Conserved Protein Domain Family
MAGUK_N_PEST
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pfam10608: MAGUK_N_PEST (this model, PSSM-Id:337803 is obsolete and has been replaced by 431391)
Polyubiquitination (PEST) N-terminal domain of MAGUK
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerization of the whole protein.
Links
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Statistics
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PSSM-Id: 337803
Aligned: 21 rows
Threshold Bit Score: 80.482
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q62936        53 GYSSQtlpSQAgA----TPTPRTKAKLIPT--------------GRDvg-pvPP-------------------------- 87   Norway rat
OCT65730      44 GYNSQ---TLP-SqpavTPTARGKSKLMPA--------------TREnl--tPTl------------------------- 78   African clawed...
XP_005997203  96 KHKCQ---DED-S----LISDIRLPKYAES--------------AQSfs-qdPEl------------------------- 127  coelacanth
XP_009237971 107 KYRYQ---DED-T----PPQEHISPQITNE--------------VIG-----PEl------------------------- 134  Sumatran orang...
XP_007505979  59 KYRYQ---DED-T----PPQEPSSPTITNE--------------VTG-----PEl------------------------- 86   gray short-tai...
XP_011357975  11 KYRYQ---DED-T----PPLEHSPAHLPNQ--------------VNA-----PEl------------------------- 38   large flying fox
XP_006806842  10 wYHYQ---EDD-S----PLLDHGFPQLSSG--------------LRA-----PEl------------------------- 37   Neolamprologus...
XP_012012597  36 KYRYQ---DED------APHDHSLPRLTHE--------------VRG-----PEl------------------------- 62   mouflon
KKF30210     355 KYRYQ---EEDgA----SPGAPTLHQHPCHqhpmgvarelrdrgTLG-----REgreggtwrreggstgtterererslg 422  large yellow c...
XP_015715462  42 GYGSQtlpAPGgA----APAARGKAKLGPP--------------ARDaaalkPP-------------------------- 77   Japanese quail

Q62936        88 -----------------KPVPGKNTPKLNGSgpswwpECTCTNRDwy--------------------------------- 117  Norway rat
OCT65730      79 -----------------KAPPKSATPKMNGNsqnwwpECTCTNRDwy--------------------------------- 108  African clawed...
XP_005997203 128 -----------------VTVTSRSTELKESI------YSVVSHSHial-------------------------------- 152  coelacanth
XP_009237971 135 -----------------VHVSEKNLSEIENV------HGFVSHSHispikpteavlpcpptapv--------ipalpvpa 183  Sumatran orang...
XP_007505979  87 -----------------VHISEKNLSEIENV------HGFVSHSHispvksteaappsppivpv--------vpvlpvsa 135  gray short-tai...
XP_011357975  39 -----------------VHVAERNLSHLEAV------HGVVGHTHlsp-------------------------------- 63   large flying fox
XP_006806842  38 -----------------VHVSQKNLSEIENV------HGYVSHSHisp-------------------------------- 62   Neolamprologus...
XP_012012597  63 -----------------VHVSEKNLSQIENV------HGYVLQSHisp-------------------------------- 87   mouflon
KKF30210     423 rdgslsrhpgdlrgaelVQVAERQLSQIQHV------HGYITHTHitpaqvespevpfddevwphpegerlnevppppfs 496  large yellow c...
XP_015715462  78 -----------------PPPPGKSAPKVNGSgpgwwpECTCSSRDwy--------------------------------- 107  Japanese quail

Q62936       118 ---------eqASPAPLLVNPEALEPSLSVNGSDGMFKYE 148  Norway rat
OCT65730     109 ---------eqAGAAPLLVNTDCLDPSSSVNGSDTLYKYE 139  African clawed frog
XP_005997203 153 ---------pkAKPPPIIVNTDSLEHDPYVNGTDGVYKYE 183  coelacanth
XP_009237971 184 estvilpaipqANPPPVLVNTDSLETPTYVNGTDADYEYE 223  Sumatran orangutan
XP_007505979 136 entvsppttpqANPPPVLVNTDNLEPSAYVNGTDADYEYE 175  gray short-tailed opossum
XP_011357975  64 ---------lkANSPPVIVNTDTLEAPGYVNGTEGEMEYE 94   large flying fox
XP_006806842  63 ---------lkANPAPMIINTDTLESLPYVNGTEIEYEFE 93   Neolamprologus brichardi
XP_012012597  88 ---------lkASPAPIIVNTDTLDTIPYVNGTEIEYEFE 118  mouflon
KKF30210     497 slysqshayyqANPPPVVVNTDTVDTPPYVNGTEADYEYE 536  large yellow croaker
XP_015715462 108 ---------eqANPAPIIVNTDSLEQGLSVNGSDGMFKYE 138  Japanese quail
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