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Slco2b1 solute carrier organic anion transporter family, member 2b1 [ Mus musculus (house mouse) ]

Gene ID: 101488, updated on 28-Dec-2022

Summary

Official Symbol
Slco2b1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 2b1provided by MGI
Primary source
MGI:MGI:1351872
See related
Ensembl:ENSMUSG00000030737 AllianceGenome:MGI:1351872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OATP-B; OATP2B1; Slc21a9
Summary
Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport and transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in apical plasma membrane and basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in blood vessel; brain meninges; and embryo. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 40.1), mammary gland adult (RPKM 19.5) and 17 other tissues See more
Orthologs
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Genomic context

See Slco2b1 in Genome Data Viewer
Location:
7; 7 E1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99307011..99360547, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99657804..99711340, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53384 Neighboring gene predicted gene, 25409 Neighboring gene predicted gene, 34280 Neighboring gene olfactory receptor family 2 subfamily AT member 4 Neighboring gene UTP18, small subunit (SSU) processome component, homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC106224

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within organic anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium-independent icosanoid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier organic anion transporter family member 2B1
Names
organic anion transporting polypeptide 2B1
solute carrier family 21 (organic anion transporter), member 9
solute carrier family 21 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252530.1NP_001239459.1  solute carrier organic anion transporter family member 2B1 isoform 1

    See identical proteins and their annotated locations for NP_001239459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK048120, AK132394, AK163542
    Consensus CDS
    CCDS57567.1
    UniProtKB/Swiss-Prot
    Q8BXB6
    UniProtKB/TrEMBL
    Q3TQJ3, Q3V1K7
    Related
    ENSMUSP00000102703.2, ENSMUST00000107088.8
    Conserved Domains (3) summary
    cd06174
    Location:58301
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:484541
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:52646
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_001252531.1NP_001239460.1  solute carrier organic anion transporter family member 2B1 isoform 2

    See identical proteins and their annotated locations for NP_001239460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different exon for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK041144, AK048120, BY340952
    Consensus CDS
    CCDS21485.1
    UniProtKB/Swiss-Prot
    Q8BLV8, Q8BXB6
    Related
    ENSMUSP00000102701.3, ENSMUST00000107086.9
    Conserved Domains (1) summary
    cl28910
    Location:40577
    MFS; Major Facilitator Superfamily
  3. NM_175316.3NP_780525.1  solute carrier organic anion transporter family member 2B1 isoform 2

    See identical proteins and their annotated locations for NP_780525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different exon for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK048120
    Consensus CDS
    CCDS21485.1
    UniProtKB/Swiss-Prot
    Q8BLV8, Q8BXB6
    Related
    ENSMUSP00000032985.5, ENSMUST00000032985.11
    Conserved Domains (1) summary
    cl28910
    Location:40577
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99307011..99360547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241641.4XP_011239943.1  solute carrier organic anion transporter family member 2B1 isoform X2

    See identical proteins and their annotated locations for XP_011239943.1

    UniProtKB/Swiss-Prot
    Q8BLV8, Q8BXB6
    Conserved Domains (1) summary
    cl28910
    Location:40577
    MFS; Major Facilitator Superfamily
  2. XM_011241640.4XP_011239942.1  solute carrier organic anion transporter family member 2B1 isoform X2

    See identical proteins and their annotated locations for XP_011239942.1

    UniProtKB/Swiss-Prot
    Q8BLV8, Q8BXB6
    Conserved Domains (1) summary
    cl28910
    Location:40577
    MFS; Major Facilitator Superfamily
  3. XM_011241638.4XP_011239940.1  solute carrier organic anion transporter family member 2B1 isoform X1

    See identical proteins and their annotated locations for XP_011239940.1

    Conserved Domains (1) summary
    cl28910
    Location:54591
    MFS; Major Facilitator Superfamily
  4. XM_011241639.1XP_011239941.1  solute carrier organic anion transporter family member 2B1 isoform X1

    See identical proteins and their annotated locations for XP_011239941.1

    Conserved Domains (1) summary
    cl28910
    Location:54591
    MFS; Major Facilitator Superfamily
  5. XM_011241637.4XP_011239939.1  solute carrier organic anion transporter family member 2B1 isoform X1

    See identical proteins and their annotated locations for XP_011239939.1

    Conserved Domains (1) summary
    cl28910
    Location:54591
    MFS; Major Facilitator Superfamily

RNA

  1. XR_004933991.1 RNA Sequence