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RASGRP2 RAS guanyl releasing protein 2 [ Rousettus aegyptiacus (Egyptian rousette) ]

Gene ID: 107517268, updated on 30-Mar-2024

Summary

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Gene symbol
RASGRP2
Gene description
RAS guanyl releasing protein 2
Locus tag
HJG63_016424
Gene type
protein coding
RefSeq status
MODEL
Organism
Rousettus aegyptiacus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Rousettinae; Rousettus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
101 current mRouAeg1.p (GCF_014176215.1) Unplaced Scaffold NW_023416308.1 (115956959..115971379, complement)
100 previous assembly Raegyp2.0 (GCF_001466805.2) Unplaced Scaffold NW_015492938.1 (205762..220103)

NW_023416308.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 11 Neighboring gene neurexin 2 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene splicing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAS guanyl-releasing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rousettus aegyptiacus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRouAeg1.p

Genomic

  1. NW_023416308.1 Reference mRouAeg1.p

    Range
    115956959..115971379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016157840.2 → XP_016013326.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A7J8H4X0
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_016157833.2 → XP_016013319.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A7J8H4X0
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_016157824.2 → XP_016013310.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A7J8H4X0
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_016157846.2 → XP_016013332.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A7J8H4X0
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_016157855.2 → XP_016013341.1  RAS guanyl-releasing protein 2 isoform X3

    Conserved Domains (5) summary
    smart00147
    Location:113 → 350
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:1 → 84
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:462 → 511
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:393 → 444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:394 → 447
    EF-hand_7; EF-hand domain pair

  6. XM_016157861.2 → XP_016013347.1  RAS guanyl-releasing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A7J8H550
    Conserved Domains (3) summary
    smart00147
    Location:12 → 249
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:292 → 343
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:358 → 413
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_036220316.1 → XP_036076209.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:496 → 530
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
Nucleotide Protein
Heading Accession and Version

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