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ADCY8 adenylate cyclase 8 [ Homo sapiens (human) ]

Gene ID: 114, updated on 29-Mar-2020

Summary

Official Symbol
ADCY8provided by HGNC
Official Full Name
adenylate cyclase 8provided by HGNC
Primary source
HGNC:HGNC:239
See related
Ensembl:ENSG00000155897 MIM:103070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC8; ADCY3; HBAC1
Summary
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.1), lung (RPKM 0.8) and 2 other tissues See more
Orthologs

Genomic context

See ADCY8 in Genome Data Viewer
Location:
8q24.22
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (130780300..131041604, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131792546..132053012, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375758 Neighboring gene NFE2L2 motif-containing MPRA enhancer 239 Neighboring gene uncharacterized LOC105375762 Neighboring gene uncharacterized LOC105375761 Neighboring gene uncharacterized LOC105375760 Neighboring gene uncharacterized LOC105375759 Neighboring gene uncharacterized LOC105375763

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
NHGRI GWA Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity TAS
Traceable Author Statement
more info
 
calcium- and calmodulin-responsive adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 
activation of protein kinase A activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucagon stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to morphine ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
learning or memory TAS
Traceable Author Statement
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex oligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
renal water homeostasis TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic active zone ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adenylate cyclase type 8
Names
ATP pyrophosphate-lyase 8
HEL-S-172mP
adenylate cyclase 8 (brain)
adenylate cyclase type VIII
adenylyl cyclase 8
adenylyl cyclase-8, brain
ca(2+)/calmodulin-activated adenylyl cyclase
epididymis secretory sperm binding protein Li 172mP
NP_001106.1
XP_005250826.1
XP_006716564.1
XP_016868495.1
XP_016868496.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115.3NP_001106.1  adenylate cyclase type 8

    See identical proteins and their annotated locations for NP_001106.1

    Status: REVIEWED

    Source sequence(s)
    AC087341, AC103726, DQ104739, DR003657, Z35309
    Consensus CDS
    CCDS6363.1
    UniProtKB/Swiss-Prot
    P40145
    UniProtKB/TrEMBL
    A0A0K0K1K3, Q4F7X0
    Related
    ENSP00000286355.5, ENST00000286355.10
    Conserved Domains (4) summary
    smart00044
    Location:366564
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9731172
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:617711
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:161400
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    130780300..131041604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716501.3XP_006716564.1  adenylate cyclase type 8 isoform X2

    Conserved Domains (4) summary
    smart00044
    Location:366564
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9071106
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:617639
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:161400
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. XM_017013006.1XP_016868495.1  adenylate cyclase type 8 isoform X3

  3. XM_005250769.3XP_005250826.1  adenylate cyclase type 8 isoform X1

    Related
    ENSP00000367161.3, ENST00000377928.7
    Conserved Domains (4) summary
    smart00044
    Location:366564
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9431142
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:617711
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:161400
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  4. XM_017013007.1XP_016868496.1  adenylate cyclase type 8 isoform X4

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