Format

Send to:

Choose Destination

DAPK3 death associated protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 1613, updated on 9-Jan-2022

Summary

Official Symbol
DAPK3provided by HGNC
Official Full Name
death associated protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:2676
See related
Ensembl:ENSG00000167657 MIM:603289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK; ZIP; ZIPK
Summary
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 16.5), prostate (RPKM 15.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DAPK3 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3958453..3971099, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3958451..3971097, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene RNA, 7SL, cytoplasmic 202, pseudogene Neighboring gene nicotinamide riboside kinase 2 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene protein inhibitor of activated STAT 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
GeneReviews: Not available
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP response element binding protein binding TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton reorganization TAS
Traceable Author Statement
more info
 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell motility TAS
Traceable Author Statement
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 
involved_in regulation of myosin II filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle contraction TAS
Traceable Author Statement
more info
 
involved_in regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
death-associated protein kinase 3
Names
DAP kinase 3
DAP-like kinase
MYPT1 kinase
ZIP-kinase
zipper-interacting protein kinase
NP_001339.1
NP_001362587.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348.3NP_001339.1  death-associated protein kinase 3

    See identical proteins and their annotated locations for NP_001339.1

    Status: REVIEWED

    Source sequence(s)
    AI654829, AK027590, AK074799, DA748997, HY104892
    Consensus CDS
    CCDS12116.1
    UniProtKB/Swiss-Prot
    O43293
    UniProtKB/TrEMBL
    B3KNJ3
    Related
    ENSP00000442973.1, ENST00000545797.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
  2. NM_001375658.1NP_001362587.1  death-associated protein kinase 3

    Status: REVIEWED

    Source sequence(s)
    AC011488
    Related
    ENSP00000301264.3, ENST00000301264.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3958453..3971099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center