U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rabl2 RAB, member RAS oncogene family-like 2 [ Mus musculus (house mouse) ]

Gene ID: 68708, updated on 11-Apr-2024

Summary

Official Symbol
Rabl2provided by MGI
Official Full Name
RAB, member RAS oncogene family-like 2provided by MGI
Primary source
MGI:MGI:1915958
See related
Ensembl:ENSMUSG00000022621 AllianceGenome:MGI:1915958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabl2a; 1110031N17Rik
Summary
Enables GTP binding activity. Involved in photoreceptor cell morphogenesis. Acts upstream of or within cilium assembly; flagellated sperm motility; and single fertilization. Located in sperm midpiece. Part of intraciliary transport particle B. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and respiratory system. Orthologous to several human genes including RABL2B (RAB, member of RAS oncogene family like 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 34.2), CNS E18 (RPKM 26.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
15 E3; 15 44.96 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89466730..89476126, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89582527..89591960, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39468 Neighboring gene predicted gene, 36221 Neighboring gene acrosin prepropeptide Neighboring gene STARR-seq mESC enhancer starr_39470 Neighboring gene NMD3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_39471 Neighboring gene predicted gene, 19378

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in photoreceptor cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rab-like protein 2A
Names
RAB, member of RAS oncogene family-like 2
RAB, member of RAS oncogene family-like 2A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026817.3NP_081093.2  rab-like protein 2A

    See identical proteins and their annotated locations for NP_081093.2

    Status: VALIDATED

    Source sequence(s)
    AC122401, BQ887131, BX635556, BY273527
    Consensus CDS
    CCDS49704.1
    UniProtKB/Swiss-Prot
    E9Q9D5, Q3TDG7, Q8K2P9, Q9D133
    Related
    ENSMUSP00000023294.9, ENSMUST00000023294.15
    Conserved Domains (2) summary
    cd04124
    Location:22182
    RabL2; Rab GTPase-like family 2 (Rab-like2)
    smart00175
    Location:22171
    RAB; Rab subfamily of small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89466730..89476126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521326.5XP_006521389.1  rab-like protein 2A isoform X2

    Conserved Domains (1) summary
    cd04124
    Location:22181
    RabL2; Rab GTPase-like family 2 (Rab-like2)
  2. XM_030248730.2XP_030104590.1  rab-like protein 2A isoform X5

    Conserved Domains (1) summary
    cl38936
    Location:197
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_006521327.4XP_006521390.1  rab-like protein 2A isoform X4

    Conserved Domains (1) summary
    cl38936
    Location:1145
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_036159564.1XP_036015457.1  rab-like protein 2A isoform X6

    Conserved Domains (1) summary
    cl38936
    Location:196
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_036159563.1XP_036015456.1  rab-like protein 2A isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:5150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_030248727.2XP_030104587.1  rab-like protein 2A isoform X1

    Related
    ENSMUST00000165747.8
    Conserved Domains (1) summary
    cl38936
    Location:141186
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases