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Slc38a10 solute carrier family 38, member 10 [ Mus musculus (house mouse) ]

Gene ID: 72055, updated on 2-Nov-2024

Summary

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Official Symbol
Slc38a10provided by MGI
Official Full Name
solute carrier family 38, member 10provided by MGI
Primary source
MGI:MGI:1919305
See related
Ensembl:ENSMUSG00000061306 AllianceGenome:MGI:1919305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810073N04Rik
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within bone development. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SLC38A10 (solute carrier family 38 member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in mammary gland adult (RPKM 28.3), subcutaneous fat pad adult (RPKM 28.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc38a10 in Genome Data Viewer
Location:
11 E2; 11 83.96 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119994777..120042177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120103951..120151351, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120011125-120011308 Neighboring gene STARR-positive B cell enhancer ABC_E382 Neighboring gene predicted gene 11769 Neighboring gene predicted gene, 39486 Neighboring gene STARR-seq mESC enhancer starr_31342 Neighboring gene predicted gene 9734 Neighboring gene regulator of early neurogenesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10(-/-) Mice. Lindberg FA, et al. Genes (Basel), 2023 Mar 30. PMID 37107593, Free PMC Article
  2. Behavioral profiling of SLC38A10 knockout mice using the multivariate concentric square field(TM) test. Lindberg FA, et al. Front Behav Neurosci, 2022. PMID 36620864, Free PMC Article
  3. SLC38A10 Knockout Mice Display a Decreased Body Weight and an Increased Risk-Taking Behavior in the Open Field Test. Lindberg FA, et al. Front Behav Neurosci, 2022. PMID 35677577, Free PMC Article
  4. SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells. Tripathi R, et al. Front Cell Dev Biol, 2022. PMID 35450293, Free PMC Article
  5. SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity. Tripathi R, et al. Front Mol Biosci, 2021. PMID 34026845, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10[-/-] Mice.
    Title: SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10(-/-) Mice.
  2. we have shown that SNAT10 expression is found in most neurons of the mouse brain. It has a unique intracellular localization in several cell lines, strongly suggesting expression in the Golgi. Silencing the expression of SNAT10 in PC12 cells resulted in the reduction of nascent protein synthesis, suggesting that SNAT10 might function as a transceptor.
    Title: SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 38 member 10
Names
amino acid transporter SLC38A10
novel amino acid transporter protein
putative sodium-coupled neutral amino acid transporter 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164798.1 → NP_001158270.1  solute carrier family 38 member 10 isoform 2

    See identical proteins and their annotated locations for NP_001158270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK032245, BC088811, BY308707, BY630861
    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (2) summary
    COG0814
    Location:3 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001164799.1 → NP_001158271.1  solute carrier family 38 member 10 isoform 3

    See identical proteins and their annotated locations for NP_001158271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK032245, AK159948, BY308707, BY630861
    Consensus CDS
    CCDS49000.1
    UniProtKB/TrEMBL
    J3QNE8
    Related
    ENSMUSP00000048675.8, ENSMUST00000045402.14
    Conserved Domains (2) summary
    COG0814
    Location:3 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001164800.1 → NP_001158272.1  solute carrier family 38 member 10 isoform 4

    See identical proteins and their annotated locations for NP_001158272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AK032245, BC082300, BY308707, BY630861
    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (2) summary
    COG0814
    Location:3 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001164801.1 → NP_001158273.1  solute carrier family 38 member 10 isoform 5

    See identical proteins and their annotated locations for NP_001158273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL807824, BC082300, BY308707
    Consensus CDS
    CCDS49002.1
    UniProtKB/Swiss-Prot
    Q5I012
    Related
    ENSMUSP00000057615.9, ENSMUST00000053692.9
    Conserved Domains (1) summary
    cl00456
    Location:6 → 372
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_001164802.1 → NP_001158274.1  solute carrier family 38 member 10 isoform 6

    See identical proteins and their annotated locations for NP_001158274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK007977, BY308707
    Consensus CDS
    CCDS49001.1
    UniProtKB/Swiss-Prot
    Q5I012
    Related
    ENSMUSP00000075989.7, ENSMUST00000076697.13
    Conserved Domains (1) summary
    cl00456
    Location:6 → 378
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. NM_001361696.1 → NP_001348625.1  solute carrier family 38 member 10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL807824
    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    pfam03157
    Location:527 → 1010
    Glutenin_hmw; High molecular weight glutenin subunit
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    cl26511
    Location:407 → 766
    Neuromodulin_N; Gap junction protein N-terminal region

  7. NM_001361697.1 → NP_001348626.1  solute carrier family 38 member 10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL807824
    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    cl25751
    Location:628 → 887
    DUF4045; Domain of unknown function (DUF4045)
    cl26511
    Location:325 → 685
    Neuromodulin_N; Gap junction protein N-terminal region

  8. NM_001361698.1 → NP_001348627.1  solute carrier family 38 member 10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL807824
    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    cl00456
    Location:6 → 293
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    cl25751
    Location:622 → 882
    DUF4045; Domain of unknown function (DUF4045)
    cl26511
    Location:319 → 682
    Neuromodulin_N; Gap junction protein N-terminal region

  9. NM_001361699.1 → NP_001348628.1  solute carrier family 38 member 10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL807824
    Conserved Domains (3) summary
    PTZ00121
    Location:182 → 545
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:485 → 745
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:8 → 156
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  10. NM_024249.5 → NP_077211.4  solute carrier family 38 member 10 isoform 1

    See identical proteins and their annotated locations for NP_077211.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK032245, BC088811, BY308707, BY630861
    Consensus CDS
    CCDS25728.1
    UniProtKB/Swiss-Prot
    A2AMZ5, Q3TVW4, Q5I012, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
    UniProtKB/TrEMBL
    J3QNE8
    Related
    ENSMUSP00000099307.5, ENSMUST00000103018.11
    Conserved Domains (2) summary
    COG0814
    Location:3 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119994777..120042177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246350.1 → XP_030102210.1  solute carrier family 38 member 10 isoform X8

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 724
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:667 → 926
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_017314782.1 → XP_017170271.1  solute carrier family 38 member 10 isoform X7

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (2) summary
    PTZ00121
    Location:407 → 954
    PTZ00121; MAEBL; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_030246349.1 → XP_030102209.1  solute carrier family 38 member 10 isoform X6

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 758
    PTZ00121; MAEBL; Provisional
    pfam03157
    Location:552 → 997
    Glutenin_hmw; High molecular weight glutenin subunit
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006534288.3 → XP_006534351.1  solute carrier family 38 member 10 isoform X5

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 759
    PTZ00121; MAEBL; Provisional
    pfam03157
    Location:552 → 998
    Glutenin_hmw; High molecular weight glutenin subunit
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_006534287.3 → XP_006534350.1  solute carrier family 38 member 10 isoform X4

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 767
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:709 → 969
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_006534285.3 → XP_006534348.1  solute carrier family 38 member 10 isoform X2

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 788
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:730 → 990
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  7. XM_006534286.3 → XP_006534349.1  solute carrier family 38 member 10 isoform X3

    See identical proteins and their annotated locations for XP_006534349.1

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 788
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:731 → 990
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_030246352.2 → XP_030102212.1  solute carrier family 38 member 10 isoform X11

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 688
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:628 → 888
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  9. XM_006534284.3 → XP_006534347.1  solute carrier family 38 member 10 isoform X1

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:407 → 789
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:731 → 991
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  10. XM_036157009.1 → XP_036012902.1  solute carrier family 38 member 10 isoform X15

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:319 → 674
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:614 → 874
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 293
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  11. XM_006534291.3 → XP_006534354.1  solute carrier family 38 member 10 isoform X10

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:319 → 701
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:643 → 903
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:6 → 293
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  12. XM_030246351.1 → XP_030102211.1  solute carrier family 38 member 10 isoform X9

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 707
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:649 → 909
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  13. XM_036157008.1 → XP_036012901.1  solute carrier family 38 member 10 isoform X14

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 680
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:620 → 880
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  14. XM_030246354.1 → XP_030102214.1  solute carrier family 38 member 10 isoform X13

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 684
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:627 → 886
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  15. XM_030246353.1 → XP_030102213.1  solute carrier family 38 member 10 isoform X12

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 685
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:627 → 887
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  16. XM_006534290.3 → XP_006534353.1  solute carrier family 38 member 10 isoform X9

    UniProtKB/TrEMBL
    J3QNE8
    Conserved Domains (3) summary
    PTZ00121
    Location:325 → 707
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:649 → 909
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I012.2 GenPept UniProtKB/Swiss-Prot:Q5I012

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