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Dapk3 death-associated protein kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 13144, updated on 5-Jan-2023

Summary

Official Symbol
Dapk3provided by MGI
Official Full Name
death-associated protein kinase 3provided by MGI
Primary source
MGI:MGI:1203520
See related
Ensembl:ENSMUSG00000034974 AllianceGenome:MGI:1203520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dlk; ZIPK
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including cellular response to interferon-gamma; regulation of cell shape; and regulation of myosin II filament organization. Acts upstream of or within apoptotic signaling pathway. Located in PML body. Is expressed in heart; mammary gland epithelium; and notochord. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 67.6), duodenum adult (RPKM 59.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dapk3 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81018821..81029031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81182987..81193197)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2 Neighboring gene ataxia, cerebellar, Cayman type

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to type II interferon IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myosin II filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
death-associated protein kinase 3
Names
DAP kinase 3
DAP-like kinase
MYPT1 kinase
ZIP-kinase
death-associated kinase 3
NP_001177402.1
NP_001177403.2
NP_031854.1
XP_006513257.1
XP_006513258.1
XP_030100726.1
XP_036011469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190473.1NP_001177402.1  death-associated protein kinase 3 isoform b

    See identical proteins and their annotated locations for NP_001177402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24045.1
    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    A0A6P5QA61, Q05A21
    Related
    ENSMUSP00000035962.7, ENSMUST00000047665.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
  2. NM_001190474.1NP_001177403.2  death-associated protein kinase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC155932
    UniProtKB/TrEMBL
    A0A8C6I065
    Conserved Domains (2) summary
    smart00220
    Location:30292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14105
    Location:24292
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
  3. NM_007828.2NP_031854.1  death-associated protein kinase 3 isoform b

    See identical proteins and their annotated locations for NP_031854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24045.1
    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    A0A6P5QA61, Q05A21
    Related
    ENSMUSP00000151577.2, ENSMUST00000219850.2
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81018821..81029031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513194.2XP_006513257.1  death-associated protein kinase 3 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:24285
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030244866.1XP_030100726.1  death-associated protein kinase 3 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:7268
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006513195.4XP_006513258.1  death-associated protein kinase 3 isoform X2

    See identical proteins and their annotated locations for XP_006513258.1

    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    A0A6P5QA61, Q05A21
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
  4. XM_036155576.1XP_036011469.1  death-associated protein kinase 3 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:7268
    PKc_like; Protein Kinases, catalytic domain