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RABL2B RAB, member of RAS oncogene family like 2B [ Homo sapiens (human) ]

Gene ID: 11158, updated on 31-Jul-2021

Summary

Official Symbol
RABL2Bprovided by HGNC
Official Full Name
RAB, member of RAS oncogene family like 2Bprovided by HGNC
Primary source
HGNC:HGNC:9800
See related
Ensembl:ENSG00000079974 MIM:605413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 7.7), lung (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

See RABL2B in Genome Data Viewer
Location:
22q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50767500..50783705, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51205934..51222064, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene acrosin Neighboring gene small nuclear ribonucleoprotein polypeptide A' pseudogene Neighboring gene ribosomal protein L23a pseudogene 82

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ93981, FLJ98216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intraciliary transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003789.3NP_001003789.1  rab-like protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001003789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    BC014879, BC020495, BC024281, BC040495, BC064551, BG177165
    Consensus CDS
    CCDS33683.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    Related
    ENSP00000346940.3, ENST00000354869.7
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  2. NM_001130919.3NP_001124391.1  rab-like protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001124391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8, and 9 all encode the same isoform (1).
    Source sequence(s)
    AC002055, AK308268, BC024281
    Consensus CDS
    CCDS33683.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  3. NM_001130920.3NP_001124392.1  rab-like protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001124392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8 and 9 all encode the same isoform (1).
    Source sequence(s)
    AK313442, BC024281, BX421088
    Consensus CDS
    CCDS33683.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  4. NM_001130921.3NP_001124393.1  rab-like protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001124393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8 and 9 all encode the same isoform (1).
    Source sequence(s)
    AK313442, BC024281
    Consensus CDS
    CCDS33683.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    Related
    ENSP00000378960.3, ENST00000395595.8
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  5. NM_001130922.3NP_001124394.1  rab-like protein 2B isoform 2

    See identical proteins and their annotated locations for NP_001124394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3. Variants 2, 6, 10, 11 and 12 all encode the same isoform (2).
    Source sequence(s)
    AK313442, BC024281, BX432293
    Consensus CDS
    CCDS14102.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    UniProtKB/TrEMBL
    A0A0S2SW46
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  6. NM_001130923.3NP_001124395.1  rab-like protein 2B isoform 3

    See identical proteins and their annotated locations for NP_001124395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 3. Variants 7, 18, 19 and 20 all encode the same isoform (3).
    Source sequence(s)
    AK313442, BC024281, BC075856
    Consensus CDS
    CCDS46738.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    Related
    ENSP00000378958.3, ENST00000395593.7
    Conserved Domains (1) summary
    cd04124
    Location:22191
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  7. NM_001350003.2NP_001336932.1  rab-like protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK313442, BC024281, BX421088, DB445642
    Consensus CDS
    CCDS33683.1
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  8. NM_001350004.2NP_001336933.1  rab-like protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002055, AK313442, BC024281, BX421088, DB445642
    Consensus CDS
    CCDS33683.1
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  9. NM_001350005.2NP_001336934.1  rab-like protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK313442, BC024281, DB189975, DB445642
    Consensus CDS
    CCDS14102.1
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  10. NM_001350006.2NP_001336935.1  rab-like protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF095352, AK313442, BC024281, BC075856
    Consensus CDS
    CCDS14102.1
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  11. NM_001350007.2NP_001336936.1  rab-like protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF095352, AK313442, BC024281, DA156379, DB443254
    Consensus CDS
    CCDS14102.1
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  12. NM_001350008.2NP_001336937.1  rab-like protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856
    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  13. NM_001350009.2NP_001336938.1  rab-like protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, DA156379
    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  14. NM_001350010.2NP_001336939.1  rab-like protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, HY005472
    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  15. NM_001350011.2NP_001336940.1  rab-like protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, BF435772
    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  16. NM_001350012.2NP_001336941.1  rab-like protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, DA156379, DB445642
    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  17. NM_001350013.2NP_001336942.1  rab-like protein 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK313442, BC024281, BC075856, DB445642
    Consensus CDS
    CCDS46738.1
    Conserved Domains (1) summary
    cd04124
    Location:22191
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  18. NM_001350014.2NP_001336943.1  rab-like protein 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK313442, BC024281, BC075856, DA156379
    Consensus CDS
    CCDS46738.1
    Conserved Domains (1) summary
    cd04124
    Location:22191
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  19. NM_001350015.2NP_001336944.1  rab-like protein 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK313442, BC024281, BC075856, HY005472
    Consensus CDS
    CCDS46738.1
    Conserved Domains (1) summary
    cd04124
    Location:22191
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  20. NM_001350016.2NP_001336945.1  rab-like protein 2B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, BG677109
    Conserved Domains (1) summary
    cd04124
    Location:22188
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  21. NM_001350017.2NP_001336946.1  rab-like protein 2B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA312189, AK313442, BC024281, BC075856, BG677109, DA156379, DB443254
    Conserved Domains (1) summary
    cd04124
    Location:22188
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  22. NM_001394054.1NP_001380983.1  rab-like protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002055
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  23. NM_001394055.1NP_001380984.1  rab-like protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002055
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  24. NM_007081.4NP_009012.1  rab-like protein 2B isoform 2

    See identical proteins and their annotated locations for NP_009012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3. Variants 2, 6, 10, 11 and 12 all encode the same isoform (2).
    Source sequence(s)
    AF095352, BC024281, BG177165
    Consensus CDS
    CCDS14102.1
    UniProtKB/Swiss-Prot
    Q9UNT1
    UniProtKB/TrEMBL
    A0A0S2SW46
    Related
    ENSP00000378962.3, ENST00000395598.7
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50767500..50783705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028546.1XP_016884035.1  rab-like protein 2B isoform X1

    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  2. XM_017028556.1XP_016884045.1  rab-like protein 2B isoform X5

    UniProtKB/Swiss-Prot
    Q9UNT1
    UniProtKB/TrEMBL
    A0A0S2SW46
    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  3. XM_017028547.1XP_016884036.1  rab-like protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q9UNT1
    Conserved Domains (1) summary
    cd04124
    Location:22191
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  4. XM_017028552.1XP_016884041.1  rab-like protein 2B isoform X4

    UniProtKB/Swiss-Prot
    Q9UNT1
    Conserved Domains (1) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  5. XM_017028543.1XP_016884032.1  rab-like protein 2B isoform X1

    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  6. XM_017028544.1XP_016884033.1  rab-like protein 2B isoform X1

    Conserved Domains (1) summary
    cd04124
    Location:22192
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  7. XM_017028551.1XP_016884040.1  rab-like protein 2B isoform X3

    Conserved Domains (2) summary
    cd04124
    Location:22187
    RabL2; Rab GTPase-like family 2 (Rab-like2)
    smart00175
    Location:22166
    RAB; Rab subfamily of small GTPases
  8. XM_017028559.2XP_016884048.1  rab-like protein 2B isoform X6

    Related
    ENSP00000378955.1, ENST00000395590.5
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