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CREM cAMP responsive element modulator [ Homo sapiens (human) ]

Gene ID: 1390, updated on 8-Dec-2018

Summary

Official Symbol
CREMprovided by HGNC
Official Full Name
cAMP responsive element modulatorprovided by HGNC
Primary source
HGNC:HGNC:2352
See related
Ensembl:ENSG00000095794 MIM:123812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICER; CREM-2; hCREM-2
Summary
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more
Orthologs

Genomic context

See CREM in Genome Data Viewer
Location:
10p11.21
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (35126830..35212958)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415769..35501886)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2635 Neighboring gene cullin 2 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene cyclin Y

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
    Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17881, MGC41893, MGC111110

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cAMP-responsive element modulator
Names
CREM 2alpha-b protein
CREM 2beta-a protein
cAMP response element modulator
inducible cAMP early repressor ICER

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029065.1 RefSeqGene

    Range
    4969..91086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267562.1NP_001254491.1  cAMP-responsive element modulator isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG573680, BI459432, DA756152
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd14690
    Location:122176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001267563.1NP_001254492.1  cAMP-responsive element modulator isoform 24

    See identical proteins and their annotated locations for NP_001254492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AL157783, BC041810, CB996061, DA756152
    Conserved Domains (1) summary
    cd14690
    Location:59113
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001267564.1NP_001254493.1  cAMP-responsive element modulator isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BU193626, CD358637
    Consensus CDS
    CCDS58074.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000379225.3, ENST00000395887.7
    Conserved Domains (2) summary
    cd14690
    Location:225279
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:3875
    pKID; pKID domain
  4. NM_001267565.1NP_001254494.1  cAMP-responsive element modulator isoform 26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BU193626, BU570307, CK300763
    Conserved Domains (2) summary
    pfam02173
    Location:6683
    pKID; pKID domain
    pfam13900
    Location:3267
    GVQW; Putative domain of unknown function
  5. NM_001267566.1NP_001254495.1  cAMP-responsive element modulator isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BP370901, BU570307, CK300763
    Conserved Domains (1) summary
    pfam02173
    Location:1350
    pKID; pKID domain
  6. NM_001267567.1NP_001254496.1  cAMP-responsive element modulator isoform 28

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, BC041810, BG720999, BP370901
    Consensus CDS
    CCDS58075.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000418336.1, ENST00000463314.5
    Conserved Domains (1) summary
    cd14690
    Location:81135
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  7. NM_001267568.1NP_001254497.1  cAMP-responsive element modulator isoform 29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD639591, CD640977, D14826
  8. NM_001267569.1NP_001254498.1  cAMP-responsive element modulator isoform 30

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD640977, D14826
  9. NM_001267570.1NP_001254499.1  cAMP-responsive element modulator isoform 31

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK289379, AL117336, BC041810, CD640465
    Consensus CDS
    CCDS58076.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000419810.1, ENST00000468236.5
    Conserved Domains (1) summary
    cd14690
    Location:68122
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  10. NM_001352445.1NP_001339374.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AK289379, AL117336, AL157783, BC041810, DA823429, HY169431
    Consensus CDS
    CCDS53522.1
    Related
    ENSP00000344365.5, ENST00000344351.5
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  11. NM_001352446.1NP_001339375.1  cAMP-responsive element modulator isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783, BC041810, CD686814, D79104, DA823429, DT220562
    Consensus CDS
    CCDS53523.1
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  12. NM_001352465.1NP_001339394.1  cAMP-responsive element modulator isoform 33

    Status: REVIEWED

    Source sequence(s)
    AA453346, AL117336, AL157783, BC041810, DA756152
    Consensus CDS
    CCDS53523.1
    Related
    ENSP00000419018.1, ENST00000474362.5
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  13. NM_001352466.1NP_001339395.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783, BC041810, CN367927, DA756152
    Consensus CDS
    CCDS53522.1
    Related
    ENSP00000420437.1, ENST00000460270.5
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  14. NM_001352467.1NP_001339396.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783, BC041810, DA756152, DR760671
    Consensus CDS
    CCDS53522.1
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  15. NM_001881.3NP_001872.3  cAMP-responsive element modulator isoform 2

    See identical proteins and their annotated locations for NP_001872.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017117, BC066342, DA756152
    Consensus CDS
    CCDS7184.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363858.3, ENST00000374726.7
    Conserved Domains (1) summary
    pfam02173
    Location:5289
    pKID; pKID domain
  16. NM_181571.2NP_853549.1  cAMP-responsive element modulator isoform 1

    See identical proteins and their annotated locations for NP_853549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, BI561543
    Consensus CDS
    CCDS7180.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000265372.5, ENST00000345491.7
    Conserved Domains (2) summary
    cd14690
    Location:243297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  17. NM_182717.1NP_874386.1  cAMP-responsive element modulator isoform 4

    See identical proteins and their annotated locations for NP_874386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS7187.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000420681.1, ENST00000473940.5
    Conserved Domains (1) summary
    cd14690
    Location:64118
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  18. NM_182718.1NP_874387.1  cAMP-responsive element modulator isoform 5

    See identical proteins and their annotated locations for NP_874387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53519.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417460.1, ENST00000488328.5
    Conserved Domains (1) summary
    cd14690
    Location:52106
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  19. NM_182719.1NP_874388.1  cAMP-responsive element modulator isoform 6

    See identical proteins and their annotated locations for NP_874388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS53517.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417807.1, ENST00000487763.5
    Conserved Domains (1) summary
    cd14690
    Location:64118
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  20. NM_182720.1NP_874389.1  cAMP-responsive element modulator isoform 7

    See identical proteins and their annotated locations for NP_874389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53518.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000349387.5, ENST00000356917.9
    Conserved Domains (1) summary
    cd14690
    Location:52106
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  21. NM_182721.1NP_874390.1  cAMP-responsive element modulator isoform 8

    See identical proteins and their annotated locations for NP_874390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS7188.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417562.1, ENST00000474931.5
    Conserved Domains (1) summary
    cd14690
    Location:56110
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  22. NM_182723.1NP_874392.1  cAMP-responsive element modulator isoform 10

    See identical proteins and their annotated locations for NP_874392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CD686814
    Consensus CDS
    CCDS53521.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000419075.1, ENST00000488741.5
    Conserved Domains (1) summary
    cd14690
    Location:46100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  23. NM_182724.1NP_874393.1  cAMP-responsive element modulator isoform 11

    See identical proteins and their annotated locations for NP_874393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS53520.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417327.1, ENST00000490511.1
    Conserved Domains (1) summary
    cd14690
    Location:56110
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  24. NM_182769.2NP_877570.1  cAMP-responsive element modulator isoform 13

    See identical proteins and their annotated locations for NP_877570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    Consensus CDS
    CCDS7186.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000341875.3, ENST00000342105.7
    Conserved Domains (2) summary
    cd14690
    Location:188242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:1350
    pKID; pKID domain
  25. NM_182770.2NP_877571.1  cAMP-responsive element modulator isoform 14

    See identical proteins and their annotated locations for NP_877571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:125179
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:1350
    pKID; pKID domain
  26. NM_182771.1NP_877572.1  cAMP-responsive element modulator isoform 15

    See identical proteins and their annotated locations for NP_877572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    Consensus CDS
    CCDS7185.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000354593.4, ENST00000361599.8
    Conserved Domains (2) summary
    cd14690
    Location:213267
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:3875
    pKID; pKID domain
  27. NM_182772.1NP_877573.1  cAMP-responsive element modulator isoform 16

    See identical proteins and their annotated locations for NP_877573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417165.1, ENST00000484283.5
    Conserved Domains (2) summary
    cd14690
    Location:150204
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:3875
    pKID; pKID domain
  28. NM_183011.1NP_898829.1  cAMP-responsive element modulator isoform 21

    See identical proteins and their annotated locations for NP_898829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825
    Consensus CDS
    CCDS7181.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000337138.4, ENST00000337656.8
    Conserved Domains (2) summary
    cd14690
    Location:243297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  29. NM_183012.1NP_898830.1  cAMP-responsive element modulator isoform 20

    See identical proteins and their annotated locations for NP_898830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825
    Consensus CDS
    CCDS31181.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363866.3, ENST00000374734.7
    Conserved Domains (2) summary
    cd14690
    Location:180234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  30. NM_183013.2NP_898831.1  cAMP-responsive element modulator isoform 19

    See identical proteins and their annotated locations for NP_898831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, DA756152
    Consensus CDS
    CCDS7182.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000346804.3, ENST00000354759.7
    Conserved Domains (2) summary
    cd14690
    Location:192246
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  31. NM_183060.2NP_898883.1  cAMP-responsive element modulator isoform 22

    See identical proteins and their annotated locations for NP_898883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, AV707433, BC041810, BI561543
    Consensus CDS
    CCDS7183.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363860.3, ENST00000374728.7
    Conserved Domains (2) summary
    cd14690
    Location:164218
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5289
    pKID; pKID domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    35126830..35212958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015734.2XP_016871223.1  cAMP-responsive element modulator isoform X28

  2. XM_017015724.1XP_016871213.1  cAMP-responsive element modulator isoform X21

    Conserved Domains (1) summary
    cd14690
    Location:134188
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  3. XM_017015728.1XP_016871217.1  cAMP-responsive element modulator isoform X24

  4. XM_017015737.2XP_016871226.1  cAMP-responsive element modulator isoform X31

    Conserved Domains (1) summary
    cd14690
    Location:59113
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  5. XM_017015727.1XP_016871216.1  cAMP-responsive element modulator isoform X23

    Conserved Domains (1) summary
    cd14690
    Location:122176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  6. XM_017015729.1XP_016871218.1  cAMP-responsive element modulator isoform X24

  7. XM_024447820.1XP_024303588.1  cAMP-responsive element modulator isoform X5

    Conserved Domains (2) summary
    cd14690
    Location:239293
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5289
    pKID; pKID domain
  8. XM_017015719.2XP_016871208.1  cAMP-responsive element modulator isoform X10

  9. XM_017015717.2XP_016871206.1  cAMP-responsive element modulator isoform X7

  10. XM_017015716.2XP_016871205.1  cAMP-responsive element modulator isoform X6

  11. XM_024447822.1XP_024303590.1  cAMP-responsive element modulator isoform X18

    Conserved Domains (2) summary
    cd14690
    Location:176230
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5289
    pKID; pKID domain
  12. XM_017015721.2XP_016871210.1  cAMP-responsive element modulator isoform X16

    Related
    ENSP00000419684.2, ENST00000463960.5
  13. XM_017015723.2XP_016871212.1  cAMP-responsive element modulator isoform X20

    Related
    ENSP00000363853.3, ENST00000374721.7
  14. XM_017015722.2XP_016871211.1  cAMP-responsive element modulator isoform X19

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:164218
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5289
    pKID; pKID domain
  15. XM_017015726.2XP_016871215.1  cAMP-responsive element modulator isoform X22

  16. XM_006717379.3XP_006717442.1  cAMP-responsive element modulator isoform X4

    See identical proteins and their annotated locations for XP_006717442.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:243297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  17. XM_006717378.4XP_006717441.1  cAMP-responsive element modulator isoform X3

    See identical proteins and their annotated locations for XP_006717441.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:243297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  18. XM_017015736.1XP_016871225.1  cAMP-responsive element modulator isoform X30

  19. XM_017015733.1XP_016871222.1  cAMP-responsive element modulator isoform X27

  20. XM_024447824.1XP_024303592.1  cAMP-responsive element modulator isoform X32

    Conserved Domains (2) summary
    cd14690
    Location:304358
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:117154
    pKID; pKID domain
  21. XM_006717387.3XP_006717450.1  cAMP-responsive element modulator isoform X2

    Conserved Domains (2) summary
    cd14690
    Location:255309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  22. XM_011519324.2XP_011517626.1  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_011517626.1

    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000420511.1, ENST00000479070.5
    Conserved Domains (2) summary
    cd14690
    Location:255309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  23. XM_017015720.1XP_016871209.1  cAMP-responsive element modulator isoform X11

  24. XM_006717383.3XP_006717446.1  cAMP-responsive element modulator isoform X15

    See identical proteins and their annotated locations for XP_006717446.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:180234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  25. XM_006717382.3XP_006717445.1  cAMP-responsive element modulator isoform X14

    See identical proteins and their annotated locations for XP_006717445.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:180234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  26. XM_024447823.1XP_024303591.1  cAMP-responsive element modulator isoform X25

    Conserved Domains (1) summary
    cd14690
    Location:93147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  27. XM_017015718.1XP_016871207.1  cAMP-responsive element modulator isoform X8

  28. XM_017015725.1XP_016871214.1  cAMP-responsive element modulator isoform X21

    Conserved Domains (1) summary
    cd14690
    Location:134188
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  29. XM_017015735.1XP_016871224.1  cAMP-responsive element modulator isoform X29

  30. XM_017015731.1XP_016871220.1  cAMP-responsive element modulator isoform X25

    Conserved Domains (1) summary
    cd14690
    Location:93147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  31. XM_017015732.1XP_016871221.1  cAMP-responsive element modulator isoform X26

    Conserved Domains (1) summary
    cd14690
    Location:93147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  32. XM_011519325.3XP_011517627.1  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_011517627.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    cd14690
    Location:255309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68105
    pKID; pKID domain
  33. XM_011519327.3XP_011517629.1  cAMP-responsive element modulator isoform X5

    See identical proteins and their annotated locations for XP_011517629.1

    Conserved Domains (2) summary
    cd14690
    Location:239293
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5289
    pKID; pKID domain
  34. XM_011519331.2XP_011517633.1  cAMP-responsive element modulator isoform X12

    Conserved Domains (1) summary
    cd14690
    Location:188242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  35. XM_011519335.2XP_011517637.1  cAMP-responsive element modulator isoform X25

    See identical proteins and their annotated locations for XP_011517637.1

    Conserved Domains (1) summary
    cd14690
    Location:93147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  36. XM_011519330.2XP_011517632.1  cAMP-responsive element modulator isoform X9

    Conserved Domains (2) summary
    cd14690
    Location:200254
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:1350
    pKID; pKID domain
  37. XM_011519332.2XP_011517634.1  cAMP-responsive element modulator isoform X17

    Conserved Domains (1) summary
    cd14690
    Location:176230
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  38. XM_011519333.1XP_011517635.1  cAMP-responsive element modulator isoform X21

    Conserved Domains (1) summary
    cd14690
    Location:134188
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  39. XM_024447821.1XP_024303589.1  cAMP-responsive element modulator isoform X13

    Conserved Domains (2) summary
    cd14690
    Location:188242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:1350
    pKID; pKID domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182722.1: Suppressed sequence

    Description
    NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_182725.1: Suppressed sequence

    Description
    NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  3. NM_182850.2: Suppressed sequence

    Description
    NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  4. NM_182853.2: Suppressed sequence

    Description
    NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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