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SLCO2B1 solute carrier organic anion transporter family member 2B1 [ Homo sapiens (human) ]

Gene ID: 11309, updated on 6-Sep-2017
Official Symbol
SLCO2B1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 2B1provided by HGNC
Primary source
HGNC:HGNC:10962
See related
Ensembl:ENSG00000137491 MIM:604988; Vega:OTTHUMG00000165420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPB; OATP-B; OATP2B1; SLC21A9
Summary
This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Orthologs
Location:
11q13.4
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (75150987..75206400)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74862032..74917445)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984358 Neighboring gene olfactory receptor family 2 subfamily AT member 1 pseudogene Neighboring gene uncharacterized LOC105369388 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0880, DKFZp686E0517

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier organic anion transporter family member 2B1
Names
OATP-RP2
organic anion transporter B
organic anion transporter polypeptide-related protein 2
solute carrier family 21 (organic anion transporter), member 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027921.1 RefSeqGene

    Range
    5001..60414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145211.2NP_001138683.1  solute carrier organic anion transporter family member 2B1 isoform 2

    See identical proteins and their annotated locations for NP_001138683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF205073, BC041095, CK299190, DC362722
    Consensus CDS
    CCDS44683.1
    UniProtKB/Swiss-Prot
    O94956
    Related
    ENSP00000388912.2, OTTHUMP00000229681, ENST00000428359.6, OTTHUMT00000383944
    Conserved Domains (3) summary
    cd06174
    Location:34230
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:463520
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:28625
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_001145212.2NP_001138684.1  solute carrier organic anion transporter family member 2B1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing 3 consecutive coding exons from the 5' end compared to transcript variant 1. However, it maintains the reading frame and results in a shorter isoform (3) lacking a protein segment from the N-terminus compared to isoform 1.
    Source sequence(s)
    BC041095, CK299190, DC343392
    Consensus CDS
    CCDS53679.1
    UniProtKB/Swiss-Prot
    O94956
    UniProtKB/TrEMBL
    A0A0A0MTF1
    Related
    ENSP00000436324.1, OTTHUMP00000229674, ENST00000525650.5, OTTHUMT00000383937
    Conserved Domains (2) summary
    cd01330
    Location:341398
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:48503
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. NM_007256.4NP_009187.1  solute carrier organic anion transporter family member 2B1 isoform 1

    See identical proteins and their annotated locations for NP_009187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC041095, CK299190, DC343392
    Consensus CDS
    CCDS8235.1
    UniProtKB/Swiss-Prot
    O94956
    UniProtKB/TrEMBL
    A0A024R5I4
    Related
    ENSP00000289575.5, OTTHUMP00000229671, ENST00000289575.9, OTTHUMT00000383933
    Conserved Domains (1) summary
    pfam03137
    Location:50647
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    75150987..75206400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017157.1XP_016872646.1  solute carrier organic anion transporter family member 2B1 isoform X1

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    74745634..74801048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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