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Rasgrp2 RAS, guanyl releasing protein 2 [ Mus musculus (house mouse) ]

Gene ID: 19395, updated on 9-May-2024

Summary

Official Symbol
Rasgrp2provided by MGI
Official Full Name
RAS, guanyl releasing protein 2provided by MGI
Primary source
MGI:MGI:1333849
See related
Ensembl:ENSMUSG00000032946 AllianceGenome:MGI:1333849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDC25L; Caldaggef1; CalDAG-GEFI
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to calcium ion and positive regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Is expressed in brain. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 41.2), thymus adult (RPKM 27.3) and 24 other tissues See more
Orthologs
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Genomic context

Location:
19 A; 19 4.58 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6449038..6465243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6398957..6415216)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene splicing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4263 Neighboring gene muscle glycogen phosphorylase Neighboring gene STARR-seq mESC enhancer starr_45434 Neighboring gene STARR-positive B cell enhancer ABC_E8733 Neighboring gene predicted gene 14965 Neighboring gene neurexin II Neighboring gene STARR-seq mESC enhancer starr_45436 Neighboring gene STARR-positive B cell enhancer ABC_E5683 Neighboring gene predicted gene, 52381 Neighboring gene solute carrier family 22 (organic anion/cation transporter), member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RAS guanyl-releasing protein 2
Names
F25B3.3 kinase like protein
RAP 1A protein-specific guanine nucleotide exchange factor 1
calcium and DAG-regulated guanine nucleotide exchange factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365062.1NP_001351991.1  RAS guanyl-releasing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS89325.1
    UniProtKB/TrEMBL
    D6RDD3
    Related
    ENSMUSP00000123036.2, ENSMUST00000139522.8
    Conserved Domains (1) summary
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. NM_001365063.1NP_001351992.1  RAS guanyl-releasing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC051474, BE457673
    Consensus CDS
    CCDS89325.1
    UniProtKB/TrEMBL
    D6RDD3
    Related
    ENSMUSP00000109099.2, ENSMUST00000113471.3
    Conserved Domains (1) summary
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  3. NM_001411231.1NP_001398160.1  RAS guanyl-releasing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167245
    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
  4. NM_001411232.1NP_001398161.1  RAS guanyl-releasing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167245
    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
  5. NM_011242.4NP_035372.2  RAS guanyl-releasing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035372.2

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS37898.1
    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Related
    ENSMUSP00000129873.2, ENSMUST00000167240.8
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. NR_157554.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BE457673, BE655519, CJ058933

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6449038..6465243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250784.1XP_030106644.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:113350
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:184
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:462511
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:393444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_006531687.2XP_006531750.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531750.1

    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_006531691.3XP_006531754.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531754.1

    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Related
    ENSMUSP00000109104.2, ENSMUST00000113476.8
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_030250792.1XP_030106652.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_030250788.2XP_030106648.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  6. XM_006531686.5XP_006531749.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531749.1

    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  7. XM_030250783.2XP_030106643.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:113350
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:184
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:462511
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:393444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  8. XM_006531692.5XP_006531755.1  RAS guanyl-releasing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00147
    Location:78315
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:427476
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:358409
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02520
    Location:249
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
  9. XM_030250790.2XP_030106650.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  10. XM_030250787.1XP_030106647.1  RAS guanyl-releasing protein 2 isoform X4

    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl25354
    Location:401451
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    pfam00036
    Location:431452
    EF-hand_1; EF hand
  11. XM_036161468.1XP_036017361.1  RAS guanyl-releasing protein 2 isoform X6

    UniProtKB/TrEMBL
    D6RDD3
    Conserved Domains (1) summary
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  12. XM_006531688.3XP_006531751.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531751.1

    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Related
    ENSMUSP00000041135.9, ENSMUST00000035716.15
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  13. XM_030250786.1XP_030106646.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:113350
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:184
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:462511
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:393444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  14. XM_011248615.2XP_011246917.1  RAS guanyl-releasing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011246917.1

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  15. XM_030250789.1XP_030106649.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  16. XM_030250785.1XP_030106645.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:113350
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:184
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:462511
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:393444
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  17. XM_006531690.3XP_006531753.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531753.1

    UniProtKB/Swiss-Prot
    O09004, Q80WC0, Q8BSC8, Q9QUG9
    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00029
    Location:499548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:430481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  18. XM_030250791.1XP_030106651.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  19. XM_036161467.1XP_036017360.1  RAS guanyl-releasing protein 2 isoform X6

    UniProtKB/TrEMBL
    D6RDD3
    Conserved Domains (1) summary
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  20. XM_011248613.4XP_011246915.1  RAS guanyl-releasing protein 2 isoform X4

    Conserved Domains (4) summary
    smart00147
    Location:150387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl25354
    Location:401451
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    pfam00036
    Location:431452
    EF-hand_1; EF hand
  21. XM_017318082.1XP_017173571.1  RAS guanyl-releasing protein 2 isoform X5

    Conserved Domains (3) summary
    smart00147
    Location:5242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:354403
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:285336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. XR_003952759.2 RNA Sequence