DLG4 discs large MAGUK scaffold protein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DLG4provided by HGNC
Official Full Name: discs large MAGUK scaffold protein 4provided by HGNC
Primary source: HGNC:HGNC:2903
See related: Ensembl:ENSG00000132535 MIM:602887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRD62; PSD95; SAP90; SAP-90
Summary: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in brain (RPKM 34.6), testis (RPKM 6.2) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	17	NC_000017.11 (7187187..7220050, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7090506..7123369, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DLG4-related synaptopathy: a new rare brain disorder.
Title: DLG4-related synaptopathy: a new rare brain disorder.
Association Between PSD95 Gene 3'UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population.
Title: Association Between PSD95 Gene 3'UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population.
Dlg4 and Vamp2 are involved in comorbid epilepsy and attention-deficit hyperactivity disorder: A microarray data study.
Title: Dlg4 and Vamp2 are involved in comorbid epilepsy and attention-deficit hyperactivity disorder: A microarray data study.
Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95.
Title: Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95.
Ligand-dependent intra- and interdomain motions in the PDZ12 tandem regulate binding interfaces in postsynaptic density protein-95.
Title: Ligand-dependent intra- and interdomain motions in the PDZ12 tandem regulate binding interfaces in postsynaptic density protein-95.
The PSD-95 GK domain binds to Gnb5, and this interaction is triggered by CRIPT-derived PDZ3 ligands binding to the third PDZ domain of PSD-95, unraveling a hierarchical binding mechanism of PSD-95 complex formation.
Title: Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
both unphosphorylated FMRP and its phosphomimic FMRP S500D bind to the PSD-95 mRNA G-quadruplexes with high affinity, whereas only FMRP S500D binds to miR-125a
Title: FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA.
the role of DLG4 as a novel post-synaptic-associated gene involved in syndromic intellectual disability associated with Marfanoid habitus, is reported.
Title: Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features.
Crystallographic structures of the following have been solved: a truncated form of the third PDZ domain of the neuronal postsynaptic density protein 95 from which alpha3 has been removed, D332P and D332G variants of the protein, and a new crystal form of this domain showing the binding of Asp332 to the carboxylate-binding site of a symmetry-related molecule.
Title: Conformational changes in the third PDZ domain of the neuronal postsynaptic density protein 95.
Here we report an evaluation of the effect of the truncation of this additional helix on the folding and unfolding kinetics of PSD-95 (PDZ3). Fluorescent variants of full length and truncated PDZ3 were produced and stopped-flow fluorescence measurements were made under different experimental conditions (pH, ionic strength and temperature) to investigate the folding kinetics of the respective variant.
Title: Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Discovery and refinement of loci associated with lipid levels. GeneReviews: Not available
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. GeneReviews: Not available
Intellectual developmental disorder 62 MedGen: C5394083 OMIM: 618793 GeneReviews: Not available	Compare labs
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induced-neurotoxicity involves upregulation of NR2B and downregulation of PSD-95 expressions in neuron cells	PubMed
	env	HIV-1 gp120-induced synapse loss significantly decreases levels of PSD-95 protein by the ubiquitin-proteasome pathway in the puncta	PubMed
Tat	tat	HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface	PubMed
	tat	HIV-1 Tat decreases the scaffolding protein postsynaptic density 95 (PSD95) in synapses via the low-density lipoprotein receptor-related protein (LRP); Tat decreases PSD95 in a concentration-dependent manner	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the DLG4 gene: The DLG4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
Orthologs from Annotation Pipeline: 304 organisms have orthologs with human gene DLG4
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables P2Y1 nucleotide receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetylcholine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-1 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-2 adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables immunoglobulin binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein C-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of postsynaptic density	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in AMPA glutamate receptor clustering	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to potassium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in learning	TAS Traceable Author Statement more info	PubMed
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in receptor localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of grooming behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in anchored component of postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cerebellar mossy fiber	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in juxtaparanode region of axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuron projection terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron spine	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: disks large homolog 4

Names: Tax interaction protein 15; discs large homolog 4; post-synaptic density protein 95; synapse-associated protein 90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008391.2 RefSeqGene

Range

5001..35161

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128827.4 → NP_001122299.1 disks large homolog 4 isoform 2

See identical proteins and their annotated locations for NP_001122299.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks a 3 amino acid internal segment when compared to isoform 1.

Source sequence(s)

AA954439, AC120057, AK307804, AK308533, BC030203, DC336011

Consensus CDS

CCDS45600.1

UniProtKB/Swiss-Prot

P78352

Related

ENSP00000307471.6, ENST00000302955.11

Conserved Domains (6) summary

cd12030
Location:427 → 492

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:307 → 391

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:62 → 146

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:530 → 708

Guanylate_kin; Guanylate kinase

pfam10600
Location:242 → 309

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 61

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001321074.1 → NP_001308003.1 disks large homolog 4 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC120057, AI571947, BC030203, BC136553, DB064366

UniProtKB/TrEMBL

B9EGL1

Related

ENSP00000382428.3, ENST00000399510.8

Conserved Domains (7) summary

cd12030
Location:470 → 535

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:350 → 434

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:105 → 189

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:573 → 751

Guanylate_kin; Guanylate kinase

pfam10600
Location:285 → 352

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:54 → 104

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl02672
Location:26 → 49

L27; L27 domain
NM_001321075.3 → NP_001308004.1 disks large homolog 4 isoform 4

Status: REVIEWED

Source sequence(s)

AC120057, AK293835, BC030203, BG059570, DC336011

Consensus CDS

CCDS82050.1

UniProtKB/Swiss-Prot

P78352

Related

ENSP00000382425.2, ENST00000399506.9

Conserved Domains (6) summary

cd12030
Location:430 → 495

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:310 → 394

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:65 → 149

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:533 → 711

Guanylate_kin; Guanylate kinase

pfam10600
Location:245 → 312

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 64

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001321076.3 → NP_001308005.1 disks large homolog 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC120057, AI571947, AK299801, BC030203, BP213421

UniProtKB/TrEMBL

B7Z647

Related

ENSP00000497647.1, ENST00000649520.1

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
NM_001321077.3 → NP_001308006.1 disks large homolog 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC120057, AI571947, AK297346, AK299801, BC030203, BP213421

UniProtKB/TrEMBL

B7Z4H2, B7Z647

Related

ENSP00000497879.1, ENST00000649186.1

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
NM_001365.4 → NP_001356.1 disks large homolog 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_001356.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC120057, AI571947, AK299801, BC030203, BC136553, DB064366, U83192

Consensus CDS

CCDS45599.1

UniProtKB/Swiss-Prot

P78352

UniProtKB/TrEMBL

B7Z647, B9EGL1

Related

ENSP00000497806.3, ENST00000648172.8

Conserved Domains (7) summary

cd12030
Location:473 → 538

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:353 → 437

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:108 → 192

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:576 → 754

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 355

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:54 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl02672
Location:26 → 49

L27; L27 domain
NM_001369566.3 → NP_001356495.1 disks large homolog 4 isoform 6

Status: REVIEWED

Source sequence(s)

AC120057, AK308533

Related

ENSP00000497011.1, ENST00000649971.1

Conserved Domains (6) summary

cd12030
Location:403 → 468

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:283 → 367

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00625
Location:506 → 684

Guanylate_kin; Guanylate kinase

pfam10600
Location:218 → 285

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam00595
Location:38 → 122

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam10608
Location:8 → 37

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

NR_135527.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC120057, AI571947, AK296357, BC030203, BC136553, DB064366

Related

ENST00000491753.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p13 Primary Assembly

Range

7187187..7220050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011523699.2 → XP_011522001.1 disks large homolog 4 isoform X1

See identical proteins and their annotated locations for XP_011522001.1

Conserved Domains (7) summary

cd12030
Location:503 → 568

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:383 → 467

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:138 → 222

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:606 → 784

Guanylate_kin; Guanylate kinase

pfam10600
Location:318 → 385

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:54 → 137

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl02672
Location:26 → 49

L27; L27 domain
XM_005256491.1 → XP_005256548.1 disks large homolog 4 isoform X2

See identical proteins and their annotated locations for XP_005256548.1

Conserved Domains (6) summary

cd12030
Location:460 → 525

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:340 → 424

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:95 → 179

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:563 → 741

Guanylate_kin; Guanylate kinase

pfam10600
Location:275 → 342

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 94

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017024289.2 → XP_016879778.1 disks large homolog 4 isoform X5

Conserved Domains (6) summary

cd12030
Location:405 → 470

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:285 → 369

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:40 → 124

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:508 → 686

Guanylate_kin; Guanylate kinase

pfam10600
Location:220 → 287

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:7 → 39

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017024288.2 → XP_016879777.1 disks large homolog 4 isoform X4

Conserved Domains (6) summary

cd12030
Location:408 → 473

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:288 → 372

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:43 → 127

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:511 → 689

Guanylate_kin; Guanylate kinase

pfam10600
Location:223 → 290

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:7 → 42

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_024450629.1 → XP_024306397.1 disks large homolog 4 isoform X3

Related

ENSP00000497546.1, ENST00000648896.1

Conserved Domains (6) summary

cd12030
Location:425 → 490

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:305 → 389

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:60 → 144

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:528 → 706

Guanylate_kin; Guanylate kinase

pfam10600
Location:240 → 307

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:6 → 59

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_011523702.1 → XP_011522004.1 disks large homolog 4 isoform X7

See identical proteins and their annotated locations for XP_011522004.1

UniProtKB/TrEMBL

B7Z647

Related

ENSP00000497553.1, ENST00000650120.1

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors