtKB/TrEMBL
    Q920I1
    Related
    ENSMUSP00000116527.2, ENSMUST00000147718.2
    Conserved Domains (3) summary
    cd09926
    Location:5122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cl17036
    Location:237259
    SH3; Src Homology 3 domain superfamily