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Ptprt protein tyrosine phosphatase, receptor type, T [ Mus musculus (house mouse) ]

Gene ID: 19281, updated on 19-Apr-2019

Summary

Official Symbol
Ptprtprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Tprovided by MGI
Primary source
MGI:MGI:1321152
See related
Ensembl:ENSMUSG00000053141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R-PTP-T; RPTPrho; RPTP-rfo; RPTP-rho; RPTPmam4; mRPTPrho; mKIAA0283
Expression
Biased expression in frontal lobe adult (RPKM 6.3), cortex adult (RPKM 4.2) and 4 other tissues See more
Orthologs

Genomic context

See Ptprt in Genome Data Viewer
Location:
2 H2; 2 81.91 cM
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (161521988..162661147, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (161353359..162486883, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35374 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene protein tyrosine phosphatase, receptor type T, opposite strand Neighboring gene predicted gene, 46774 Neighboring gene RIKEN cDNA 9430021M05 gene Neighboring gene predicted gene 14246

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • KIAA0283

Gene Ontology Provided by MGI

Function Evidence Code Pubs
STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
alpha-actinin binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
delta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
delta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
gamma-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
thiolester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
negative regulation of STAT cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase T
Names
receptor protein tyrosine phosphatase-rho
receptor-type tyrosine-protein phosphatase rho
NP_001278078.1
NP_001278079.1
NP_001278080.1
NP_067439.1
XP_011237686.1
XP_011237687.1
XP_017172075.1
XP_017172076.1
XP_017172079.1
XP_017172081.1
XP_017172082.1
XP_017172083.1
XP_017172084.1
XP_017172086.1
XP_017172087.1
XP_017172089.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291149.1NP_001278078.1  receptor-type tyrosine-protein phosphatase T isoform a precursor

    See identical proteins and their annotated locations for NP_001278078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL590415, AL591586, AL591598, AL591675, AL606841, AL645736, BM900160
    Consensus CDS
    CCDS71182.1
    UniProtKB/Swiss-Prot
    Q99M80
    Related
    ENSMUSP00000105067.1, ENSMUST00000109441.1
    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8821156
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9091156
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain
  2. NM_001291150.1NP_001278079.1  receptor-type tyrosine-protein phosphatase T isoform b precursor

    See identical proteins and their annotated locations for NP_001278079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame exon but lacks a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AL590415, AL591586, AL591598, AL591675, AL606841, AL645736, BM900160
    Consensus CDS
    CCDS71183.1
    UniProtKB/Swiss-Prot
    Q99M80
    Related
    ENSMUSP00000105069.1, ENSMUST00000109443.7
    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8921146
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9191146
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain
  3. NM_001291151.1NP_001278080.1  receptor-type tyrosine-protein phosphatase T isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an additional in-frame exon but lacks a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AL590415, AL591586, AL591598, AL591675, AL606841, AL645736, BM900160
    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8911145
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9181145
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain
  4. NM_021464.5NP_067439.1  receptor-type tyrosine-protein phosphatase T isoform d precursor

    See identical proteins and their annotated locations for NP_067439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AL590415, AL591586, AL591598, AL591675, AL606841, AL645736, BM900160
    Consensus CDS
    CCDS17001.1
    UniProtKB/Swiss-Prot
    Q99M80
    Related
    ENSMUSP00000105071.2, ENSMUST00000109445.8
    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8821136
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9091136
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    161521988..162661147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316586.1XP_017172075.1  receptor-type tyrosine-protein phosphatase T isoform X1

    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9141188
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9411188
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain
  2. XM_017316600.1XP_017172089.1  receptor-type tyrosine-protein phosphatase T isoform X10

  3. XM_011239384.2XP_011237686.1  receptor-type tyrosine-protein phosphatase T isoform X11

    UniProtKB/Swiss-Prot
    Q99M80
    Conserved Domains (7) summary
    cd06263
    Location:36193
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:36193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8951149
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9221149
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:506588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:298364
    fn3; Fibronectin type III domain
    cl11960
    Location:200285
    Ig; Immunoglobulin domain
  4. XM_017316595.1XP_017172084.1  receptor-type tyrosine-protein phosphatase T isoform X7

  5. XM_017316593.1XP_017172082.1  receptor-type tyrosine-protein phosphatase T isoform X5

  6. XM_017316598.1XP_017172087.1  receptor-type tyrosine-protein phosphatase T isoform X9

    UniProtKB/TrEMBL
    B1AQN2
    Related
    ENSMUSP00000105068.1, ENSMUST00000109442.7
  7. XM_017316592.1XP_017172081.1  receptor-type tyrosine-protein phosphatase T isoform X4

  8. XM_017316597.1XP_017172086.1  receptor-type tyrosine-protein phosphatase T isoform X8

  9. XM_017316590.1XP_017172079.1  receptor-type tyrosine-protein phosphatase T isoform X3

  10. XM_017316587.1XP_017172076.1  receptor-type tyrosine-protein phosphatase T isoform X2

  11. XM_017316594.1XP_017172083.1  receptor-type tyrosine-protein phosphatase T isoform X6

  12. XM_011239385.2XP_011237687.1  receptor-type tyrosine-protein phosphatase T isoform X12

    Conserved Domains (7) summary
    cd06263
    Location:7126
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:1126
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8471121
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8741121
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:439521
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:231297
    fn3; Fibronectin type III domain
    cl11960
    Location:133218
    Ig; Immunoglobulin domain
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