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Adcy8 adenylate cyclase 8 [ Mus musculus (house mouse) ]

Gene ID: 11514, updated on 5-Jan-2023

Summary

Official Symbol
Adcy8provided by MGI
Official Full Name
adenylate cyclase 8provided by MGI
Primary source
MGI:MGI:1341110
See related
Ensembl:ENSMUSG00000022376 AllianceGenome:MGI:1341110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC8
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is integral component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 13.1), genital fat pad adult (RPKM 11.8) and 8 other tissues See more
Orthologs
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Genomic context

See Adcy8 in Genome Data Viewer
Location:
15 D1; 15 29.03 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (64570884..64794145, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (64699035..64922296, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30632 Neighboring gene predicted gene, 30691 Neighboring gene predicted gene, 30752 Neighboring gene PQ loop repeat containing pseudogene Neighboring gene predicted gene 7814

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cAMP-dependent protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular function activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables molecular function inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase A activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucagon stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucagon stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to morphine ISO
Inferred from Sequence Orthology
more info
 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylate cyclase type 8
Names
ATP pyrophosphate-lyase 8
adenylate cyclase type VIII
adenylyl cyclase 8
ca(2+)/calmodulin-activated adenylyl cyclase
NP_001278832.1
NP_001318004.1
NP_033753.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291903.1NP_001278832.1  adenylate cyclase type 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK138244, BC094231
    Consensus CDS
    CCDS88771.1
    UniProtKB/TrEMBL
    A0A2I3BQ46, Q3UUN2
    Related
    ENSMUSP00000154029.2, ENSMUST00000228014.2
    Conserved Domains (4) summary
    smart00044
    Location:364562
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9411140
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:615709
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:159398
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. NM_001331075.1NP_001318004.1  adenylate cyclase type 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC116996, AC160934, BC094231
  3. NM_009623.2NP_033753.2  adenylate cyclase type 8 isoform 1

    See identical proteins and their annotated locations for NP_033753.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK138244, BC094231
    Consensus CDS
    CCDS27506.1
    UniProtKB/Swiss-Prot
    G3X8V9, P97490
    UniProtKB/TrEMBL
    Q3UUN2
    Related
    ENSMUSP00000023007.6, ENSMUST00000023007.7
    Conserved Domains (4) summary
    smart00044
    Location:364562
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9711170
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:615709
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:159398
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    64570884..64794145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)