Gpr182 G protein-coupled receptor 182 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr182provided by MGI
Official Full Name: G protein-coupled receptor 182provided by MGI
Primary source: MGI:MGI:109545
See related: Ensembl:ENSMUSG00000058396 AllianceGenome:MGI:109545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NOW; AM-R; Admr; MB10; Ackr5; G10-D; Gpcr17; Gpcr22
Summary: Predicted to enable adrenomedullin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; gut; heart; reproductive system; and retina. Orthologous to human GPR182 (G protein-coupled receptor 182). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in lung adult (RPKM 41.9), spleen adult (RPKM 27.7) and 12 other tissues See more
Orthologs: all
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Genomic context

Location:: 10 D3; 10 75.07 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127585471..127587667, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127749602..127751798, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
Title: GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
Title: Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492222

Admr (e-PCR), detects polymorphism
- UniSTS:141038

RH129954 (e-PCR)
- UniSTS:213242

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IDA Inferred from Direct Assay more info	PubMed
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X-C chemokine binding	IDA Inferred from Direct Assay more info	PubMed
enables C-X-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenomedullin receptor activity	ISO Inferred from Sequence Orthology more info
enables receptor decoy activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor decoy activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atypical chemokine receptor 5

Names: G10D; adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.