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SLCO2B1 solute carrier organic anion transporter family member 2B1 [ Homo sapiens (human) ]

Gene ID: 11309, updated on 3-Nov-2024

Summary

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Official Symbol
SLCO2B1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 2B1provided by HGNC
Primary source
HGNC:HGNC:10962
See related
Ensembl:ENSG00000137491 MIM:604988; AllianceGenome:HGNC:10962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPB; OATP-B; OATP2B1; SLC21A9
Summary
This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Expression
Broad expression in liver (RPKM 44.0), lung (RPKM 34.3) and 23 other tissues See more
Orthologs
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Genomic context

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See SLCO2B1 in Genome Data Viewer
Location:
11q13.4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75151107..75206549)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75080709..75136155)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74862152..74917594)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984358 Neighboring gene olfactory receptor family 2 subfamily AT member 1 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:74853637-74854836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74862992-74863691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74912097-74912598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:74914005-74914871 Neighboring gene TPBGL antisense RNA 1 Neighboring gene uncharacterized LOC124902716 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites. Shirasaka Y, et al. Drug Metab Pharmacokinet, 2012. PMID 22201122
  2. Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer. Wang X, et al. J Clin Oncol, 2016 Feb 1. PMID 26668348, Free PMC Article
  3. Tryptophan Residue Located at the Middle of Putative Transmembrane Domain 11 Is Critical for the Function of Organic Anion Transporting Polypeptide 2B1. Bian J, et al. Mol Pharm, 2016 Oct 3. PMID 27576593
  4. Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery. Hussner J, et al. Vascul Pharmacol, 2015 Sep. PMID 26091578
  5. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Akamine Y, et al. Eur J Clin Pharmacol, 2014 Sep. PMID 24903351

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
    Title: The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
  2. Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.
    Title: Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.
  3. SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.
    Title: SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.
  4. Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
    Title: Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
  5. Association of genetic polymorphisms with local steroid metabolism in human benign breasts.
    Title: Association of genetic polymorphisms with local steroid metabolism in human benign breasts.
  6. Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
    Title: Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
  7. Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
    Title: Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
  8. Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).
    Title: Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).
  9. Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers.
    Title: Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers.
  10. Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24.
    Title: Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24.
Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0880, DKFZp686E0517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables prostaglandin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium-independent organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium-independent organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme catabolic process TAS
Traceable Author Statement
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostaglandin transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-independent organic anion transport TAS
Traceable Author Statement
more info
  
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 2B1
Names
OATP-RP2
organic anion transporter B
organic anion transporter polypeptide-related protein 2
organic anion transporting polypeptide 2B1
solute carrier family 21 (organic anion transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027921.1 RefSeqGene

    Range
    5121..60563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145211.3 → NP_001138683.1  solute carrier organic anion transporter family member 2B1 isoform 2

    See identical proteins and their annotated locations for NP_001138683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF205073, AP001972, BC041095, CK299190, DC362722
    Consensus CDS
    CCDS44683.1
    UniProtKB/TrEMBL
    E9PRW4
    Related
    ENSP00000388912.2, ENST00000428359.6
    Conserved Domains (3) summary
    cd06174
    Location:34 → 230
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:463 → 520
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:28 → 625
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. NM_001145212.3 → NP_001138684.1  solute carrier organic anion transporter family member 2B1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing 3 consecutive coding exons from the 5' end compared to transcript variant 1. However, it maintains the reading frame and results in a shorter isoform (3) lacking a protein segment from the N-terminus compared to isoform 1.
    Source sequence(s)
    AP001972, BC041095, CK299190, DC343392
    Consensus CDS
    CCDS53679.1
    UniProtKB/TrEMBL
    A0A0A0MTF1, E9PRW4
    Related
    ENSP00000436324.1, ENST00000525650.5
    Conserved Domains (1) summary
    cl28910
    Location:46 → 444
    MFS; Major Facilitator Superfamily

  3. NM_007256.5 → NP_009187.1  solute carrier organic anion transporter family member 2B1 isoform 1

    See identical proteins and their annotated locations for NP_009187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP001972, BC041095, CK299190, DC343392
    Consensus CDS
    CCDS8235.1
    UniProtKB/Swiss-Prot
    A0A024R5I4, A8K2G9, B4DGA9, B4DTB0, E7ERN5, E9PPU8, O94956, Q9H2Z0, Q9UFU1
    UniProtKB/TrEMBL
    E9PRW4
    Related
    ENSP00000289575.5, ENST00000289575.10
    Conserved Domains (1) summary
    pfam03137
    Location:50 → 647
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75151107..75206549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017157.2 → XP_016872646.2  solute carrier organic anion transporter family member 2B1 isoform X1

  2. XM_047426333.1 → XP_047282289.1  solute carrier organic anion transporter family member 2B1 isoform X2

  3. XM_047426334.1 → XP_047282290.1  solute carrier organic anion transporter family member 2B1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75080709..75136155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367583.1 → XP_054223558.1  solute carrier organic anion transporter family member 2B1 isoform X2

  2. XM_054367582.1 → XP_054223557.1  solute carrier organic anion transporter family member 2B1 isoform X2

  3. XM_054367581.1 → XP_054223556.1  solute carrier organic anion transporter family member 2B1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94956.3 GenPept UniProtKB/Swiss-Prot:O94956

Gene LinkOut

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