Alternative titles; symbols
HGNC Approved Gene Symbol: GPR182
Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,994,492-56,998,877 (from NCBI)
The ADMR gene encodes a receptor for adrenomedullin (ADM; 103275), a 52-amino acid peptide involved in vasodilation and body fluid homeostasis (Hanze et al., 1997).
By PCR on human genomic DNA using primers based on the rat ADM receptor (Admr), Hanze et al. (1997) isolated a cDNA encoding human ADMR, which they called AMR. Sequence analysis predicted that the 404-amino acid, 7-transmembrane ADMR protein, which is 73% identical to the rat ADM receptor, contains 2 potential N-terminal N-linked glycosylation sites and several potential ser and thr C-terminal cytoplasmic phosphorylation sites. Northern blot analysis detected highest expression of a major 1.8-kb ADMR transcript in heart, skeletal muscle, liver, pancreas, stomach, spleen, lymph node, bone marrow, adrenal gland, and thyroid, with lower expression in brain, lung, placenta, small intestine, thymus, and leukocytes. Southern blot analysis indicated that ADMR is a single-copy gene.
Hanze, J., Dittrich, K., Dotsch, J., Rascher, W. Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. Biochem. Biophys. Res. Commun. 240: 183-188, 1997. [PubMed: 9367907] [Full Text: https://doi.org/10.1006/bbrc.1997.7631]