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ZNF273 zinc finger protein 273 [ Homo sapiens (human) ]

Gene ID: 10793, updated on 25-Jan-2022

Summary

Official Symbol
ZNF273provided by HGNC
Official Full Name
zinc finger protein 273provided by HGNC
Primary source
HGNC:HGNC:13067
See related
Ensembl:ENSG00000198039 MIM:604756; AllianceGenome:HGNC:13067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF9
Summary
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 16.5), bone marrow (RPKM 2.0) and 6 other tissues See more
Orthologs
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Genomic context

See ZNF273 in Genome Data Viewer
Location:
7q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (64877603..64932239)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64337981..64391359)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 138 Neighboring gene selenophosphate synthetase 1 pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 4 Neighboring gene uncharacterized LOC441239 Neighboring gene vomeronasal 1 receptor 42 pseudogene Neighboring gene metadherin pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 273
Names
zinc finger protein 9
zinc finger protein HZF9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385643.1NP_001372572.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_001385644.1NP_001372573.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. NM_001385645.1NP_001372574.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. NM_001385646.1NP_001372575.1  zinc finger protein 273 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (2) summary
    COG5048
    Location:94440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:251271
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001385647.1NP_001372576.1  zinc finger protein 273 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (1) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
  6. NM_001385649.1NP_001372578.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  7. NM_001385650.1NP_001372579.1  zinc finger protein 273 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (1) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
  8. NM_001385652.1NP_001372581.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  9. NM_001388021.1NP_001374950.1  zinc finger protein 273 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  10. NM_021148.3NP_066971.2  zinc finger protein 273 isoform 1

    See identical proteins and their annotated locations for NP_066971.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092161
    Consensus CDS
    CCDS5528.2
    UniProtKB/Swiss-Prot
    Q14593
    Related
    ENSP00000418719.1, ENST00000476120.2
    Conserved Domains (5) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
    COG5048
    Location:191537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:348368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:501525
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_169738.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  2. NR_169741.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  3. NR_169742.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  4. NR_169743.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  5. NR_169744.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  6. NR_169745.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  7. NR_169746.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349, AC092161
  8. NR_169747.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161
  9. NR_169748.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161
  10. NR_170871.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092161
    Related
    ENST00000489672.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    64877603..64932239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446635.1XP_024302403.1  zinc finger protein 273 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. XM_024446636.1XP_024302404.1  zinc finger protein 273 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. XM_024446640.1XP_024302408.1  zinc finger protein 273 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:126472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033548.1: Suppressed sequence

    Description
    NM_033548.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NR_003099.1: Suppressed sequence

    Description
    NR_003099.1: This RefSeq was removed because it is now thought that this transcript is protein coding.
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