U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dlg4 discs large MAGUK scaffold protein 4 [ Mus musculus (house mouse) ]

Gene ID: 13385, updated on 17-Feb-2024

Summary

Official Symbol
Dlg4provided by MGI
Official Full Name
discs large MAGUK scaffold protein 4provided by MGI
Primary source
MGI:MGI:1277959
See related
Ensembl:ENSMUSG00000020886 AllianceGenome:MGI:1277959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlgh4; PSD95; SAP90; PSD-95; SAP90A
Summary
Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density membrane; and synaptic vesicle. Is extrinsic component of cytoplasmic side of plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 161.9), frontal lobe adult (RPKM 143.5) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dlg4 in Genome Data Viewer
Location:
11 B3; 11 42.96 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69908029..69938107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70017203..70045535)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene STARR-positive B cell enhancer ABC_E11483 Neighboring gene STARR-positive B cell enhancer ABC_E1421 Neighboring gene STARR-positive B cell enhancer ABC_E2358 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene predicted gene, 32946

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (14)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables P2Y1 nucleotide receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-1 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables neurexin family protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables neuroligin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in AMPA glutamate receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in locomotory behavior NAS
Non-traceable Author Statement
more info
PubMed 
involved_in locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in postsynaptic neurotransmitter receptor diffusion trapping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to cocaine NAS
Non-traceable Author Statement
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cerebellar mossy fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic branch ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disks large homolog 4
Names
PSD-95 alpha 2b
PSD-95 beta
SAP-90
discs large homolog 4
discs, large homolog 4
postsynaptic density protein 95
synapse-associated protein 90

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109752.1NP_001103222.1  disks large homolog 4 isoform 2

    See identical proteins and their annotated locations for NP_001103222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 6.
    Source sequence(s)
    BC014807, BQ959940, CA320223
    Consensus CDS
    CCDS48829.1
    UniProtKB/TrEMBL
    G3UZL5
    Related
    ENSMUSP00000156345.2, ENSMUST00000231415.2
    Conserved Domains (7) summary
    cd12030
    Location:427492
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:541707
    GuKc; Guanylate kinase homologues
    smart00228
    Location:307391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:62146
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:530708
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242309
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1061
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  2. NM_001370671.1NP_001357600.1  disks large homolog 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596185
    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:435500
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:315399
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00625
    Location:538716
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:250317
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam00595
    Location:70154
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam10608
    Location:1969
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  3. NM_001370672.1NP_001357601.1  disks large homolog 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS88179.1
    UniProtKB/TrEMBL
    A0A338P6E5, G3UZL5
    Conserved Domains (5) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  4. NM_001370674.1NP_001357603.1  disks large homolog 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596185
    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:406471
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:286370
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00625
    Location:509687
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:221288
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam00595
    Location:41125
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam10608
    Location:1040
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  5. NM_001370675.1NP_001357604.1  disks large homolog 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6)
    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS88178.1
    UniProtKB/TrEMBL
    A0A338P6I6, G3UZL5
    Related
    ENSMUSP00000155973.2, ENSMUST00000231506.2
    Conserved Domains (7) summary
    cd12030
    Location:470535
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:350434
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00625
    Location:573751
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:285352
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam00595
    Location:105189
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam10608
    Location:54104
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:2647
    L27; L27 domain
  6. NM_007864.3NP_031890.1  disks large homolog 4 isoform 1

    See identical proteins and their annotated locations for NP_031890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 6.
    Source sequence(s)
    BC014807, BI738861, BQ959940, CA320223
    Consensus CDS
    CCDS36202.1
    UniProtKB/Swiss-Prot
    Q5NCV5, Q5NCV6, Q5NCV7, Q62108, Q91WJ1
    UniProtKB/TrEMBL
    G3UZL5
    Related
    ENSMUSP00000104229.3, ENSMUST00000108588.9
    Conserved Domains (7) summary
    cd12030
    Location:430495
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:544710
    GuKc; Guanylate kinase homologues
    smart00228
    Location:310394
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:65149
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:533711
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1064
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69908029..69938107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156285.1XP_036012178.1  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:463528
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:343427
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:98182
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:566744
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1097
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  2. XM_006532144.3XP_006532207.1  disks large homolog 4 isoform X2

    See identical proteins and their annotated locations for XP_006532207.1

    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:460525
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:340424
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:95179
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:563741
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:275342
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1094
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  3. XM_006532148.3XP_006532211.1  disks large homolog 4 isoform X4

    See identical proteins and their annotated locations for XP_006532211.1

    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:408473
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:288372
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:43127
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:511689
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:223290
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1142
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  4. XM_006532150.3XP_006532213.1  disks large homolog 4 isoform X5

    See identical proteins and their annotated locations for XP_006532213.1

    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:405470
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:285369
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:40124
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:508686
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:220287
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1139
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  5. XM_036156286.1XP_036012179.1  disks large homolog 4 isoform X6

    UniProtKB/TrEMBL
    A0A338P6E5, G3UZL5
    Related
    ENSMUSP00000018700.8, ENSMUST00000018700.14
    Conserved Domains (5) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  6. XM_006532147.5XP_006532210.3  disks large homolog 4 isoform X3

    UniProtKB/TrEMBL
    G3UZL5
    Conserved Domains (6) summary
    cd12030
    Location:409474
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:289373
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:44127
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:512690
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:224291
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:843
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

  1. XR_001779872.2 RNA Sequence