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BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens (human) ]

Gene ID: 329, updated on 6-May-2021

Summary

Official Symbol
BIRC2provided by HGNC
Official Full Name
baculoviral IAP repeat containing 2provided by HGNC
Primary source
HGNC:HGNC:590
See related
Ensembl:ENSG00000110330 MIM:601712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues See more
Orthologs
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Genomic context

See BIRC2 in Genome Data Viewer
Location:
11q22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (102347214..102378670)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102217913..102249401)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 952, pseudogene Neighboring gene baculoviral IAP repeat containing 3 Neighboring gene transmembrane protein 123 Neighboring gene TMEM123 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of baculoviral IAP repeat containing 2 (BIRC2) in human B cells PubMed
Vpr vpr Anti-apoptotic proteins cIAP1 and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FBXO family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity EXP
Inferred from Experiment
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
involved_in MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of ripoptosome assembly involved in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RIG-I signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of necroptotic process TAS
Traceable Author Statement
more info
 
involved_in regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
part_of CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in XY body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 2
Names
IAP homolog B
IAP-2
NFR2-TRAF signalling complex protein
RING finger protein 48
RING-type E3 ubiquitin transferase BIRC2
TNFR2-TRAF-signaling complex protein 2
apoptosis inhibitor 1
cellular inhibitor of apoptosis 1
inhibitor of apoptosis protein 2
NP_001157.1
NP_001243092.1
NP_001243095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166.5NP_001157.1  baculoviral IAP repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AP000942
    Consensus CDS
    CCDS8316.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000227758.2, ENST00000227758.6
    Conserved Domains (5) summary
    smart00238
    Location:268336
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:49115
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:453544
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:391437
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:565618
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  2. NM_001256163.1NP_001243092.1  baculoviral IAP repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001243092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC028578, DA094075
    Consensus CDS
    CCDS8316.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000477613.1, ENST00000613397.4
    Conserved Domains (5) summary
    smart00238
    Location:268336
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:49115
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:453544
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:391437
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:565618
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
  3. NM_001256166.2NP_001243095.1  baculoviral IAP repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001243095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303197, BC028578, DA115985
    Consensus CDS
    CCDS58169.1
    UniProtKB/Swiss-Prot
    Q13490
    Related
    ENSP00000431723.1, ENST00000530675.5
    Conserved Domains (5) summary
    smart00238
    Location:219287
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:166
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd08329
    Location:404495
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd14394
    Location:342388
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:518563
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    102347214..102378670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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