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FOPNL FGFR1OP N-terminal like [ Homo sapiens (human) ]

Gene ID: 123811, updated on 17-Jun-2019

Summary

Official Symbol
FOPNLprovided by HGNC
Official Full Name
FGFR1OP N-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:26435
See related
Ensembl:ENSG00000133393 MIM:617149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOR20; C16orf63; PHSECRG2
Expression
Ubiquitous expression in thyroid (RPKM 17.8), esophagus (RPKM 13.1) and 25 other tissues See more
Orthologs

Genomic context

See FOPNL in Genome Data Viewer
Location:
16p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (15865719..15888649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15959576..15982510, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12074 Neighboring gene nudE neurodevelopment protein 1 Neighboring gene myosin heavy chain 11 Neighboring gene Sharpr-MPRA regulatory region 5546 Neighboring gene RNA, U6 small nuclear 213, pseudogene Neighboring gene uncharacterized LOC107984869 Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene ATP binding cassette subfamily C member 1 Neighboring gene Sharpr-MPRA regulatory region 4662

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31153, DKFZp686N1651

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
lisH domain-containing protein FOPNL
Names
FOP-related protein of 20 kDa
lisH domain-containing protein C16orf63
pluripotent embryonic stem cell-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304497.2NP_001291426.1  lisH domain-containing protein FOPNL isoform 2

    See identical proteins and their annotated locations for NP_001291426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK056798, AL832498, HY004717
    Consensus CDS
    CCDS76830.1
    UniProtKB/Swiss-Prot
    Q96NB1
    Related
    ENSP00000460312.1, ENST00000573968.5
    Conserved Domains (1) summary
    pfam09398
    Location:4389
    FOP_dimer; FOP N terminal dimerization domain
  2. NM_001304498.2NP_001291427.1  lisH domain-containing protein FOPNL isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AL832498, DB494037
    Consensus CDS
    CCDS76831.1
    UniProtKB/TrEMBL
    I3L2N4
    Related
    ENSP00000459804.1, ENST00000575073.5
    Conserved Domains (1) summary
    pfam09398
    Location:4398
    FOP_dimer; FOP N terminal dimerisation domain
  3. NM_001304499.2NP_001291428.1  lisH domain-containing protein FOPNL isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AL832498, BI460301, HY004717
    Consensus CDS
    CCDS76833.1
    UniProtKB/TrEMBL
    I3NI25
    Related
    ENSP00000461830.1, ENST00000573429.5
    Conserved Domains (1) summary
    pfam09398
    Location:43137
    FOP_dimer; FOP N terminal dimerization domain
  4. NM_001304500.2NP_001291429.1  lisH domain-containing protein FOPNL isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL832498, DB103294, HY004717
    Consensus CDS
    CCDS76829.1
    UniProtKB/TrEMBL
    I3L269
    Related
    ENSP00000459429.1, ENST00000575744.5
    Conserved Domains (1) summary
    pfam09398
    Location:347
    FOP_dimer; FOP N terminal dimerization domain
  5. NM_001304502.2NP_001291431.1  lisH domain-containing protein FOPNL isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate in-frame exon in the 5' coding region and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AL832498, BI460301, BI551732, HY004717
    Consensus CDS
    CCDS76832.1
    UniProtKB/TrEMBL
    I3L4V2
    Related
    ENSP00000461548.1, ENST00000573396.5
    Conserved Domains (1) summary
    pfam09398
    Location:43122
    FOP_dimer; FOP N terminal dimerization domain
  6. NM_144600.4NP_653201.1  lisH domain-containing protein FOPNL isoform 1

    See identical proteins and their annotated locations for NP_653201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK055715, AL832498, HY004717
    Consensus CDS
    CCDS10567.1
    UniProtKB/Swiss-Prot
    Q96NB1
    Related
    ENSP00000255759.6, ENST00000255759.11
    Conserved Domains (1) summary
    pfam09398
    Location:43113
    FOP_dimer; FOP N terminal dimerisation domain

RNA

  1. NR_130755.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL832498, BI550657, HY004717
  2. NR_130756.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL832498, CB991926, DA178808, HY004717
  3. NR_130757.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because there are no ORFs that meet RefSeq quality criteria.
    Source sequence(s)
    AL832498, BU661163, HY004717

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    15865719..15888649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1523718..1546650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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