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Tlk2 tousled-like kinase 2 (Arabidopsis) [ Mus musculus (house mouse) ]

Gene ID: 24086, updated on 13-Oct-2022

Summary

Official Symbol
Tlk2provided by MGI
Official Full Name
tousled-like kinase 2 (Arabidopsis)provided by MGI
Primary source
MGI:MGI:1346023
See related
Ensembl:ENSMUSG00000020694 AllianceGenome:MGI:1346023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tlk; PKUalpha; PKU-alpha; 4933403M19Rik
Summary
Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to act upstream of or within several processes, including chromatin organization; phosphorylation; and spermatogenesis. Located in intermediate filament; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 7.8), CNS E11.5 (RPKM 5.0) and 27 other tissues See more
Orthologs
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Genomic context

See Tlk2 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105066869..105174785)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105167895..105283959)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 2 Neighboring gene RIKEN cDNA 1700052K11 gene Neighboring gene predicted gene 11620 Neighboring gene predicted gene, 53649 Neighboring gene mannose receptor, C type 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase tousled-like 2
Names
protein kinase U-alpha
NP_001106176.1
NP_001281258.1
NP_001281259.1
NP_001281260.1
NP_001281263.1
NP_001348925.1
XP_006533375.1
XP_006533376.1
XP_006533379.2
XP_006533383.1
XP_011247316.1
XP_030101858.1
XP_030101859.1
XP_030101861.1
XP_030101862.1
XP_036012594.1
XP_036012595.1
XP_036012596.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112705.2NP_001106176.1  serine/threonine-protein kinase tousled-like 2 isoform A

    See identical proteins and their annotated locations for NP_001106176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AL645471
    Consensus CDS
    CCDS48954.1
    UniProtKB/TrEMBL
    A0A8C6N324, B1ASU9
    Related
    ENSMUSP00000102554.3, ENSMUST00000106941.9
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  2. NM_001294329.1NP_001281258.1  serine/threonine-protein kinase tousled-like 2 isoform C

    See identical proteins and their annotated locations for NP_001281258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A; the 5'-most initiation codon, as used in variant A, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate AUG to encode an isoform (C) that has a distinct N-terminus, and is shorter, compared to isoform A.
    Source sequence(s)
    AL645471
    Conserved Domains (2) summary
    COG1196
    Location:102399
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:329637
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  3. NM_001294330.1NP_001281259.1  serine/threonine-protein kinase tousled-like 2 isoform D

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) lacks two alternate in-frame exons in the 5' coding region and its 3' terminal exon extends past a splice site that is used in variant A. This results in a novel 3' coding region and 3' UTR compared to variant A. The encoded isoform (D) is shorter, and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AL645471, BC066198
    Consensus CDS
    CCDS79063.1
    UniProtKB/TrEMBL
    B7ZC85, Q6NZC4
    Related
    ENSMUSP00000118520.2, ENSMUST00000145048.8
    Conserved Domains (2) summary
    smart00220
    Location:387592
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:369593
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001294331.1NP_001281260.1  serine/threonine-protein kinase tousled-like 2 isoform B

    See identical proteins and their annotated locations for NP_001281260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant A. The encoded isoform (B) is shorter than isoform A.
    Source sequence(s)
    AL645471
    Consensus CDS
    CCDS36356.2
    UniProtKB/Swiss-Prot
    O55047, Q9D5Y5
    UniProtKB/TrEMBL
    A0A8C6I4I3
    Related
    ENSMUSP00000102552.3, ENSMUST00000106939.9
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  5. NM_001294334.1NP_001281263.1  serine/threonine-protein kinase tousled-like 2 isoform E

    Status: VALIDATED

    Description
    Transcript Variant: This variant (E) contains a 3' terminal exon that extends past a splice site that is used in variant A. This results in a novel 3' coding region and 3' UTR compared to variant A. The encoded isoform (E) is shorter, and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK014829, AL645471, BC066198
    Consensus CDS
    CCDS79062.1
    UniProtKB/Swiss-Prot
    O55047
    UniProtKB/TrEMBL
    Q6NZC4
    Related
    ENSMUSP00000090198.4, ENSMUST00000092537.10
    Conserved Domains (2) summary
    smart00220
    Location:451656
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:433657
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001361996.1NP_001348925.1  serine/threonine-protein kinase tousled-like 2 isoform F

    Status: VALIDATED

    Source sequence(s)
    AL645471, AW490750
    Conserved Domains (1) summary
    cd14041
    Location:369677
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105066869..105174785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533312.5XP_006533375.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006533375.1

    UniProtKB/TrEMBL
    A0A8C6N324, B1ASU9
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  2. XM_036156701.1XP_036012594.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    UniProtKB/Swiss-Prot
    Q9D5Y5
    UniProtKB/TrEMBL
    A0A8C6I4I3
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  3. XM_036156702.1XP_036012595.1  serine/threonine-protein kinase tousled-like 2 isoform X6

    Conserved Domains (1) summary
    cd14041
    Location:364672
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  4. XM_030246002.2XP_030101862.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    Conserved Domains (1) summary
    cd14041
    Location:338646
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  5. XM_030246001.2XP_030101861.1  serine/threonine-protein kinase tousled-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C6I4M0
    Conserved Domains (1) summary
    cd14041
    Location:370678
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  6. XM_011249014.4XP_011247316.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_011247316.1

    UniProtKB/Swiss-Prot
    O55047, Q9D5Y5
    UniProtKB/TrEMBL
    A0A8C6I4I3
    Related
    ENSMUSP00000015107.7, ENSMUST00000015107.13
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  7. XM_030245999.2XP_030101859.1  serine/threonine-protein kinase tousled-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C6N2T9
    Conserved Domains (2) summary
    COG1196
    Location:182471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  8. XM_030245998.2XP_030101858.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6N324, B1ASU9
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  9. XM_006533313.5XP_006533376.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006533376.1

    UniProtKB/TrEMBL
    A0A8C6N324, B1ASU9
    Conserved Domains (2) summary
    COG1196
    Location:206503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  10. XM_036156703.1XP_036012596.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    UniProtKB/Swiss-Prot
    Q9D5Y5
    UniProtKB/TrEMBL
    A0A8C6I4I3
    Conserved Domains (2) summary
    COG1196
    Location:174471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  11. XM_006533320.5XP_006533383.1  serine/threonine-protein kinase tousled-like 2 isoform X8

    See identical proteins and their annotated locations for XP_006533383.1

    Conserved Domains (2) summary
    COG1196
    Location:102399
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:329637
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
  12. XM_006533316.5XP_006533379.2  serine/threonine-protein kinase tousled-like 2 isoform X2

    Conserved Domains (1) summary
    cd14041
    Location:396704
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011903.3: Suppressed sequence

    Description
    NM_011903.3: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.