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PRAP1 proline rich acidic protein 1 [ Homo sapiens (human) ]

Gene ID: 118471, updated on 5-Aug-2022

Summary

Official Symbol
PRAP1provided by HGNC
Official Full Name
proline rich acidic protein 1provided by HGNC
Primary source
HGNC:HGNC:23304
See related
Ensembl:ENSG00000165828 MIM:609776; AllianceGenome:HGNC:23304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UPA; PRO1195
Summary
Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues See more
Orthologs
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Genomic context

See PRAP1 in Genome Data Viewer
Location:
10q26.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133347373..133352683)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134302524..134307799)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135160877..135166187)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene calcyon neuron specific vesicular protein Neighboring gene BANF1 pseudogene 2 Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF511-PRAP1

Readthrough gene: ZNF511-PRAP1, Included gene: ZNF511

Homology

Clone Names

  • MGC126792

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables triglyceride binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proline-rich acidic protein 1
Names
epididymis secretory sperm binding protein
epididymis tissue protein Li 178

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145201.2NP_001138673.1  proline-rich acidic protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL360181, BC071872, DQ884405
    Consensus CDS
    CCDS44498.1
    UniProtKB/Swiss-Prot
    Q96NZ9
    UniProtKB/TrEMBL
    A6XND8
    Related
    ENSP00000486265.1, ENST00000463201.2
    Conserved Domains (1) summary
    pfam15314
    Location:96140
    PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine
  2. NM_145202.5NP_660203.3  proline-rich acidic protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_660203.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL360181, BC071872
    Consensus CDS
    CCDS7679.1
    UniProtKB/Swiss-Prot
    Q8NCS2, Q96NZ9
    Related
    ENSP00000416126.2, ENST00000433452.6
    Conserved Domains (1) summary
    pfam15314
    Location:105149
    PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133347373..133352683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134302524..134307799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)