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IKBIP IKBKB interacting protein [ Homo sapiens (human) ]

Gene ID: 121457, updated on 7-Oct-2018

Summary

Official Symbol
IKBIPprovided by HGNC
Official Full Name
IKBKB interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:26430
See related
Ensembl:ENSG00000166130 MIM:609861; Vega:OTTHUMG00000170213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKIP
Expression
Ubiquitous expression in placenta (RPKM 6.8), urinary bladder (RPKM 5.4) and 24 other tissues See more
Orthologs

Genomic context

See IKBIP in Genome Data Viewer
Location:
12q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (98613404..98645051, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (99007182..99038829, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene peptidylprolyl isomerase A pseudogene 8 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IKBIP; predicted interaction to be within the endoplasmic reticulum and involved in NFKB circuitry PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
response to X-ray TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase-interacting protein
Names
I kappa B kinase interacting protein
IKK interacting protein
i kappa-B kinase-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153687.3NP_710154.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_710154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ539425, BC058933, BM468651
    Consensus CDS
    CCDS9068.1
    UniProtKB/Swiss-Prot
    Q70UQ0
    Related
    ENSP00000299157.4, OTTHUMP00000243254, ENST00000299157.4, OTTHUMT00000408005
    Conserved Domains (1) summary
    cl25732
    Location:83348
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_201612.2NP_963906.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_963906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 3'-terminal exon, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AJ539426, BM468651
    Consensus CDS
    CCDS9067.1
    UniProtKB/Swiss-Prot
    Q70UQ0
    Related
    ENSP00000343471.2, OTTHUMP00000243252, ENST00000342502.6, OTTHUMT00000408003
    Conserved Domains (1) summary
    cl23887
    Location:59222
    DUF4349; Domain of unknown function (DUF4349)
  3. NM_201613.2NP_963907.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 3

    See identical proteins and their annotated locations for NP_963907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon at its 3'-terminal exon and lacks an internal exon, compared to variant 1, which results in a protein (isoform 3; also known as 3.1) with a shorter and distinct C-terminus, compared to isoform 1. The 3'-terminal exon of variant 3 contains a longer ORF which can potentially encode a protein (called isoform 3.2) that matches the C-terminus of isoform 2; however, this protein is not predicted to be translated because the ORF is overlapped by the upstream ORF encoding isoform 3.
    Source sequence(s)
    AJ539427, BM468651
    Consensus CDS
    CCDS41822.1
    UniProtKB/Swiss-Prot
    Q70UQ0
    Related
    ENSP00000376762.3, OTTHUMP00000243253, ENST00000393042.3, OTTHUMT00000408004

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    98613404..98645051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448836.1XP_024304604.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:8238
    SMC_N; RecF/RecN/SMC N terminal domain
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