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GPR182 G protein-coupled receptor 182 [ Homo sapiens (human) ]

Gene ID: 11318, updated on 1-Jun-2020

Summary

Official Symbol
GPR182provided by HGNC
Official Full Name
G protein-coupled receptor 182provided by HGNC
Primary source
HGNC:HGNC:13708
See related
Ensembl:ENSG00000166856 MIM:605307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR
Summary
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 5.1), testis (RPKM 0.9) and 4 other tissues See more
Orthologs

Genomic context

See GPR182 in Genome Data Viewer
Location:
12q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56993590..56998447)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57388355..57390469)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene tachykinin precursor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of G protein-coupled receptor 182 (GPR182) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC34399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 182
Names
adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007264.4NP_009195.1  G-protein coupled receptor 182

    See identical proteins and their annotated locations for NP_009195.1

    Status: REVIEWED

    Source sequence(s)
    AC026120, BC034761
    Consensus CDS
    CCDS8927.1
    UniProtKB/Swiss-Prot
    O15218
    Related
    ENSP00000300098.1, ENST00000300098.3
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56993590..56998447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537825.3XP_011536127.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536127.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011537827.3XP_011536129.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536129.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011537824.3XP_011536126.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536126.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors
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