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DAPK3 death associated protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 1613, updated on 7-Dec-2018

Summary

Official Symbol
DAPK3provided by HGNC
Official Full Name
death associated protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:2676
See related
Ensembl:ENSG00000167657 MIM:603289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK; ZIP; ZIPK
Summary
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 16.5), prostate (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See DAPK3 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (3958453..3971123, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3958451..3971097, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATCAY, caytaxin Neighboring gene RNA, 7SL, cytoplasmic 202, pseudogene Neighboring gene nicotinamide riboside kinase 2 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene protein inhibitor of activated STAT 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
NHGRI GWA Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Bladder Cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, organism-specific biosystem (from KEGG)
    Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, conserved biosystem (from KEGG)
    Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • Ligand-independent caspase activation via DCC, organism-specific biosystem (from REACTOME)
    Ligand-independent caspase activation via DCC, organism-specific biosystemIn the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
Rho GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP response element binding protein binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton reorganization TAS
Traceable Author Statement
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of cell motility TAS
Traceable Author Statement
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 
regulation of myosin II filament organization IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle contraction TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
actin filament IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
death-associated protein kinase 3
Names
DAP kinase 3
DAP-like kinase
MYPT1 kinase
ZIP-kinase
zipper-interacting protein kinase
NP_001339.1
XP_005259565.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348.3NP_001339.1  death-associated protein kinase 3

    See identical proteins and their annotated locations for NP_001339.1

    Status: REVIEWED

    Source sequence(s)
    AI654829, AK027590, AK074799, DA748997, HY104892
    Consensus CDS
    CCDS12116.1
    UniProtKB/Swiss-Prot
    O43293
    UniProtKB/TrEMBL
    B3KNJ3
    Related
    ENSP00000442973.1, ENST00000545797.6
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    3958453..3971123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259508.2XP_005259565.1  death-associated protein kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_005259565.1

    UniProtKB/Swiss-Prot
    O43293
    Related
    ENSP00000301264.3, ENST00000301264.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
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