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GPR182 G protein-coupled receptor 182 [ Homo sapiens (human) ]

Gene ID: 11318, updated on 10-Dec-2024

Summary

Official Symbol
GPR182provided by HGNC
Official Full Name
G protein-coupled receptor 182provided by HGNC
Primary source
HGNC:HGNC:13708
See related
Ensembl:ENSG00000166856 MIM:605307; AllianceGenome:HGNC:13708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR
Summary
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 5.1), testis (RPKM 0.9) and 4 other tissues See more
Orthologs
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Genomic context

See GPR182 in Genome Data Viewer
Location:
12q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56994492..56998877)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56962361..56966316)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57388276..57392231)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 Neighboring gene origin of replication ori6 Neighboring gene uncharacterized LOC124902945 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4568 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene tachykinin precursor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57423222-57424059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6521 Neighboring gene myosin IA Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:57440635-57441834

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of G protein-coupled receptor 182 (GPR182) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC34399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 182
Names
adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007264.4NP_009195.1  G-protein coupled receptor 182

    See identical proteins and their annotated locations for NP_009195.1

    Status: REVIEWED

    Source sequence(s)
    AC026120, BC034761
    Consensus CDS
    CCDS8927.1
    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Related
    ENSP00000300098.1, ENST00000300098.3
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56994492..56998877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428198.1XP_047284154.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
  2. XM_011537827.4XP_011536129.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536129.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011537824.4XP_011536126.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536126.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011537825.4XP_011536127.1  G-protein coupled receptor 182 isoform X1

    See identical proteins and their annotated locations for XP_011536127.1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
    Conserved Domains (1) summary
    cd14988
    Location:54331
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56962361..56966316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370942.1XP_054226917.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
  2. XM_054370943.1XP_054226918.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3
  3. XM_054370944.1XP_054226919.1  G-protein coupled receptor 182 isoform X1

    UniProtKB/Swiss-Prot
    O15218
    UniProtKB/TrEMBL
    Q6LAJ3