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Birc2 baculoviral IAP repeat-containing 2 [ Mus musculus (house mouse) ]

Gene ID: 11797, updated on 8-Feb-2024

Summary

Official Symbol
Birc2provided by MGI
Official Full Name
baculoviral IAP repeat-containing 2provided by MGI
Primary source
MGI:MGI:1197009
See related
Ensembl:ENSMUSG00000057367 AllianceGenome:MGI:1197009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc3; HIAP1; HIAP2; MIAP1; MIAP2; RNF48; cIAP1; cIAP2; C-IAP1; mcIAP1; C330006D17Rik
Summary
Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in necroptotic process. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in brain ventricular layer; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.0), CNS E14 (RPKM 8.3) and 26 other tissues See more
Orthologs
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Genomic context

See Birc2 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7818227..7837123, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7818226..7837131, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2884 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7764868-7765169 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene transmembrane protein 123 Neighboring gene STARR-seq mESC enhancer starr_23223 Neighboring gene microRNA 5618 Neighboring gene STARR-seq mESC enhancer starr_23227 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7872853-7873154 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7873159-7873459 Neighboring gene baculoviral IAP repeat-containing 3 Neighboring gene STARR-seq mESC enhancer starr_23228 Neighboring gene STARR-seq mESC enhancer starr_23230 Neighboring gene STARR-seq mESC enhancer starr_23231 Neighboring gene yes-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_23234 Neighboring gene STARR-seq mESC enhancer starr_23236 Neighboring gene STARR-seq mESC enhancer starr_23238

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FBXO family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein polyubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in XY body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 2
Names
IAP-2
RING-type E3 ubiquitin transferase BIRC2
apoptosis inhibitor 2
baculoviral IAP repeat-containing 3
cellular inhibitor of apoptosis 1
inhibitor of apoptosis protein 2
mIAP-2
NP_001278432.1
NP_031491.2
XP_017168599.1
XP_017168600.1
XP_030099889.1
XP_036010465.1
XP_036010466.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291503.1NP_001278432.1  baculoviral IAP repeat-containing protein 2

    See identical proteins and their annotated locations for NP_001278432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AA144490, BC145985, CT030639
    Consensus CDS
    CCDS22811.1
    UniProtKB/Swiss-Prot
    A6H6S7, O08864, Q62210
    Conserved Domains (5) summary
    smart00238
    Location:176245
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:447538
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:559612
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  2. NM_007465.3NP_031491.2  baculoviral IAP repeat-containing protein 2

    See identical proteins and their annotated locations for NP_031491.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AA144490, BC145985, CT030639
    Consensus CDS
    CCDS22811.1
    UniProtKB/Swiss-Prot
    A6H6S7, O08864, Q62210
    Related
    ENSMUSP00000140049.2, ENSMUST00000190341.7
    Conserved Domains (5) summary
    smart00238
    Location:176245
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:447538
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:559612
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7818227..7837123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313111.2XP_017168600.1  baculoviral IAP repeat-containing protein 2 isoform X2

    Conserved Domains (5) summary
    smart00238
    Location:45114
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:474527
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:180244
    BIR; Inhibitor of Apoptosis domain
  2. XM_030244029.2XP_030099889.1  baculoviral IAP repeat-containing protein 2 isoform X2

    Conserved Domains (5) summary
    smart00238
    Location:45114
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:474527
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:180244
    BIR; Inhibitor of Apoptosis domain
  3. XM_036154572.1XP_036010465.1  baculoviral IAP repeat-containing protein 2 isoform X2

    Conserved Domains (5) summary
    smart00238
    Location:45114
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:474527
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:180244
    BIR; Inhibitor of Apoptosis domain
  4. XM_017313110.2XP_017168599.1  baculoviral IAP repeat-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6H6S7, O08864, Q62210
    Related
    ENSMUSP00000091422.5, ENSMUST00000074246.7
    Conserved Domains (5) summary
    smart00238
    Location:176245
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:447538
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:385431
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:559612
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  5. XM_036154573.1XP_036010466.1  baculoviral IAP repeat-containing protein 2 isoform X3

    Conserved Domains (3) summary
    smart00238
    Location:45114
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:263329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam00653
    Location:180244
    BIR; Inhibitor of Apoptosis domain

RNA

  1. XR_004935314.1 RNA Sequence

  2. XR_004935313.1 RNA Sequence