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TLK2 tousled like kinase 2 [ Homo sapiens (human) ]

Gene ID: 11011, updated on 7-Jan-2024

Summary

Official Symbol
TLK2provided by HGNC
Official Full Name
tousled like kinase 2provided by HGNC
Primary source
HGNC:HGNC:11842
See related
Ensembl:ENSG00000146872 MIM:608439; AllianceGenome:HGNC:11842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsHPK; MRD57; PKU-ALPHA
Summary
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TLK2 in Genome Data Viewer
Location:
17q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62470914..62615481)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63340853..63485425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60555172..60692842)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60500991-60501521 Neighboring gene methyltransferase 2A, tRNA N3-cytidine Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene mannose receptor C type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene RNA, U6 small nuclear 446, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tousled-like kinase 2 (TLK2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC44450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase tousled-like 2
NP_001271262.1
NP_001271292.1
NP_001317347.1
NP_001362198.1
NP_001362199.1
NP_001362200.1
NP_001362201.1
NP_001362202.1
NP_001398003.1
NP_006843.2
XP_011522517.2
XP_011522518.1
XP_011522520.2
XP_011522522.2
XP_011522523.1
XP_011522524.1
XP_011522525.1
XP_011522528.1
XP_011522529.1
XP_011522533.2
XP_016879533.2
XP_016879537.1
XP_016879538.1
XP_016879539.1
XP_016879540.1
XP_016879542.1
XP_016879543.1
XP_016879544.1
XP_024306320.1
XP_024306321.1
XP_047291130.1
XP_047291131.1
XP_047291132.1
XP_047291133.1
XP_047291134.1
XP_047291135.1
XP_047291136.1
XP_047291137.1
XP_047291138.1
XP_047291139.1
XP_047291141.1
XP_047291142.1
XP_047291143.1
XP_054170754.1
XP_054170755.1
XP_054170756.1
XP_054170757.1
XP_054170758.1
XP_054170759.1
XP_054170760.1
XP_054170761.1
XP_054170762.1
XP_054170763.1
XP_054170764.1
XP_054170765.1
XP_054170766.1
XP_054170767.1
XP_054170768.1
XP_054170769.1
XP_054170770.1
XP_054170771.1
XP_054170772.1
XP_054170773.1
XP_054170774.1
XP_054170775.1
XP_054170776.1
XP_054170777.1
XP_054170778.1
XP_054170779.1
XP_054170780.1
XP_054170781.1
XP_054170782.1
XP_054170783.1
XP_054170784.1
XP_054170785.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284333.3NP_001271262.1  serine/threonine-protein kinase tousled-like 2 isoform C

    See identical proteins and their annotated locations for NP_001271262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) represents the longest transcript and encodes the longest isoform (C).
    Source sequence(s)
    AC080038, AI381985, BC044925, BX647225
    Consensus CDS
    CCDS62283.1
    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000316512.9, ENST00000326270.13
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001284363.1NP_001271292.1  serine/threonine-protein kinase tousled-like 2 isoform B

    See identical proteins and their annotated locations for NP_001271292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant C. The encoded protein (isoform B) is shorter than isoform C.
    Source sequence(s)
    AC008026, AC080038, AK300586, BM668399, BX647225
    Consensus CDS
    CCDS45753.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000508242.1, ENST00000683104.1
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  3. NM_001330418.3NP_001317347.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038, BM668399
    Consensus CDS
    CCDS82182.1
    UniProtKB/TrEMBL
    B4DUC2, J3QLK5
    Related
    ENSP00000508315.1, ENST00000683536.1
    Conserved Domains (2) summary
    COG1196
    Location:57354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:284592
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  4. NM_001375269.1NP_001362198.1  serine/threonine-protein kinase tousled-like 2 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:220517
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:447755
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  5. NM_001375270.1NP_001362199.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  6. NM_001375271.1NP_001362200.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000506744.1, ENST00000682085.1
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  7. NM_001375272.1NP_001362201.1  serine/threonine-protein kinase tousled-like 2 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS45753.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000506988.1, ENST00000682075.1
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  8. NM_001375273.1NP_001362202.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS82182.1
    UniProtKB/TrEMBL
    B4DUC2, J3QLK5
    Related
    ENSP00000507584.1, ENST00000682203.1
    Conserved Domains (2) summary
    COG1196
    Location:57354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:284592
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  9. NM_001411074.1NP_001398003.1  serine/threonine-protein kinase tousled-like 2 isoform F

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
    Consensus CDS
    CCDS92374.1
    UniProtKB/TrEMBL
    A0A804HK10, A0A804HKF1
  10. NM_006852.6NP_006843.2  serine/threonine-protein kinase tousled-like 2 isoform A

    See identical proteins and their annotated locations for NP_006843.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C.
    Source sequence(s)
    AB004884, AC008026, AC080038, AF162667, AI381985, BX647225
    Consensus CDS
    CCDS11633.1
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000275780.7, ENST00000346027.10
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    62470914..62615481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450552.2XP_024306320.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:462770
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:209444
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024450553.2XP_024306321.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_047435179.1XP_047291135.1  serine/threonine-protein kinase tousled-like 2 isoform X12

    UniProtKB/TrEMBL
    B4DUC2
  4. XM_011524221.3XP_011522523.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_047435182.1XP_047291138.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
  6. XM_011524216.3XP_011522518.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    See identical proteins and their annotated locations for XP_011522518.1

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_047435183.1XP_047291139.1  serine/threonine-protein kinase tousled-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A804HKF1
  8. XM_047435185.1XP_047291141.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9, A0A804HKF1
  9. XM_047435180.1XP_047291136.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
  10. XM_017024053.3XP_016879542.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  11. XM_011524222.4XP_011522524.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    See identical proteins and their annotated locations for XP_011522524.1

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_017024054.3XP_016879543.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9, A0A804HKF1
    Related
    ENSP00000507712.1, ENST00000684440.1
  13. XM_017024048.3XP_016879537.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_017024051.3XP_016879540.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000340800.7, ENST00000343388.11
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  15. XM_017024055.3XP_016879544.1  serine/threonine-protein kinase tousled-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A804HK10, A0A804HKF1
    Related
    ENSP00000507724.1, ENST00000684772.1
  16. XM_017024049.3XP_016879538.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_011524223.4XP_011522525.1  serine/threonine-protein kinase tousled-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A804HKF1
    Conserved Domains (2) summary
    smart00220
    Location:410678
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:392700
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  18. XM_047435174.1XP_047291130.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    UniProtKB/TrEMBL
    B4DUC2
  19. XM_047435176.1XP_047291132.1  serine/threonine-protein kinase tousled-like 2 isoform X3

    UniProtKB/TrEMBL
    B4DUC2
  20. XM_011524215.3XP_011522517.2  serine/threonine-protein kinase tousled-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A804HKF1
  21. XM_011524218.3XP_011522520.2  serine/threonine-protein kinase tousled-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A804HKF1
  22. XM_011524220.3XP_011522522.2  serine/threonine-protein kinase tousled-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A804HKF1
  23. XM_047435181.1XP_047291137.1  serine/threonine-protein kinase tousled-like 2 isoform X14

    UniProtKB/TrEMBL
    A0A804HKF1
  24. XM_047435177.1XP_047291133.1  serine/threonine-protein kinase tousled-like 2 isoform X6

    UniProtKB/TrEMBL
    B4DUC2
  25. XM_047435178.1XP_047291134.1  serine/threonine-protein kinase tousled-like 2 isoform X10

    UniProtKB/TrEMBL
    B4DUC2
  26. XM_047435175.1XP_047291131.1  serine/threonine-protein kinase tousled-like 2 isoform X2

    UniProtKB/TrEMBL
    B4DUC2
  27. XM_017024044.2XP_016879533.2  serine/threonine-protein kinase tousled-like 2 isoform X4

    UniProtKB/TrEMBL
    B4DUC2
  28. XM_017024050.2XP_016879539.1  serine/threonine-protein kinase tousled-like 2 isoform X15

    UniProtKB/TrEMBL
    A0A804HKF1
    Related
    ENSP00000507902.1, ENST00000684012.1
  29. XM_011524231.2XP_011522533.2  serine/threonine-protein kinase tousled-like 2 isoform X22

  30. XM_011524226.3XP_011522528.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    See identical proteins and their annotated locations for XP_011522528.1

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  31. XM_011524227.3XP_011522529.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    See identical proteins and their annotated locations for XP_011522529.1

    UniProtKB/TrEMBL
    B4DUC2
    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  32. XM_047435187.1XP_047291143.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    UniProtKB/TrEMBL
    B4DUC2
  33. XM_047435186.1XP_047291142.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    UniProtKB/TrEMBL
    B4DUC2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    63340853..63485425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314785.1XP_054170760.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    UniProtKB/TrEMBL
    B4DUC2
  2. XM_054314788.1XP_054170763.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
  3. XM_054314792.1XP_054170767.1  serine/threonine-protein kinase tousled-like 2 isoform X12

    UniProtKB/TrEMBL
    B4DUC2
  4. XM_054314796.1XP_054170771.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
  5. XM_054314800.1XP_054170775.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
  6. XM_054314786.1XP_054170761.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
  7. XM_054314802.1XP_054170777.1  serine/threonine-protein kinase tousled-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A804HKF1
  8. XM_054314804.1XP_054170779.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9, A0A804HKF1
  9. XM_054314794.1XP_054170769.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
  10. XM_054314799.1XP_054170774.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
  11. XM_054314787.1XP_054170762.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    UniProtKB/Swiss-Prot
    D3DU07, Q86UE8, Q9UKI7, Q9Y4F7
    UniProtKB/TrEMBL
    B4DUC2
  12. XM_054314805.1XP_054170780.1  serine/threonine-protein kinase tousled-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A804HJZ9, A0A804HKF1
  13. XM_054314795.1XP_054170770.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
  14. XM_054314801.1XP_054170776.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    UniProtKB/TrEMBL
    B4DUC2
  15. XM_054314809.1XP_054170784.1  serine/threonine-protein kinase tousled-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A804HK10, A0A804HKF1
  16. XM_054314793.1XP_054170768.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    B4DUC2
  17. XM_054314803.1XP_054170778.1  serine/threonine-protein kinase tousled-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A804HKF1
  18. XM_054314779.1XP_054170754.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    UniProtKB/TrEMBL
    B4DUC2
  19. XM_054314781.1XP_054170756.1  serine/threonine-protein kinase tousled-like 2 isoform X3

    UniProtKB/TrEMBL
    B4DUC2
  20. XM_054314783.1XP_054170758.1  serine/threonine-protein kinase tousled-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A804HKF1
  21. XM_054314789.1XP_054170764.1  serine/threonine-protein kinase tousled-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A804HKF1
  22. XM_054314791.1XP_054170766.1  serine/threonine-protein kinase tousled-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A804HKF1
  23. XM_054314797.1XP_054170772.1  serine/threonine-protein kinase tousled-like 2 isoform X14

    UniProtKB/TrEMBL
    A0A804HKF1
  24. XM_054314784.1XP_054170759.1  serine/threonine-protein kinase tousled-like 2 isoform X6

    UniProtKB/TrEMBL
    B4DUC2
  25. XM_054314790.1XP_054170765.1  serine/threonine-protein kinase tousled-like 2 isoform X10

    UniProtKB/TrEMBL
    B4DUC2
  26. XM_054314780.1XP_054170755.1  serine/threonine-protein kinase tousled-like 2 isoform X2

    UniProtKB/TrEMBL
    B4DUC2
  27. XM_054314782.1XP_054170757.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    UniProtKB/TrEMBL
    B4DUC2
  28. XM_054314798.1XP_054170773.1  serine/threonine-protein kinase tousled-like 2 isoform X15

    UniProtKB/TrEMBL
    A0A804HKF1
  29. XM_054314810.1XP_054170785.1  serine/threonine-protein kinase tousled-like 2 isoform X22

  30. XM_054314806.1XP_054170781.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    UniProtKB/TrEMBL
    B4DUC2
  31. XM_054314807.1XP_054170782.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    UniProtKB/TrEMBL
    B4DUC2
  32. XM_054314808.1XP_054170783.1  serine/threonine-protein kinase tousled-like 2 isoform X20

    UniProtKB/TrEMBL
    B4DUC2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001112707.1: Suppressed sequence

    Description
    NM_001112707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.