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SLC38A10 solute carrier family 38 member 10 [ Homo sapiens (human) ]

Gene ID: 124565, updated on 5-Aug-2018

Summary

Official Symbol
SLC38A10provided by HGNC
Official Full Name
solute carrier family 38 member 10provided by HGNC
Primary source
HGNC:HGNC:28237
See related
Ensembl:ENSG00000157637 MIM:616525; Vega:OTTHUMG00000168049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP1744
Expression
Ubiquitous expression in spleen (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See SLC38A10 in Genome Data Viewer
Location:
17q25.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (81244811..81295433, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79218799..79269233, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371925 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene long intergenic non-protein coding RNA 482 Neighboring gene TMEM105 long non-coding RNA

Genomic regions, transcripts, and products

Phenotypes

NHGRI GWAS Catalog

Description
Joint influence of small-effect genetic variants on human longevity.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35718, FLJ46399, MGC15523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone development IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative sodium-coupled neutral amino acid transporter 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037984.2NP_001033073.1  putative sodium-coupled neutral amino acid transporter 10 isoform a

    See identical proteins and their annotated locations for NP_001033073.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK128330, BC014642, BI194553, BM129331, BQ642219, BU552914, CA447446, HY036951
    Consensus CDS
    CCDS42397.1
    UniProtKB/Swiss-Prot
    Q9HBR0
    Related
    ENSP00000363891.3, OTTHUMP00000237711, ENST00000374759.7, OTTHUMT00000397747
    Conserved Domains (4) summary
    PHA00666
    Location:582739
    PHA00666; putative protease
    COG0814
    Location:14397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_138570.3NP_612637.1  putative sodium-coupled neutral amino acid transporter 10 isoform b

    See identical proteins and their annotated locations for NP_612637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC014642, BQ642219, CA416101, HY036951
    Consensus CDS
    CCDS11780.1
    UniProtKB/Swiss-Prot
    Q9HBR0
    Related
    ENSP00000288439.5, OTTHUMP00000237713, ENST00000288439.9, OTTHUMT00000397751
    Conserved Domains (3) summary
    COG0814
    Location:14397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    81244811..81295433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257019.1XP_005257076.1  putative sodium-coupled neutral amino acid transporter 10 isoform X2

    Conserved Domains (3) summary
    COG0814
    Location:14397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_011524289.1XP_011522591.1  putative sodium-coupled neutral amino acid transporter 10 isoform X3

    Conserved Domains (4) summary
    PHA00666
    Location:589746
    PHA00666; putative protease
    COG0814
    Location:14404
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:488690
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6388
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_011524288.1XP_011522590.1  putative sodium-coupled neutral amino acid transporter 10 isoform X1

    Conserved Domains (3) summary
    COG0814
    Location:14404
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:488690
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6388
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_011524290.1XP_011522592.1  putative sodium-coupled neutral amino acid transporter 10 isoform X4

    Conserved Domains (2) summary
    PRK07764
    Location:449886
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl00456
    Location:2299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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