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TMEM170A transmembrane protein 170A [ Homo sapiens (human) ]

Gene ID: 124491, updated on 22-Sep-2022

Summary

Official Symbol
TMEM170Aprovided by HGNC
Official Full Name
transmembrane protein 170Aprovided by HGNC
Primary source
HGNC:HGNC:29577
See related
Ensembl:ENSG00000166822 AllianceGenome:HGNC:29577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM170
Summary
Involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Located in endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM170A in Genome Data Viewer
Location:
16q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (75443054..75464737, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (81488941..81510632, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75476952..75498635, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene craniofacial development protein 1 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene carbohydrate sulfotransferase 6 Neighboring gene TMEM231 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 170A
Names
transmembrane protein 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304996.2NP_001291925.1  transmembrane protein 170A isoform 2

    See identical proteins and their annotated locations for NP_001291925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC009163, AK298475
    Consensus CDS
    CCDS76901.1
    UniProtKB/Swiss-Prot
    Q8WVE7
    Related
    ENSP00000350230.4, ENST00000357613.8
    Conserved Domains (1) summary
    pfam10190
    Location:42117
    Tmemb_170; Putative transmembrane protein 170
  2. NM_001304997.2NP_001291926.1  transmembrane protein 170A isoform 3

    See identical proteins and their annotated locations for NP_001291926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon and an alternate start codon compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009163, AK094930
    Consensus CDS
    CCDS76900.1
    UniProtKB/TrEMBL
    B3KT46
    Related
    ENSP00000455491.1, ENST00000569540.5
    Conserved Domains (1) summary
    pfam10190
    Location:7102
    Tmemb_170; Putative transmembrane protein 170
  3. NM_001304998.1NP_001291927.1  transmembrane protein 170A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' coding region, uses an alternate splice site in the 3' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AC009163, DA370427
    Consensus CDS
    CCDS76899.1
    UniProtKB/TrEMBL
    H3BRD7
    Related
    ENSP00000456194.1, ENST00000566980.1
    Conserved Domains (1) summary
    pfam10190
    Location:172
    Tmemb_170; Putative transmembrane protein 170
  4. NM_145254.3NP_660297.1  transmembrane protein 170A isoform 1

    See identical proteins and their annotated locations for NP_660297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009163, AK311919
    Consensus CDS
    CCDS10917.1
    UniProtKB/Swiss-Prot
    Q7Z6F3, Q8WVE7
    Related
    ENSP00000454404.1, ENST00000561878.2
    Conserved Domains (1) summary
    pfam10190
    Location:39144
    Tmemb_170; Putative transmembrane protein 170

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    75443054..75464737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022941.2XP_016878430.1  transmembrane protein 170A isoform X4

    UniProtKB/TrEMBL
    H3BS26
    Related
    ENSP00000456509.1, ENST00000567796.1
  2. XM_017022943.2XP_016878432.1  transmembrane protein 170A isoform X6

  3. XM_017022940.2XP_016878429.1  transmembrane protein 170A isoform X3

  4. XM_011522869.3XP_011521171.1  transmembrane protein 170A isoform X1

    Conserved Domains (1) summary
    pfam10190
    Location:36131
    Tmemb_170; Putative transmembrane protein 170
  5. XM_017022942.2XP_016878431.1  transmembrane protein 170A isoform X5

  6. XM_017022939.2XP_016878428.1  transmembrane protein 170A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    81488941..81510632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)