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SPACA9 sperm acrosome associated 9 [ Homo sapiens (human) ]

Gene ID: 11092, updated on 11-Sep-2019

Summary

Official Symbol
SPACA9provided by HGNC
Official Full Name
sperm acrosome associated 9provided by HGNC
Primary source
HGNC:HGNC:1367
See related
Ensembl:ENSG00000165698 MIM:618552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mast; C9orf9
Expression
Broad expression in testis (RPKM 17.0), thyroid (RPKM 3.5) and 15 other tissues See more
Orthologs

Genomic context

See SPACA9 in Genome Data Viewer
Location:
9q34.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (132878320..132890314)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135754282..135765419)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 31 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene Sharpr-MPRA regulatory region 7884 Neighboring gene adenylate kinase 8 Neighboring gene TSC complex subunit 1 Neighboring gene microRNA 548aw Neighboring gene growth factor independent 1B transcriptional repressor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sperm acrosome-associated protein 9
Names
Rsb66 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316897.2NP_001303826.1  sperm acrosome-associated protein 9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK075259, BC012940
    Consensus CDS
    CCDS83434.1
    UniProtKB/Swiss-Prot
    Q96E40
    UniProtKB/TrEMBL
    A0A024R8F2
    Related
    ENSP00000348659.5, ENST00000356311.10
    Conserved Domains (1) summary
    pfam15120
    Location:1163
    DUF4561; Domain of unknown function (DUF4561)
  2. NM_001316898.2NP_001303827.1  sperm acrosome-associated protein 9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC012940, DA134573
    Consensus CDS
    CCDS83434.1
    UniProtKB/Swiss-Prot
    Q96E40
    UniProtKB/TrEMBL
    A0A024R8F2
    Related
    ENSP00000361209.3, ENST00000372136.7
    Conserved Domains (1) summary
    pfam15120
    Location:1163
    DUF4561; Domain of unknown function (DUF4561)
  3. NM_001316900.2NP_001303829.1  sperm acrosome-associated protein 9 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment in the 3' end compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL445645, BC012940, CK906174, CK906175, HY024188
    UniProtKB/Swiss-Prot
    Q96E40
    Conserved Domains (1) summary
    pfam15120
    Location:1164
    DUF4561; Domain of unknown function (DUF4561)
  4. NM_018956.5NP_061829.3  sperm acrosome-associated protein 9 isoform b

    See identical proteins and their annotated locations for NP_061829.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 3' end compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AJ011375, AL445645, CK906174, HY024188
    Consensus CDS
    CCDS6955.1
    UniProtKB/Swiss-Prot
    Q96E40
    Related
    ENSP00000298546.7, ENST00000350499.6
    Conserved Domains (1) summary
    pfam15120
    Location:1163
    DUF4561; Domain of unknown function (DUF4561)

RNA

  1. NR_133631.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate first exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC012940, DA134573, DA281620

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    132878320..132890314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447397.1XP_024303165.1  sperm acrosome-associated protein 9 isoform X3

    Conserved Domains (1) summary
    pfam15120
    Location:1163
    DUF4561; Domain of unknown function (DUF4561)
  2. XM_024447396.1XP_024303164.1  sperm acrosome-associated protein 9 isoform X1

    Conserved Domains (1) summary
    pfam15120
    Location:1163
    DUF4561; Domain of unknown function (DUF4561)
  3. XM_017014231.1XP_016869720.1  sperm acrosome-associated protein 9 isoform X2

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