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TLK2 tousled like kinase 2 [ Homo sapiens (human) ]

Gene ID: 11011, updated on 9-Feb-2020

Summary

Official Symbol
TLK2provided by HGNC
Official Full Name
tousled like kinase 2provided by HGNC
Primary source
HGNC:HGNC:11842
See related
Ensembl:ENSG00000146872 MIM:608439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsHPK; MRD57; PKU-ALPHA
Summary
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See TLK2 in Genome Data Viewer
Location:
17q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (62470908..62615481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60554447..60692842)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene methyltransferase like 2A Neighboring gene uncharacterized LOC112268200 Neighboring gene uncharacterized LOC112268201 Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene uncharacterized LOC112268202 Neighboring gene uncharacterized LOC107985020 Neighboring gene mannose receptor C type 2 Neighboring gene RNA, U6 small nuclear 446, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tousled-like kinase 2 (TLK2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chromatin assembly or disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromatin assembly or disassembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase tousled-like 2
NP_001271262.1
NP_001271292.1
NP_001317347.1
NP_001362198.1
NP_001362199.1
NP_001362200.1
NP_001362201.1
NP_001362202.1
NP_006843.2
XP_011522517.1
XP_011522518.1
XP_011522519.1
XP_011522520.1
XP_011522522.1
XP_011522523.1
XP_011522524.1
XP_011522525.1
XP_011522526.1
XP_011522527.1
XP_011522528.1
XP_011522529.1
XP_011522530.1
XP_011522531.1
XP_011522533.1
XP_016879533.1
XP_016879537.1
XP_016879538.1
XP_016879539.1
XP_016879540.1
XP_016879542.1
XP_016879543.1
XP_016879544.1
XP_016879545.1
XP_016879546.1
XP_016879549.1
XP_024306320.1
XP_024306321.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284333.2NP_001271262.1  serine/threonine-protein kinase tousled-like 2 isoform C

    See identical proteins and their annotated locations for NP_001271262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) represents the longest transcript and encodes the longest isoform (C).
    Source sequence(s)
    AC080038, AI381985, BC044925, BX647225
    Consensus CDS
    CCDS62283.1
    UniProtKB/Swiss-Prot
    Q86UE8
    Related
    ENSP00000316512.9, ENST00000326270.13
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001284363.1NP_001271292.1  serine/threonine-protein kinase tousled-like 2 isoform B

    See identical proteins and their annotated locations for NP_001271292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant C. The encoded protein (isoform B) is shorter than isoform C.
    Source sequence(s)
    AC008026, AC080038, AK300586, BM668399, BX647225
    Consensus CDS
    CCDS45753.1
    UniProtKB/Swiss-Prot
    Q86UE8
    UniProtKB/TrEMBL
    B4DUC2
    Related
    ENSP00000462036.1, ENST00000581041.5
    Conserved Domains (2) summary
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:174471
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001330418.2NP_001317347.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038, BM668399
    Consensus CDS
    CCDS82182.1
    UniProtKB/TrEMBL
    J3QLK5
    Related
    ENSP00000463595.1, ENST00000582809.5
    Conserved Domains (2) summary
    cd14041
    Location:284592
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    pfam17380
    Location:49282
    DUF5401; Family of unknown function (DUF5401)
  4. NM_001375269.1NP_001362198.1  serine/threonine-protein kinase tousled-like 2 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
  5. NM_001375270.1NP_001362199.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
  6. NM_001375271.1NP_001362200.1  serine/threonine-protein kinase tousled-like 2 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
  7. NM_001375272.1NP_001362201.1  serine/threonine-protein kinase tousled-like 2 isoform F

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
  8. NM_001375273.1NP_001362202.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC008026, AC080038
  9. NM_006852.6NP_006843.2  serine/threonine-protein kinase tousled-like 2 isoform A

    See identical proteins and their annotated locations for NP_006843.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an alternate in-frame exon in the 3' coding region compared to variant C. The encoded protein (isoform A) is shorter than isoform C.
    Source sequence(s)
    AB004884, AC008026, AC080038, AF162667, AI381985, BX647225
    Consensus CDS
    CCDS11633.1
    UniProtKB/Swiss-Prot
    Q86UE8
    Related
    ENSP00000275780.7, ENST00000346027.9
    Conserved Domains (2) summary
    smart00220
    Location:451719
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    62470908..62615481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450552.1XP_024306320.1  serine/threonine-protein kinase tousled-like 2 isoform X3

    Conserved Domains (2) summary
    cd14041
    Location:462770
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:209444
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024450553.1XP_024306321.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_017024053.2XP_016879542.1  serine/threonine-protein kinase tousled-like 2 isoform X10

    UniProtKB/Swiss-Prot
    Q86UE8
    Conserved Domains (2) summary
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:174471
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_011524228.3XP_011522530.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    See identical proteins and their annotated locations for XP_011522530.1

    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  5. XM_011524217.3XP_011522519.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_011522519.1

    UniProtKB/Swiss-Prot
    Q86UE8
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_011524225.3XP_011522527.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    See identical proteins and their annotated locations for XP_011522527.1

    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  7. XM_011524229.2XP_011522531.1  serine/threonine-protein kinase tousled-like 2 isoform X16

    Conserved Domains (2) summary
    smart00220
    Location:324592
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:306614
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  8. XM_011524216.2XP_011522518.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_011522518.1

    UniProtKB/Swiss-Prot
    Q86UE8
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_011524221.2XP_011522523.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_011524222.3XP_011522524.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_011522524.1

    UniProtKB/Swiss-Prot
    Q86UE8
    Conserved Domains (2) summary
    cd14041
    Location:455763
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:202437
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_017024054.2XP_016879543.1  serine/threonine-protein kinase tousled-like 2 isoform X12

  12. XM_017024048.2XP_016879537.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  13. XM_017024051.2XP_016879540.1  serine/threonine-protein kinase tousled-like 2 isoform X10

    UniProtKB/Swiss-Prot
    Q86UE8
    Related
    ENSP00000340800.7, ENST00000343388.11
    Conserved Domains (2) summary
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:174471
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_017024055.2XP_016879544.1  serine/threonine-protein kinase tousled-like 2 isoform X14

  15. XM_011524224.3XP_011522526.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    See identical proteins and their annotated locations for XP_011522526.1

    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  16. XM_017024056.2XP_016879545.1  serine/threonine-protein kinase tousled-like 2 isoform X15

    Conserved Domains (2) summary
    cd14041
    Location:329637
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:102399
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_017024049.2XP_016879538.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    Conserved Domains (2) summary
    cd14041
    Location:423731
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:170405
    SMC_N; RecF/RecN/SMC N terminal domain
  18. XM_011524223.3XP_011522525.1  serine/threonine-protein kinase tousled-like 2 isoform X11

    Conserved Domains (2) summary
    smart00220
    Location:410678
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:392700
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  19. XM_017024060.1XP_016879549.1  serine/threonine-protein kinase tousled-like 2 isoform X19

  20. XM_011524227.2XP_011522529.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    See identical proteins and their annotated locations for XP_011522529.1

    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  21. XM_017024057.1XP_016879546.1  serine/threonine-protein kinase tousled-like 2 isoform X15

    Conserved Domains (2) summary
    cd14041
    Location:329637
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
    cl25732
    Location:102399
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_011524226.2XP_011522528.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    See identical proteins and their annotated locations for XP_011522528.1

    Conserved Domains (2) summary
    smart00220
    Location:369637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:351659
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  23. XM_017024050.1XP_016879539.1  serine/threonine-protein kinase tousled-like 2 isoform X9

  24. XM_017024044.1XP_016879533.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q86UE8
    Conserved Domains (2) summary
    smart00220
    Location:451719
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  25. XM_011524215.2XP_011522517.1  serine/threonine-protein kinase tousled-like 2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:442710
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:424732
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  26. XM_011524218.2XP_011522520.1  serine/threonine-protein kinase tousled-like 2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:420688
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:402710
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  27. XM_011524220.2XP_011522522.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:410678
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14041
    Location:392700
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  28. XM_011524231.1XP_011522533.1  serine/threonine-protein kinase tousled-like 2 isoform X18

    Conserved Domains (1) summary
    cl21453
    Location:455508
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001112707.1: Suppressed sequence

    Description
    NM_001112707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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