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TMEM170A transmembrane protein 170A [ Homo sapiens (human) ]

Gene ID: 124491, updated on 3-Feb-2021

Summary

Official Symbol
TMEM170Aprovided by HGNC
Official Full Name
transmembrane protein 170Aprovided by HGNC
Primary source
HGNC:HGNC:29577
See related
Ensembl:ENSG00000166822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM170
Expression
Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM170A in Genome Data Viewer
Location:
16q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (75443054..75464757, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75476952..75498635, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371345 Neighboring gene RNA, U6 small nuclear 758, pseudogene Neighboring gene craniofacial development protein 1 Neighboring gene CFDP1 intron CAGE-defined high expression enhancer Neighboring gene carbohydrate sulfotransferase 6 Neighboring gene TMEM231 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • FLJ37611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endoplasmic reticulum tubular network organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 170A
Names
transmembrane protein 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304996.2NP_001291925.1  transmembrane protein 170A isoform 2

    See identical proteins and their annotated locations for NP_001291925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC009163, AK298475
    Consensus CDS
    CCDS76901.1
    UniProtKB/Swiss-Prot
    Q8WVE7
    Related
    ENSP00000350230.4, ENST00000357613.8
    Conserved Domains (1) summary
    pfam10190
    Location:42117
    Tmemb_170; Putative transmembrane protein 170
  2. NM_001304997.2NP_001291926.1  transmembrane protein 170A isoform 3

    See identical proteins and their annotated locations for NP_001291926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon and an alternate start codon compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009163, AK094930
    Consensus CDS
    CCDS76900.1
    UniProtKB/TrEMBL
    B3KT46
    Related
    ENSP00000455491.1, ENST00000569540.5
    Conserved Domains (1) summary
    pfam10190
    Location:7102
    Tmemb_170; Putative transmembrane protein 170
  3. NM_001304998.1NP_001291927.1  transmembrane protein 170A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' coding region, uses an alternate splice site in the 3' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter compared to isoform 1.
    Source sequence(s)
    AC009163, DA370427
    Consensus CDS
    CCDS76899.1
    UniProtKB/TrEMBL
    H3BRD7
    Related
    ENSP00000456194.1, ENST00000566980.1
    Conserved Domains (1) summary
    pfam10190
    Location:172
    Tmemb_170; Putative transmembrane protein 170
  4. NM_145254.3NP_660297.1  transmembrane protein 170A isoform 1

    See identical proteins and their annotated locations for NP_660297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009163, AK311919
    Consensus CDS
    CCDS10917.1
    UniProtKB/Swiss-Prot
    Q8WVE7
    Related
    ENSP00000454404.1, ENST00000561878.2
    Conserved Domains (1) summary
    pfam10190
    Location:39144
    Tmemb_170; Putative transmembrane protein 170

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    75443054..75464757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022941.1XP_016878430.1  transmembrane protein 170A isoform X4

    UniProtKB/TrEMBL
    H3BS26
    Related
    ENSP00000456509.1, ENST00000567796.1
  2. XM_011522869.2XP_011521171.1  transmembrane protein 170A isoform X1

    Conserved Domains (1) summary
    pfam10190
    Location:36131
    Tmemb_170; Putative transmembrane protein 170
  3. XM_017022940.1XP_016878429.1  transmembrane protein 170A isoform X3

  4. XM_017022943.1XP_016878432.1  transmembrane protein 170A isoform X6

  5. XM_017022942.1XP_016878431.1  transmembrane protein 170A isoform X5

  6. XM_017022939.1XP_016878428.1  transmembrane protein 170A isoform X2

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