Format

Send to:

Choose Destination

PTPRT protein tyrosine phosphatase, receptor type T [ Homo sapiens (human) ]

Gene ID: 11122, updated on 8-Dec-2018

Summary

Official Symbol
PTPRTprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Tprovided by HGNC
Primary source
HGNC:HGNC:9682
See related
Ensembl:ENSG00000196090 MIM:608712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPTPrho
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 9.9) and placenta (RPKM 1.1) See more
Orthologs

Genomic context

See PTPRT in Genome Data Viewer
Location:
20q12-q13.11
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (42029959..43189917, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (40701392..41818557, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927182 Neighboring gene uncharacterized LOC105372622 Neighboring gene neurofilament heavy polypeptide pseudogene Neighboring gene uncharacterized LOC105372624 Neighboring gene uncharacterized LOC101927159 Neighboring gene uncharacterized LOC105372623 Neighboring gene uncharacterized LOC101927138 Neighboring gene RNA, 7SK small nuclear pseudogene 100 Neighboring gene RNA, 7SL, cytoplasmic 666, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
delta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
gamma-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase T
Names
R-PTP-T
RPTP-rho
receptor protein tyrosine phosphatase
receptor-type tyrosine-protein phosphatase rho
NP_008981.4
NP_573400.3
XP_016883100.1
XP_016883101.1
XP_016883102.1
XP_024307588.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033880.1 RefSeqGene

    Range
    5001..1122166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007050.5NP_008981.4  receptor-type tyrosine-protein phosphatase T isoform 2 precursor

    See identical proteins and their annotated locations for NP_008981.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a fragment within the coding region when compared to variant 1. The translation remains in-frame, and thus encodes a protein that lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB006621, AF043644, AL021395, AL707728, DA791336, R50970
    Consensus CDS
    CCDS42874.1
    UniProtKB/Swiss-Prot
    O14522
    Related
    ENSP00000362283.1, ENST00000373187.5
    Conserved Domains (7) summary
    cd06263
    Location:32189
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:29189
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8881142
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9151142
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:502584
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294360
    fn3; Fibronectin type III domain
    cl11960
    Location:196281
    Ig; Immunoglobulin domain
  2. NM_133170.3NP_573400.3  receptor-type tyrosine-protein phosphatase T isoform 1 precursor

    See identical proteins and their annotated locations for NP_573400.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB006621, AF043644, AL021395, AL707728, DA791336, R50970
    Consensus CDS
    CCDS68127.1
    UniProtKB/Swiss-Prot
    O14522
    UniProtKB/TrEMBL
    A0A075B6H0
    Related
    ENSP00000362294.4, ENST00000373198.8
    Conserved Domains (7) summary
    cd06263
    Location:32189
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:29189
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9071161
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9341161
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:502584
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294360
    fn3; Fibronectin type III domain
    cl11960
    Location:196281
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    42029959..43189917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451820.1XP_024307588.1  receptor-type tyrosine-protein phosphatase T isoform X1

    Conserved Domains (4) summary
    smart00137
    Location:29189
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00047
    Location:9851222
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:390480
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:502577
    fn3; Fibronectin type III domain
  2. XM_017027611.1XP_016883100.1  receptor-type tyrosine-protein phosphatase T isoform X2

    Related
    ENSP00000362280.1, ENST00000373184.5
  3. XM_017027612.1XP_016883101.1  receptor-type tyrosine-protein phosphatase T isoform X3

  4. XM_017027613.1XP_016883102.1  receptor-type tyrosine-protein phosphatase T isoform X4

Support Center