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KLF8 Kruppel like factor 8 [ Homo sapiens (human) ]

Gene ID: 11279, updated on 1-Aug-2020

Summary

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Official Symbol
KLF8provided by HGNC
Official Full Name
Kruppel like factor 8provided by HGNC
Primary source
HGNC:HGNC:6351
See related
Ensembl:ENSG00000102349 MIM:300286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKLF3; ZNF741
Summary
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Broad expression in skin (RPKM 8.2), fat (RPKM 3.4) and 20 other tissues See more
Orthologs
mouse all

Genomic context

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See KLF8 in Genome Data Viewer
Location:
Xp11.21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (55908123..56291531)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (56258814..56314322)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene XAGE-4 protein Neighboring gene Ras related GTP binding B Neighboring gene GOT2 pseudogene 6 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene ubiquilin 2 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene negative regulator of P-body association

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma. Cheng S, et al. Sci Rep, 2018 Nov 27. PMID 30479372, Free PMC Article
  2. Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer. Li J, et al. Pathol Oncol Res, 2019 Jan. PMID 28986741
  3. KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells. Yi X, et al. Gene, 2016 Jul 1. PMID 26995652
  4. Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil. Shi X, et al. Oncol Rep, 2015 Sep. PMID 26133391
  5. Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition. Liu N, et al. Oncol Rep, 2014 Dec. PMID 25333643

See all (60) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF8-overexpressing hepatocellular carcinoma cells had a higher potential for inducing angiogenesis. The up-regulation of KLF8 increased VEGFA protein levels and induced VEGFA promoter activity by binding to the CACCC region of the VEGFA promoter.
    Title: Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma.
  2. This study has unraveled a novel mechanism of ELF3-AS1-mediated oncogenesis in bladder cancer by reinforcement of ELF3-AS1/KLF8 signaling with potential implications for therapeutic intervention.
    Title: The lncRNA ELF3-AS1 promotes bladder cancer progression by interaction with Krüppel-like factor 8.
  3. High KLF8 expression is associated with Non-Small Cell Lung Cancer.
    Title: Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer.
  4. High KLF8 expression is associated with breast cancer cell invasion, transendothelial migration and metastasis.
    Title: Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.
  5. expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes
    Title: miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells.
  6. Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC.
    Title: KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells.
  7. KLF8 plays a crucial role in proliferation and migration of bladder cancer cells
    Title: KLF8 is required for bladder cancer cell proliferation and migration.
  8. KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis.
    Title: KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.
  9. KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy
    Title: Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer.
  10. KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer
    Title: Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-10-12)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-10-12)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138314, DKFZp686O08126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
  
cytosol IDA
Inferred from Direct Assay
more info
  
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
Krueppel-like factor 8
Names
basic krueppel-like factor 3
basic kruppel-like factor 3
zinc finger protein 741

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011949.2 RefSeqGene

    Range
    329234..388409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159296.2 → NP_001152768.1  Krueppel-like factor 8 isoform 2

    See identical proteins and their annotated locations for NP_001152768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region that causes a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK296156, AL050309, BX322609, DA874419
    Consensus CDS
    CCDS55428.1
    UniProtKB/Swiss-Prot
    O95600
    Related
    ENSP00000364063.3, ENST00000374928.7

  2. NM_001324099.1 → NP_001311028.1  Krueppel-like factor 8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BC105130, BX322609, HF546208
    Consensus CDS
    CCDS87749.1
    UniProtKB/Swiss-Prot
    O95600
    Related
    ENSP00000492126.1, ENST00000640927.1

  3. NM_001324100.1 → NP_001311029.1  Krueppel-like factor 8 isoform 4

    Status: REVIEWED

    Source sequence(s)
    BC105130, BX322609, HF546209
    UniProtKB/Swiss-Prot
    O95600
    Conserved Domains (4) summary
    COG5048
    Location:218 → 271
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220 → 244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:236 → 261
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001324102.1 → NP_001311031.1  Krueppel-like factor 8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050309, BX322609
    Consensus CDS
    CCDS14373.1
    UniProtKB/Swiss-Prot
    O95600
    UniProtKB/TrEMBL
    A0A024R9X4
    Conserved Domains (3) summary
    COG5048
    Location:220 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 345
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001324104.1 → NP_001311033.1  Krueppel-like factor 8 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) initiates at an upstream promoter compared to variant 1.
    Source sequence(s)
    AL050309, AL353698, AL445472, BX322609

  6. NM_001324105.1 → NP_001311034.1  Krueppel-like factor 8 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) initiates at an upstream promoter compared to variant 1.
    Source sequence(s)
    AL050309, AL445472, BX322609

  7. NM_007250.5 → NP_009181.2  Krueppel-like factor 8 isoform 1

    See identical proteins and their annotated locations for NP_009181.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AL050309, BC105130, BX322609
    Consensus CDS
    CCDS14373.1
    UniProtKB/Swiss-Prot
    O95600
    UniProtKB/TrEMBL
    A0A024R9X4
    Related
    ENSP00000417303.1, ENST00000468660.6
    Conserved Domains (3) summary
    COG5048
    Location:220 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 345
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_136704.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC031355, BC105130, BX322609

  2. NR_136705.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB209004, AL050309, BX322609

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    55908123..56291531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724575.2 → XP_006724638.1  Krueppel-like factor 8 isoform X3

    See identical proteins and their annotated locations for XP_006724638.1

    UniProtKB/Swiss-Prot
    O95600
    Conserved Domains (1) summary
    pfam10477
    Location:12 → 202
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  2. XM_011530759.2 → XP_011529061.1  Krueppel-like factor 8 isoform X2

    See identical proteins and their annotated locations for XP_011529061.1

    Conserved Domains (4) summary
    COG5048
    Location:267 → 337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269 → 293
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 340
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024452332.1 → XP_024308100.1  Krueppel-like factor 8 isoform X4

    Related
    ENSP00000431911.1, ENST00000358094.7

  4. XM_005261977.3 → XP_005262034.1  Krueppel-like factor 8 isoform X1

    See identical proteins and their annotated locations for XP_005262034.1

    UniProtKB/Swiss-Prot
    O95600
    UniProtKB/TrEMBL
    A0A024R9X4
    Conserved Domains (3) summary
    COG5048
    Location:220 → 346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 345
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017029250.2 → XP_016884739.1  Krueppel-like factor 8 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:267 → 337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269 → 293
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:315 → 340
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95600.2 GenPept UniProtKB/Swiss-Prot:O95600

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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