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BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens (human) ]

Gene ID: 329, updated on 13-Mar-2020

Summary

Official Symbol
BIRC2provided by HGNC
Official Full Name
baculoviral IAP repeat containing 2provided by HGNC
Primary source
HGNC:HGNC:590
See related
Ensembl:ENSG00000110330 MIM:601712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See BIRC2 in Genome Data Viewer
Location:
11q22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (102347182..102378670)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102217913..102249401)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 952, pseudogene Neighboring gene baculoviral IAP repeat containing 3 Neighboring gene transmembrane protein 123 Neighboring gene uncharacterized LOC101928424

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of baculoviral IAP repeat containing 2 (BIRC2) in human B cells PubMed
Vpr vpr Anti-apoptotic proteins cIAP1 and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FBXO family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
necroptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ripoptosome assembly involved in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
placenta development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of RIG-I signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of necroptotic process TAS
Traceable Author Statement
more info
 
regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
XY body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 2
Names
IAP homolog B
IAP-2
NFR2-TRAF signalling complex protein
RING finger protein 48
RING-type E3 ubiquitin transferase BIRC2
TNFR2-TRAF-signaling complex protein 2
apoptosis inhibitor 1
cellular inhibitor of apoptosis 1
inhibitor of apoptosis protein 2
NP_001157.1
NP_001243092.1
NP_001243095.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166.4NP_001157.1  baculoviral IAP repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC028578, BX647978, DA115985
    Consensus CDS
    CCDS8316.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000227758.2, ENST00000227758.6
    Conserved Domains (5) summary
    smart00238
    Location:268336
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:49115
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:453544
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:391437
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:565618
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  2. NM_001256163.1NP_001243092.1  baculoviral IAP repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001243092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC028578, DA094075
    Consensus CDS
    CCDS8316.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000477613.1, ENST00000613397.4
    Conserved Domains (5) summary
    smart00238
    Location:268336
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:49115
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:453544
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:391437
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:565618
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  3. NM_001256166.2NP_001243095.1  baculoviral IAP repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001243095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303197, BC028578, DA115985
    Consensus CDS
    CCDS58169.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000431723.1, ENST00000530675.5
    Conserved Domains (5) summary
    smart00238
    Location:219287
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:166
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:404495
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:342388
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:518563
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    102347182..102378670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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